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TRA T cell receptor alpha locus [ Homo sapiens (human) ]

Gene ID: 6955, updated on 5-Jan-2022

Summary

Official Symbol
TRAprovided by HGNC
Official Full Name
T cell receptor alpha locusprovided by HGNC
Primary source
HGNC:HGNC:12027
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IMD7; TCRA; TRA@
Summary
Enables signaling receptor activity. Involved in T cell mediated cytotoxicity directed against tumor cell target and detection of tumor cell. Part of alpha-beta T cell receptor complex. [provided by Alliance of Genome Resources, Nov 2021]
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Genomic context

See TRA in Genome Data Viewer
Location:
14q11.2
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (21621904..22552132)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (22090057..23021075)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 10 subfamily G member 1 pseudogene Neighboring gene ubiquitin conjugating enzyme E2 N pseudogene 1 Neighboring gene ADP ribosylation factor like GTPase 6 interacting protein 1 pseudogene 1 Neighboring gene T cell receptor alpha variable 1-1 Neighboring gene VISTA enhancer hs1705 Neighboring gene uncharacterized LOC107984650 Neighboring gene T cell receptor alpha variable 1-2 Neighboring gene olfactory receptor family 10 subfamily G member 2 Neighboring gene olfactory receptor family 4 subfamily E member 2 Neighboring gene olfactory receptor family 4 subfamily E member 1 Neighboring gene T cell receptor alpha variable 2 Neighboring gene T cell receptor alpha variable 3 Neighboring gene T cell receptor alpha variable 4 Neighboring gene ribosomal protein L4 pseudogene 1 Neighboring gene T cell receptor alpha variable 5 Neighboring gene T cell receptor alpha variable 6 Neighboring gene T cell receptor alpha variable 8-1 Neighboring gene T cell receptor alpha variable 7 Neighboring gene T cell receptor alpha variable 9-1 Neighboring gene T cell receptor alpha variable 12-1 Neighboring gene T cell receptor alpha variable 10 Neighboring gene T cell receptor alpha variable 11 (pseudogene) Neighboring gene T cell receptor alpha variable 8-2 Neighboring gene T cell receptor alpha variable 8-3 Neighboring gene T cell receptor alpha variable 13-1 Neighboring gene T cell receptor alpha variable 12-2 Neighboring gene T cell receptor alpha variable 8-4 Neighboring gene T cell receptor alpha variable 14/delta variable 4 Neighboring gene T cell receptor alpha variable 8-5 (pseudogene) Neighboring gene T cell receptor alpha variable 13-2 Neighboring gene T cell receptor alpha variable 9-2 Neighboring gene spalt like transcription factor 4 pseudogene Neighboring gene T cell receptor alpha variable 12-3 Neighboring gene T cell receptor alpha variable 15 (pseudogene) Neighboring gene T cell receptor alpha variable 8-6 Neighboring gene T cell receptor alpha variable 16 Neighboring gene T cell receptor alpha variable 17 Neighboring gene T cell receptor alpha variable 18 Neighboring gene T cell receptor alpha variable 19 Neighboring gene Sharpr-MPRA regulatory region 3554 Neighboring gene T cell receptor alpha variable 20 Neighboring gene T cell receptor alpha variable 23/delta variable 6 Neighboring gene T cell receptor alpha variable 21 Neighboring gene T cell receptor alpha variable 22 Neighboring gene T cell receptor alpha variable 26-1 Neighboring gene T cell receptor alpha variable 24 Neighboring gene T cell receptor delta variable 1 Neighboring gene T cell receptor alpha variable 25 Neighboring gene T cell receptor alpha variable 8-7 (pseudogene) Neighboring gene T cell receptor alpha variable 29/delta variable 5 Neighboring gene T cell receptor alpha variable 27 Neighboring gene T cell receptor alpha variable 28 (pseudogene) Neighboring gene T cell receptor alpha variable 30 Neighboring gene T cell receptor alpha variable 26-2 Neighboring gene T cell receptor alpha variable 31 (pseudogene) Neighboring gene T cell receptor alpha variable 36/delta variable 7 Neighboring gene T cell receptor alpha variable 32 (pseudogene) Neighboring gene T cell receptor alpha variable 33 (pseudogene) Neighboring gene T cell receptor alpha variable 34 Neighboring gene uncharacterized LOC107984649 Neighboring gene T cell receptor alpha variable 38-2/delta variable 8 Neighboring gene T cell receptor alpha variable 35 Neighboring gene T cell receptor alpha variable 38-1 Neighboring gene translin associated factor X pseudogene Neighboring gene T cell receptor alpha variable 37 (pseudogene) Neighboring gene uncharacterized LOC105370401 Neighboring gene T cell receptor alpha variable 39 Neighboring gene T cell receptor alpha variable 40 Neighboring gene T cell receptor alpha variable 41 Neighboring gene uncharacterized LOC112267867 Neighboring gene Sharpr-MPRA regulatory region 15263 Neighboring gene T cell receptor delta variable 2 Neighboring gene T cell receptor delta diversity 1 Neighboring gene T cell receptor delta diversity 2 Neighboring gene uncharacterized LOC105370399 Neighboring gene T cell receptor delta locus Neighboring gene T cell receptor delta diversity 3 Neighboring gene T cell receptor delta joining 1 Neighboring gene T cell receptor delta joining 4 Neighboring gene T cell receptor delta joining 2 Neighboring gene T cell receptor delta joining 3 Neighboring gene T cell receptor alpha joining 61 (non-functional) Neighboring gene T cell receptor alpha joining 60 (pseudogene) Neighboring gene T cell receptor alpha joining 59 (non-functional) Neighboring gene T cell receptor alpha joining 58 (non-functional) Neighboring gene T cell receptor alpha joining 57 Neighboring gene T cell receptor alpha joining 56 Neighboring gene T cell receptor delta variable 3 Neighboring gene T cell receptor alpha joining 53 Neighboring gene T cell receptor alpha joining 55 (pseudogene) Neighboring gene T cell receptor alpha joining 54 Neighboring gene T cell receptor alpha joining 52 Neighboring gene T cell receptor alpha joining 51 (pseudogene) Neighboring gene T cell receptor alpha joining 50 Neighboring gene T cell receptor delta constant Neighboring gene T cell receptor alpha joining 48 Neighboring gene T cell receptor alpha joining 49 Neighboring gene T cell receptor alpha joining 47 Neighboring gene T cell receptor alpha joining 45 Neighboring gene T cell receptor alpha joining 46 Neighboring gene T cell receptor alpha joining 44 Neighboring gene T cell receptor alpha joining 42 Neighboring gene T cell receptor alpha joining 43 Neighboring gene T cell receptor alpha joining 41 Neighboring gene long intergenic non-protein coding RNA 2332 Neighboring gene T cell receptor alpha joining 40 Neighboring gene T cell receptor alpha joining 38 Neighboring gene T cell receptor alpha joining 39 Neighboring gene T cell receptor alpha joining 37 Neighboring gene T cell receptor alpha joining 36 Neighboring gene T cell receptor alpha joining 34 Neighboring gene T cell receptor alpha joining 35 (non-functional) Neighboring gene T cell receptor alpha joining 33 Neighboring gene T cell receptor alpha joining 32 Neighboring gene T cell receptor alpha joining 30 Neighboring gene T cell receptor alpha joining 31 Neighboring gene T cell receptor alpha joining 29 Neighboring gene T cell receptor alpha joining 28 Neighboring gene T cell receptor alpha joining 26 Neighboring gene T cell receptor alpha joining 27 Neighboring gene T cell receptor alpha joining 25 (non-functional) Neighboring gene T cell receptor alpha joining 24 Neighboring gene T cell receptor alpha joining 23 Neighboring gene T cell receptor alpha joining 21 Neighboring gene T cell receptor alpha joining 22 Neighboring gene T cell receptor alpha joining 18 Neighboring gene T cell receptor alpha joining 20 Neighboring gene T cell receptor alpha joining 19 (non-functional) Neighboring gene T cell receptor alpha joining 16 Neighboring gene T cell receptor alpha joining 17 Neighboring gene T cell receptor alpha joining 15 Neighboring gene T cell receptor alpha joining 12 Neighboring gene T cell receptor alpha joining 13 Neighboring gene T cell receptor alpha joining 14 Neighboring gene T cell receptor alpha joining 11 Neighboring gene T cell receptor alpha joining 10 Neighboring gene T cell receptor alpha joining 9 Neighboring gene T cell receptor alpha joining 8 Neighboring gene T cell receptor alpha joining 7 Neighboring gene T cell receptor alpha joining 6 Neighboring gene T cell receptor alpha joining 5 Neighboring gene T cell receptor alpha joining 4 Neighboring gene T cell receptor alpha joining 3 Neighboring gene T cell receptor alpha joining 2 (non-functional) Neighboring gene T cell receptor alpha joining 1 (non-functional) Neighboring gene T cell receptor alpha constant

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study of recipient genotype and medium-term kidney allograft function.
GeneReviews: Not available
Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic.
GeneReviews: Not available
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
GeneReviews: Not available
Genome-wide association study and meta-analysis of intraocular pressure.
GeneReviews: Not available
Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy.
GeneReviews: Not available
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
GeneReviews: Not available
Narcolepsy is strongly associated with the T-cell receptor alpha locus.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Other Names

  • T-cell antigen receptor, alpha polypeptide
  • T-cell receptor, alpha (V,D,J,C)
  • TCRA, TRA@

Clone Names

  • FLJ22602, MGC22624, MGC23964, MGC71411, MGC117436

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of alpha-beta T cell receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Names
T cell receptor alpha locus
T-cell antigen receptor, alpha polypeptide
T-cell receptor, alpha (V,D,J,C)
TCRA, TRA@

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_001332.3 

    Range
    1..930229
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    21621904..22552132
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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