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TCF12 transcription factor 12 [ Homo sapiens (human) ]

Gene ID: 6938, updated on 25-Nov-2025
Official Symbol
TCF12provided by HGNC
Official Full Name
transcription factor 12provided by HGNC
Primary source
HGNC:HGNC:11623
See related
Ensembl:ENSG00000140262 MIM:600480; AllianceGenome:HGNC:11623
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HEB; p64; CRS3; HH26; HTF4; TCF-12; bHLHb20; HsT17266
Summary
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 23.3), endometrium (RPKM 15.8) and 25 other tissues See more
Orthologs
mouse all
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See TCF12 in Genome Data Viewer
Location:
15q21.3
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (56918090..57291310)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (54721353..55094637)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (57210288..57583508)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene MPRA-validated peak2351 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9457 Neighboring gene NREP pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6467 Neighboring gene NANOG hESC enhancer GRCh37_chr15:57184049-57184608 Neighboring gene long intergenic non-protein coding RNA 3065 Neighboring gene TCF12 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6468 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6469 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6470 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6471 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6472 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:57269446-57269630 Neighboring gene VISTA enhancer hs357 Neighboring gene VISTA enhancer hs623 Neighboring gene MPRA-validated peak2352 silencer Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:57490067-57490736 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:57490737-57491406 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:57491407-57492076 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene 11 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9458 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9459 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9460 Neighboring gene small nucleolar RNA, C/D box 13D Neighboring gene ReSE screen-validated silencer GRCh37_chr15:57598867-57599070 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:57615704-57616211 Neighboring gene long intergenic non-protein coding RNA 926 Neighboring gene long intergenic non-protein coding RNA 1413

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Targeted Disruption of TCF12 Reveals HEB as Essential in Human Mesodermal Specification and Hematopoiesis. Li Y, et al. Stem Cell Reports, 2017 Sep 12. PMID 28803914, Free PMC Article
  2. Identification of a highly conserved module in E proteins required for in vivo helix-loop-helix dimerization. Goldfarb AN, et al. J Biol Chem, 1998 Jan 30. PMID 9446597
  3. Craniofacial morphology and growth in Muenke syndrome, Saethre-Chotzen syndrome, and TCF12-related craniosynostosis. Choi TM, et al. Clin Oral Investig, 2022 Mar. PMID 34904178, Free PMC Article
  4. Evaluation of dental maturity in Muenke syndrome, Saethre-Chotzen syndrome, and TCF12-related craniosynostosis. Choi TM, et al. Eur J Orthod, 2022 May 24. PMID 34424951, Free PMC Article
  5. miR-218-5p inhibits the malignant progression of glioma via targeting TCF12. Gu J, et al. Tumori, 2022 Aug. PMID 34121515

