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Commd10 COMM domain containing 10 [ Mus musculus (house mouse) ]

Gene ID: 69456, updated on 21-Mar-2023

Summary

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Official Symbol
Commd10provided by MGI
Official Full Name
COMM domain containing 10provided by MGI
Primary source
MGI:MGI:1916706
See related
Ensembl:ENSMUSG00000042705 AllianceGenome:MGI:1916706
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DRWMS2; VavCre; Vav-cre; Vav-iCre; Vav1-Cre; 2310003A05Rik; Tg(Vav1-icre)A2Kio
Summary
Predicted to be located in nucleoplasm. Orthologous to human COMMD10 (COMM domain containing 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 9.6), CNS E11.5 (RPKM 9.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Commd10 in Genome Data Viewer
Location:
18; 18 C
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (47091886..47221062)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (46958819..47087995)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene 3744 Neighboring gene predicted gene, 49974 Neighboring gene predicted gene, 22791 Neighboring gene heat shock protein 1 (chaperonin 10), related sequence 1 Neighboring gene ADP-ribosylation factor interacting protein 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deciphering hematopoietic stem cells in their niches: a critical appraisal of genetic models, lineage tracing, and imaging strategies. Joseph C, et al. Cell Stem Cell, 2013 Nov 7. PMID 24209759
  2. Promoter elements of vav drive transgene expression in vivo throughout the hematopoietic compartment. Ogilvy S, et al. Blood, 1999 Sep 15. PMID 10477714
  3. Intrinsic function of the peptidylarginine deiminase PADI4 is dispensable for normal haematopoiesis. Young C, et al. Biol Open, 2022 Jun 15. PMID 35603697, Free PMC Article
  4. Chronically Elevated O-GlcNAcylation Limits Nitric Oxide Production and Deregulates Specific Pro-Inflammatory Cytokines. Abramowitz LK, et al. Front Immunol, 2022. PMID 35432339, Free PMC Article
  5. Vangl2 Promotes Hematopoietic Stem Cell Expansion. Bouali S, et al. Front Cell Dev Biol, 2022. PMID 35399538, Free PMC Article

See all (492) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. COMMD10 inhibits HIF1alpha/CP loop to enhance ferroptosis and radiosensitivity by disrupting Cu-Fe balance in hepatocellular carcinoma.
    Title: COMMD10 inhibits HIF1α/CP loop to enhance ferroptosis and radiosensitivity by disrupting Cu-Fe balance in hepatocellular carcinoma.
  2. COMMD10 is critical for Kupffer cell survival and controls Ly6C(hi) monocyte differentiation and inflammation in the injured liver.
    Title: COMMD10 is critical for Kupffer cell survival and controls Ly6C(hi) monocyte differentiation and inflammation in the injured liver.
  3. Expression profile and bioinformatics analysis of COMMD10 in BALB/C mice and human.
    Title: Expression profile and bioinformatics analysis of COMMD10 in BALB/C mice and human.
  4. these results highlight COMMD10 as a negative regulator of Ly6Chi monocyte inflammasome activity during systemic inflammation
    Title: Impaired COMMD10-Mediated Regulation of Ly6C(hi) Monocyte-Driven Inflammation Disrupts Gut Barrier Function.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
COMM domain-containing protein 10
Names
Tg(Vav1-cre)1Kio
Tg(Vav1-cre)A2Kio
down-regulated in W/WV mouse stomach 2
mDRWMS2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178377.4 → NP_848464.1  COMM domain-containing protein 10

    See identical proteins and their annotated locations for NP_848464.1

    Status: PROVISIONAL

    Source sequence(s)
    AC117239, AC132100
    Consensus CDS
    CCDS29238.1
    UniProtKB/Swiss-Prot
    Q8JZY2
    UniProtKB/TrEMBL
    Q3TKN7
    Related
    ENSMUSP00000041650.8, ENSMUST00000049388.9
    Conserved Domains (1) summary
    cd04758
    Location:15 → 201
    Commd10; COMM_Domain containing protein 10. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    47091886..47221062
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526224.4 → XP_006526287.1  COMM domain-containing protein 10 isoform X1

    Conserved Domains (1) summary
    cd04758
    Location:15 → 174
    Commd10; COMM_Domain containing protein 10. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...

  2. XM_006526226.4 → XP_006526289.1  COMM domain-containing protein 10 isoform X3

    UniProtKB/TrEMBL
    A0A3Q4EHW7
    Related
    ENSMUSP00000157148.2, ENSMUST00000234961.2
    Conserved Domains (1) summary
    cd04758
    Location:15 → 171
    Commd10; COMM_Domain containing protein 10. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...

  3. XM_006526225.4 → XP_006526288.1  COMM domain-containing protein 10 isoform X2

    Conserved Domains (1) summary
    cl06336
    Location:15 → 122
    Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...

  4. XM_006526228.4 → XP_006526291.1  COMM domain-containing protein 10 isoform X5

    See identical proteins and their annotated locations for XP_006526291.1

    UniProtKB/TrEMBL
    A0A3Q4EII3
    Related
    ENSMUSP00000157358.2, ENSMUST00000234280.2
    Conserved Domains (1) summary
    cl06336
    Location:15 → 149
    Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...

  5. XM_006526227.4 → XP_006526290.1  COMM domain-containing protein 10 isoform X4

    Conserved Domains (1) summary
    cl06336
    Location:15 → 85
    Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...

  6. XM_006526229.4 → XP_006526292.1  COMM domain-containing protein 10 isoform X7

    See identical proteins and their annotated locations for XP_006526292.1

    UniProtKB/TrEMBL
    A0A3Q4EGT0
    Related
    ENSMUSP00000157146.2, ENSMUST00000234085.2
    Conserved Domains (1) summary
    cl06336
    Location:15 → 112
    Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...

  7. XM_036161272.1 → XP_036017165.1  COMM domain-containing protein 10 isoform X6

    Conserved Domains (1) summary
    cl06336
    Location:15 → 119
    Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8JZY2.1 GenPept UniProtKB/Swiss-Prot:Q8JZY2

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