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GCH1 GTP cyclohydrolase 1 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 695675, updated on 12-Dec-2025
Official Symbol
GCH1provided by VGNC
Official Full Name
GTP cyclohydrolase 1provided by VGNC
Primary source
VGNC:VGNC:72900
See related
Ensembl:ENSMMUG00000004084
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
all
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Try the new Transcripts and proteins table
See GCH1 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2025_08 current T2T-MMU8v2.0 (GCF_049350105.2) 7 NC_133412.1 (127975565..128028911, complement)
103 previous assembly Mmul_10 (GCF_003339765.1) 7 NC_041760.1 (116954239..117007670, complement)

Chromosome 7 - NC_133412.1Genomic Context describing neighboring genes Neighboring gene cell growth regulator with ring finger domain 1 Neighboring gene sterile alpha motif domain containing 4A Neighboring gene U6atac minor spliceosomal RNA Neighboring gene farnesyl pyrophosphate synthase pseudogene Neighboring gene WD repeat and HMG-box DNA binding protein 1 Neighboring gene large ribosomal subunit protein eL31 pseudogene Neighboring gene suppressor of cytokine signaling 4

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GTP cyclohydrolase I activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in tetrahydrobiopterin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tetrahydrofolate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
GTP cyclohydrolase 1
Names
GTP cyclohydrolase 1 (dopa-responsive dystonia)
XP_001087365.1
XP_014999211.1
XP_077797165.1
XP_077797166.1

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_049350105.2-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference T2T-MMU8v2.0

Genomic

  1. NC_133412.1 Reference T2T-MMU8v2.0

    Range
    127975565..128028911 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015143725.3 → XP_014999211.1  GTP cyclohydrolase 1 isoform X1

    UniProtKB/TrEMBL
    F6ZD19
    Conserved Domains (1) summary
    cd00642
    Location:66 → 250
    GTP_cyclohydro1; GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In ...

  2. XM_001087365.5 → XP_001087365.1  GTP cyclohydrolase 1 isoform X1

    See identical proteins and their annotated locations for XP_001087365.1

    UniProtKB/TrEMBL
    F6ZD19
    Related
    ENSMMUP00000005462.4
    Conserved Domains (1) summary
    cd00642
    Location:66 → 250
    GTP_cyclohydro1; GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In ...

  3. XM_077941039.1 → XP_077797165.1  GTP cyclohydrolase 1 isoform X2

  4. XM_077941040.1 → XP_077797166.1  GTP cyclohydrolase 1 isoform X3

Nucleotide Protein
Heading Accession and Version

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Molecular Biology Databases
Research Materials