See all (147) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TCF12-regulated GRB7 facilitates the HER2+ breast cancer progression by activating Notch1 signaling pathway.
    Title: TCF12-regulated GRB7 facilitates the HER2+ breast cancer progression by activating Notch1 signaling pathway.
  2. Lncrna CASC15 Activated By TCF12 Promote Colorectal Cancer Progression via EMT.
    Title: Lncrna CASC15 Activated By TCF12 Promote Colorectal Cancer Progression via EMT.
  3. Nuclear Tubulin Enhances CXCR4 Transcription and Promotes Chemotaxis Through TCF12 Transcription Factor in human Hematopoietic Stem Cells.
    Title: Nuclear Tubulin Enhances CXCR4 Transcription and Promotes Chemotaxis Through TCF12 Transcription Factor in human Hematopoietic Stem Cells.
  4. RNA-binding protein DHX9 promotes glioma growth and tumor-associated macrophages infiltration via TCF12.
    Title: RNA-binding protein DHX9 promotes glioma growth and tumor-associated macrophages infiltration via TCF12.
  5. Circular RNA hsa_circ_0002938 (circCRIM1) promotes the progression of esophageal squamous cell carcinoma by upregulating transcription factor 12.
    Title: Circular RNA hsa_circ_0002938 (circCRIM1) promotes the progression of esophageal squamous cell carcinoma by upregulating transcription factor 12.
  6. Auricles Anomalies in Patients With a TCF12 Gene Mutation.
    Title: Auricles Anomalies in Patients With a TCF12 Gene Mutation.
  7. miR-218-5p inhibits the malignant progression of glioma via targeting TCF12.
    Title: miR-218-5p inhibits the malignant progression of glioma via targeting TCF12.
  8. Evaluation of dental maturity in Muenke syndrome, Saethre-Chotzen syndrome, and TCF12-related craniosynostosis.
    Title: Evaluation of dental maturity in Muenke syndrome, Saethre-Chotzen syndrome, and TCF12-related craniosynostosis.
  9. Long non-coding RNA GLIDR accelerates the tumorigenesis of lung adenocarcinoma by miR-1270/TCF12 axis.
    Title: Long non-coding RNA GLIDR accelerates the tumorigenesis of lung adenocarcinoma by miR-1270/TCF12 axis.
  10. Craniofacial morphology and growth in Muenke syndrome, Saethre-Chotzen syndrome, and TCF12-related craniosynostosis.
    Title: Craniofacial morphology and growth in Muenke syndrome, Saethre-Chotzen syndrome, and TCF12-related craniosynostosis.
Submit: New GeneRIF Correction See all GeneRIFs (44)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Desbuquois dysplasia 2
MedGen: C4014294 OMIM: 615777 GeneReviews: Not available
Compare labs
Hypogonadotropic hypogonadism 26 with or without anosmia
MedGen: C5676903 OMIM: 619718 GeneReviews: Not available
Compare labs
TCF12-related craniosynostosis
MedGen: C3715051 OMIM: 615314 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2023-08-16)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated 2023-08-16)

ClinGen Genome Curation PagePubMed

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Replication interactions

Interaction Pubs
Knockdown of transcription factor 12 (TCF12; HTF4) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr downregulates the gene expression of TCF12 in human monocyte-derived dendritic cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables E-box binding IEA
Inferred from Electronic Annotation
more info
  
enables HMG box domain binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables SMAD binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables bHLH transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables cAMP response element binding IEA
Inferred from Electronic Annotation
more info
  
enables cis-regulatory region sequence-specific DNA binding IC
Inferred by Curator
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in immune response TAS
Traceable Author Statement
more info
 PubMed 
involved_in muscle organ development TAS
Traceable Author Statement
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in nervous system development ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 PubMed 
involved_in response to gonadotropin-releasing hormone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
transcription factor 12
Names
DNA-binding protein HTF4
E-box-binding protein
class B basic helix-loop-helix protein 20
helix-loop-helix transcription factor 4
transcription factor HTF-4

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033851.2 RefSeqGene

    Range
    5555..376764
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001306219.3 → NP_001293148.1  transcription factor 12 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks multiple exon in the 5' UTR and 5' coding region and uses an alternate 5' most exon compared to variant 1. The encoded isoform (d) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC016525, AC090532
    Consensus CDS
    CCDS76760.1
    UniProtKB/TrEMBL
    B4DH96, F5GY10
    Related
    ENSP00000440017.1, ENST00000543579.5
    Conserved Domains (1) summary
    smart00353
    Location:437 → 490
    HLH; helix loop helix domain

  2. NM_001306220.3 → NP_001293149.1  transcription factor 12 isoform e

    See identical proteins and their annotated locations for NP_001293149.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has multiple differences in the 5' UTR and coding region compared to variant 1. The encoded isoform (e) is shorter and has a distict N-terminus compared to isoform a.
    Source sequence(s)
    AC016525, AC090532
    Consensus CDS
    CCDS76761.1
    UniProtKB/Swiss-Prot
    Q99081
    Related
    ENSP00000444696.1, ENST00000537840.5
    Conserved Domains (2) summary
    smart00353
    Location:347 → 400
    HLH; helix loop helix domain
    pfam10428
    Location:13 → 152
    SOG2; RAM signalling pathway protein

  3. NM_001322151.2 → NP_001309080.1  transcription factor 12 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC010999, AC016525, AC090511, AC090532
    Consensus CDS
    CCDS10160.1
    UniProtKB/TrEMBL
    B4DGI9
    Conserved Domains (1) summary
    smart00353
    Location:607 → 660
    HLH; helix loop helix domain

  4. NM_001322152.2 → NP_001309081.1  transcription factor 12 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC010999, AC016525, AC090511, AC090532
    UniProtKB/TrEMBL
    B4DGI9
    Related
    ENSP00000558383.1, ENST00000888324.1
    Conserved Domains (2) summary
    smart00353
    Location:606 → 659
    HLH; helix loop helix domain
    pfam09786
    Location:275 → 448
    CytochromB561_N; Cytochrome B561, N terminal

  5. NM_001322154.2 → NP_001309083.1  transcription factor 12 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC010999, AC016525, AC090511, AC090532
    UniProtKB/TrEMBL
    B4DH96
    Conserved Domains (2) summary
    smart00353
    Location:388 → 441
    HLH; helix loop helix domain
    pfam09786
    Location:56 → 229
    CytochromB561_N; Cytochrome B561, N terminal

  6. NM_001322156.2 → NP_001309085.1  transcription factor 12 isoform h

    Status: REVIEWED

    Source sequence(s)
    AC010999, AC016525, AC090511, AC090532
    UniProtKB/TrEMBL
    B4DGI9
    Conserved Domains (2) summary
    smart00353
    Location:549 → 602
    HLH; helix loop helix domain
    pfam09786
    Location:217 → 390
    CytochromB561_N; Cytochrome B561, N terminal

  7. NM_001322157.3 → NP_001309086.1  transcription factor 12 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC010999, AC016525, AC090511, AC090532
    Consensus CDS
    CCDS10159.1
    UniProtKB/Swiss-Prot
    B4E1W1, Q7Z3D9, Q86TC1, Q86VM2, Q99081
    UniProtKB/TrEMBL
    B4DGI9
    Related
    ENSP00000616045.1, ENST00000945986.1
    Conserved Domains (1) summary
    smart00353
    Location:583 → 636
    HLH; helix loop helix domain

  8. NM_001322158.2 → NP_001309087.1  transcription factor 12 isoform i

    Status: REVIEWED

    Source sequence(s)
    AC010999, AC016525, AC090511, AC090532
    UniProtKB/TrEMBL
    B4DGI9
    Related
    ENSP00000616051.1, ENST00000945992.1
    Conserved Domains (1) summary
    smart00353
    Location:525 → 578
    HLH; helix loop helix domain

  9. NM_001322159.3 → NP_001309088.1  transcription factor 12 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC010999, AC016525, AC090511, AC090532
    Consensus CDS
    CCDS10160.1
    UniProtKB/TrEMBL
    B4DGI9
    Related
    ENSP00000558391.1, ENST00000888332.1
    Conserved Domains (1) summary
    smart00353
    Location:607 → 660
    HLH; helix loop helix domain

  10. NM_001322161.2 → NP_001309090.1  transcription factor 12 isoform k

    Status: REVIEWED

    Source sequence(s)
    AC010999, AC016525, AC090511, AC090532
    UniProtKB/TrEMBL
    B4DGI9
    Related
    ENSP00000604253.1, ENST00000934194.1
    Conserved Domains (2) summary
    smart00353
    Location:606 → 659
    HLH; helix loop helix domain
    pfam09786
    Location:275 → 447
    CytochromB561_N; Cytochrome B561, N terminal

