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POMC proopiomelanocortin [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 694430, updated on 8-Apr-2026
Official Symbol
POMCprovided by VGNC
Official Full Name
proopiomelanocortinprovided by VGNC
Primary source
VGNC:VGNC:76218
See related
Ensembl:ENSMMUG00000055135
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
all
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Try the new Transcripts and proteins table
See POMC in Genome Data Viewer
Location:
chromosome: 13
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2025_08 current T2T-MMU8v2.0 (GCF_049350105.2) 13 NC_133418.1 (99843384..99851221)
103 previous assembly Mmul_10 (GCF_003339765.1) 13 NC_041766.1 (83809315..83817190)

Chromosome 13 - NC_133418.1Genomic Context describing neighboring genes Neighboring gene peptidyl-prolyl cis-trans isomerase A pseudogene Neighboring gene small nucleolar RNA U13 Neighboring gene EFR3 homolog B Neighboring gene uncharacterized LOC144333882 Neighboring gene succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial-like

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Effects of estradiol on cerebrospinal fluid levels of agouti-related protein in ovariectomized rhesus monkeys. Xiao E, et al. Endocrinology, 2010 Mar. PMID 20056830, Free PMC Article
  2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Estradiol increases the POMC to AgRP ratio in lumbar cerebrospinal fluid.
    Title: Effects of estradiol on cerebrospinal fluid levels of agouti-related protein in ovariectomized rhesus monkeys.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G protein-coupled receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of corticosterone secretion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in secretory granule IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
pro-opiomelanocortin
Names
pro-opiomelanocortin preproprotein
proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin)

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_049350105.2-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference T2T-MMU8v2.0

Genomic

  1. NC_133418.1 Reference T2T-MMU8v2.0

    Range
    99843384..99851221
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001082999.5 → XP_001082999.1  pro-opiomelanocortin

    See identical proteins and their annotated locations for XP_001082999.1

    UniProtKB/TrEMBL
    A0A5F8AUI4, G7N9J9
    Conserved Domains (3) summary
    pfam00976
    Location:216 → 234
    ACTH_domain; Corticotropin ACTH domain
    pfam08035
    Location:235 → 262
    Op_neuropeptide; Opioids neuropeptide
    pfam08384
    Location:28 → 70
    NPP; Pro-opiomelanocortin, N-terminal region
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials