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TCF15 transcription factor 15 [ Homo sapiens (human) ]

Gene ID: 6939, updated on 1-Jun-2020

Summary

Official Symbol
TCF15provided by HGNC
Official Full Name
transcription factor 15provided by HGNC
Primary source
HGNC:HGNC:11627
See related
Ensembl:ENSG00000125878 MIM:601010
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EC2; PARAXIS; bHLHa40
Summary
The protein encoded by this gene is found in the nucleus and may be involved in the early transcriptional regulation of patterning of the mesoderm. The encoded basic helix-loop-helix protein requires dimerization with another basic helix-loop-helix protein for efficient DNA binding. [provided by RefSeq, Jul 2008]
Expression
Biased expression in fat (RPKM 5.9), heart (RPKM 2.3) and 3 other tissues See more
Orthologs

Genomic context

See TCF15 in Genome Data Viewer
Location:
20p13
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (603993..610266, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (584637..590910, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene TBC1 domain family member 20 Neighboring gene casein kinase 2 alpha 1 Neighboring gene uncharacterized LOC107985387 Neighboring gene sulfiredoxin 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
developmental process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ear development IEA
Inferred from Electronic Annotation
more info
 
eating behavior IEA
Inferred from Electronic Annotation
more info
 
establishment of epithelial cell apical/basal polarity IEA
Inferred from Electronic Annotation
more info
 
mesenchymal to epithelial transition IEA
Inferred from Electronic Annotation
more info
 
mesoderm development TAS
Traceable Author Statement
more info
PubMed 
muscle organ morphogenesis IEA
Inferred from Electronic Annotation
more info
 
neuromuscular process controlling posture IEA
Inferred from Electronic Annotation
more info
 
paraxial mesoderm development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
post-anal tail morphogenesis IEA
Inferred from Electronic Annotation
more info
 
regulation of extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
respiratory system process IEA
Inferred from Electronic Annotation
more info
 
skeletal system morphogenesis IEA
Inferred from Electronic Annotation
more info
 
skin development IEA
Inferred from Electronic Annotation
more info
 
somitogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
RNA polymerase II transcription factor complex IEA
Inferred from Electronic Annotation
more info
 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transcription factor 15
Names
TCF-15
basic helix-loop-helix transcription factor 15
class A basic helix-loop-helix protein 40
protein bHLH-EC2
transcription factor 15 (basic helix-loop-helix)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004609.3NP_004600.2  transcription factor 15

    See identical proteins and their annotated locations for NP_004600.2

    Status: REVIEWED

    Source sequence(s)
    BC067836, U08336
    Consensus CDS
    CCDS33432.1
    UniProtKB/Swiss-Prot
    Q12870
    UniProtKB/TrEMBL
    A4LBB6, Q6NVX3
    Related
    ENSP00000246080.3, ENST00000246080.3
    Conserved Domains (1) summary
    pfam00010
    Location:73124
    HLH; Helix-loop-helix DNA-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    603993..610266 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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