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Antxr1 anthrax toxin receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 69538, updated on 31-Jan-2019

Summary

Official Symbol
Antxr1provided by MGI
Official Full Name
anthrax toxin receptor 1provided by MGI
Primary source
MGI:MGI:1916788
See related
Ensembl:ENSMUSG00000033420
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tem8; Antrx1; 2310008J16Rik; 2810405N18Rik
Expression
Broad expression in limb E14.5 (RPKM 23.9), bladder adult (RPKM 13.0) and 20 other tissues See more
Orthologs

Genomic context

See Antxr1 in Genome Data Viewer
Location:
6; 6 D1
Exon count:
19
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (87133853..87335809, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (87083847..87285769, complement)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene DNA segment, Chr 6, ERATO Doi 527, expressed Neighboring gene predicted gene, 40382 Neighboring gene predicted gene, 38851 Neighboring gene predicted gene, 34170 Neighboring gene predicted gene, 34090 Neighboring gene gastrokine 1 Neighboring gene gastrokine 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

  • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
  • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
    NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
actin filament binding ISO
Inferred from Sequence Orthology
more info
 
collagen binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
 
blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of extracellular matrix assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of metallopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
reproductive process IMP
Inferred from Mutant Phenotype
more info
PubMed 
substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
toxin transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cell projection IEA
Inferred from Electronic Annotation
more info
 
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
PubMed 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
filopodium membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lamellipodium membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
anthrax toxin receptor 1
Names
tumor endothelial marker 8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_054041.2NP_473382.1  anthrax toxin receptor 1 precursor

    See identical proteins and their annotated locations for NP_473382.1

    Status: VALIDATED

    Source sequence(s)
    BB649806, BC094544
    Consensus CDS
    CCDS20318.1
    UniProtKB/Swiss-Prot
    Q9CZ52
    Related
    ENSMUSP00000045634.9, ENSMUST00000042025.11
    Conserved Domains (3) summary
    cd01474
    Location:37221
    vWA_ATR; ATR (Anthrax Toxin Receptor): Anthrax toxin is a key virulence factor for Bacillus anthracis, the causative agent of anthrax. ATR is the cellular receptor for the anthrax protective antigen and facilitates entry of the toxin into cells. The VWA domain in ...
    pfam05586
    Location:394486
    Ant_C; Anthrax receptor C-terminus region
    pfam05587
    Location:223317
    Anth_Ig; Anthrax receptor extracellular domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

    Range
    87133853..87335809 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506564.2XP_006506627.1  anthrax toxin receptor 1 isoform X1

    Related
    ENSMUSP00000145105.1, ENSMUST00000204805.2
    Conserved Domains (3) summary
    cd01474
    Location:51235
    vWA_ATR; ATR (Anthrax Toxin Receptor): Anthrax toxin is a key virulence factor for Bacillus anthracis, the causative agent of anthrax. ATR is the cellular receptor for the anthrax protective antigen and facilitates entry of the toxin into cells. The VWA domain in ...
    pfam05586
    Location:408494
    Ant_C; Anthrax receptor C-terminus region
    pfam05587
    Location:237331
    Anth_Ig; Anthrax receptor extracellular domain
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