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Nup35 nucleoporin 35 [ Mus musculus (house mouse) ]

Gene ID: 69482, updated on 8-Dec-2022

Summary

Official Symbol
Nup35provided by MGI
Official Full Name
nucleoporin 35provided by MGI
Primary source
MGI:MGI:1916732
See related
Ensembl:ENSMUSG00000026999 AllianceGenome:MGI:1916732
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MP44; NO44; 35kDa; 2310006I24Rik; 5330402E05Rik
Summary
Enables identical protein binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in nucleus and plasma membrane. Predicted to be part of nuclear pore central transport channel and nuclear pore nuclear basket. Is expressed in cerebellum. Used to study intestinal pseudo-obstruction. Orthologous to human NUP35 (nucleoporin 35). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 15.4), whole brain E14.5 (RPKM 7.3) and 28 other tissues See more
Orthologs
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Genomic context

See Nup35 in Genome Data Viewer
Location:
2; 2 C3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (80469156..80490415)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (80638812..80660071)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 13688 Neighboring gene dual specificity phosphatase 19 Neighboring gene microRNA 684-1 Neighboring gene SMT3 suppressor of mif two 3 homolog 2 pseudogene Neighboring gene predicted gene, 36282 Neighboring gene predicted gene, 25420 Neighboring gene putative Eno1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transgenic (1) 
  • Targeted (2) 
  • Chemically induced (ENU) (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in NLS-bearing protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
 
involved_in nuclear pore organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nucleocytoplasmic transport NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear lamina ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear pore NAS
Non-traceable Author Statement
more info
PubMed 
part_of nuclear pore central transport channel IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of nuclear pore nuclear basket IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
nucleoporin NUP35
Names
35 kDa nucleoporin
mitotic phosphoprotein 44
nuclear pore complex protein Nup53

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190179.1NP_001177108.1  nucleoporin NUP35 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR/coding region and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK136109, AK145775, CA560987, DV653588
    UniProtKB/Swiss-Prot
    Q8R4R6
    Conserved Domains (1) summary
    cd12722
    Location:154227
    RRM_Nup53; RNA recognition motif in nucleoporin Nup53
  2. NM_027091.4NP_081367.1  nucleoporin NUP35 isoform 1

    See identical proteins and their annotated locations for NP_081367.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK136109, AK145775, BY272877
    Consensus CDS
    CCDS16179.1
    UniProtKB/Swiss-Prot
    Q8R4R6, Q9D7J2
    Related
    ENSMUSP00000028382.7, ENSMUST00000028382.13
    Conserved Domains (1) summary
    cd12722
    Location:171244
    RRM_Nup53; RNA recognition motif in nucleoporin Nup53

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    80469156..80490415
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)