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Cdk13 cyclin-dependent kinase 13 [ Mus musculus (house mouse) ]

Gene ID: 69562, updated on 12-Aug-2019

Summary

Official Symbol
Cdk13provided by MGI
Official Full Name
cyclin-dependent kinase 13provided by MGI
Primary source
MGI:MGI:1916812
See related
Ensembl:ENSMUSG00000041297
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cdc2l5; 2310015O17Rik
Expression
Ubiquitous expression in ovary adult (RPKM 9.0), thymus adult (RPKM 8.0) and 28 other tissues See more
Orthologs

Genomic context

See Cdk13 in Genome Data Viewer
Location:
13; 13 A2
Exon count:
17
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (17711676..17805212, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (17807796..17896931, complement)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene succinyl-CoA glutarate-CoA transferase Neighboring gene predicted gene, 40826 Neighboring gene M-phase specific PLK1 intereacting protein Neighboring gene U6 spliceosomal RNA Neighboring gene microRNA 466i Neighboring gene predicted gene, 18859

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II CTD heptapeptide repeat kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II CTD heptapeptide repeat kinase activity ISO
Inferred from Sequence Orthology
more info
 
cyclin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cyclin binding IPI
Inferred from Physical Interaction
more info
PubMed 
cyclin binding ISO
Inferred from Sequence Orthology
more info
 
cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription regulatory region DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
RNA splicing IEA
Inferred from Electronic Annotation
more info
 
alternative mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
negative regulation of stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
phosphorylation of RNA polymerase II C-terminal domain IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphorylation of RNA polymerase II C-terminal domain ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription elongation from RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription elongation from RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
chromosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cyclin K-CDK13 complex ISO
Inferred from Sequence Orthology
more info
 
cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cyclin/CDK positive transcription elongation factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nuclear chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear cyclin-dependent protein kinase holoenzyme complex IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cyclin-dependent kinase 13
Names
CDC2-related protein kinase 5
cell division cycle 2-like 5 (cholinesterase-related cell division controller)
cell division cycle 2-like protein kinase 5
cell division protein kinase 13
NP_001074527.1
NP_081394.1
XP_006516829.1
XP_006516830.1
XP_011242646.1
XP_017171082.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081058.2NP_001074527.1  cyclin-dependent kinase 13 isoform 1

    See identical proteins and their annotated locations for NP_001074527.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC154219, AC154828
    Consensus CDS
    CCDS36604.1
    UniProtKB/Swiss-Prot
    Q69ZA1
    Related
    ENSMUSP00000036013.7, ENSMUST00000042365.8
    Conserved Domains (2) summary
    smart00220
    Location:705994
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07864
    Location:697998
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  2. NM_027118.1NP_081394.1  cyclin-dependent kinase 13 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
    Source sequence(s)
    AC154219, AC154828
    UniProtKB/Swiss-Prot
    Q69ZA1
    Related
    ENSMUSP00000152820.1, ENSMUST00000223490.1
    Conserved Domains (2) summary
    smart00220
    Location:705994
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07864
    Location:697998
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000079.6 Reference GRCm38.p6 C57BL/6J

    Range
    17711676..17805212 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516767.4XP_006516830.1  cyclin-dependent kinase 13 isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:705994
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07864
    Location:697998
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  2. XM_006516766.4XP_006516829.1  cyclin-dependent kinase 13 isoform X1

    Conserved Domains (2) summary
    smart00220
    Location:705994
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07864
    Location:697998
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  3. XM_011244344.3XP_011242646.1  cyclin-dependent kinase 13 isoform X4

    Related
    ENSMUSP00000152539.1, ENSMUST00000222800.1
    Conserved Domains (2) summary
    smart00220
    Location:91380
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07864
    Location:83384
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
  4. XM_017315593.2XP_017171082.1  cyclin-dependent kinase 13 isoform X3

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