  11. NM_001322162.2 → NP_001309091.1  transcription factor 12 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC010999, AC016525, AC090511, AC090532
    Consensus CDS
    CCDS10160.1
    UniProtKB/TrEMBL
    B4DGI9
    Related
    ENSP00000604258.1, ENST00000934199.1
    Conserved Domains (1) summary
    smart00353
    Location:607 → 660
    HLH; helix loop helix domain

  12. NM_001322164.2 → NP_001309093.1  transcription factor 12 isoform j

    Status: REVIEWED

    Source sequence(s)
    AC010999, AC016525, AC090511, AC090532
    UniProtKB/TrEMBL
    B4DGI9
    Conserved Domains (1) summary
    smart00353
    Location:595 → 648
    HLH; helix loop helix domain

  13. NM_001322165.2 → NP_001309094.1  transcription factor 12 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC010999, AC016525, AC090511, AC090532
    Consensus CDS
    CCDS10159.1
    UniProtKB/Swiss-Prot
    B4E1W1, Q7Z3D9, Q86TC1, Q86VM2, Q99081
    UniProtKB/TrEMBL
    B4DGI9
    Related
    ENSP00000558388.1, ENST00000888329.1
    Conserved Domains (1) summary
    smart00353
    Location:583 → 636
    HLH; helix loop helix domain

  14. NM_003205.4 → NP_003196.1  transcription factor 12 isoform b

    See identical proteins and their annotated locations for NP_003196.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding region (compared to variant 1), resulting in a protein that maintains the reading frame but is shorter, compared to isoform a. Variants 3 and 4 encode the same isoform b.
    Source sequence(s)
    AC016525, BC051769, BU178185, M83233
    Consensus CDS
    CCDS10159.1
    UniProtKB/Swiss-Prot
    B4E1W1, Q7Z3D9, Q86TC1, Q86VM2, Q99081
    UniProtKB/TrEMBL
    B4DGI9
    Related
    ENSP00000267811.5, ENST00000267811.9
    Conserved Domains (1) summary
    smart00353
    Location:583 → 636
    HLH; helix loop helix domain

  15. NM_207036.2 → NP_996919.1  transcription factor 12 isoform a

    See identical proteins and their annotated locations for NP_996919.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 2 both encode the same isoform a.
    Source sequence(s)
    AC016525, BC050556, BK001049
    Consensus CDS
    CCDS10160.1
    UniProtKB/TrEMBL
    B4DGI9
    Related
    ENSP00000388940.2, ENST00000438423.6
    Conserved Domains (1) summary
    smart00353
    Location:607 → 660
    HLH; helix loop helix domain

  16. NM_207037.2 → NP_996920.1  transcription factor 12 isoform a

    See identical proteins and their annotated locations for NP_996920.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform a.
    Source sequence(s)
    AC016525, BC050556, BK001049, BU178185
    Consensus CDS
    CCDS10160.1
    UniProtKB/TrEMBL
    B4DGI9
    Related
    ENSP00000331057.6, ENST00000333725.10
    Conserved Domains (1) summary
    smart00353
    Location:607 → 660
    HLH; helix loop helix domain

  17. NM_207038.2 → NP_996921.1  transcription factor 12 isoform b

    See identical proteins and their annotated locations for NP_996921.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the coding region (compared to variant 1), resulting in a protein that maintains the reading frame but is shorter, compared to isoform a. Variants 3 and 4 encode the same isoform b.
    Source sequence(s)
    AC016525, BC051769, BK001049, M80627
    Consensus CDS
    CCDS10159.1
    UniProtKB/Swiss-Prot
    B4E1W1, Q7Z3D9, Q86TC1, Q86VM2, Q99081
    UniProtKB/TrEMBL
    B4DGI9
    Related
    ENSP00000453737.1, ENST00000557843.5
    Conserved Domains (1) summary
    smart00353
    Location:583 → 636
    HLH; helix loop helix domain

  18. NM_207040.2 → NP_996923.1  transcription factor 12 isoform c

    See identical proteins and their annotated locations for NP_996923.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has multiple differences in the 5' UTR and coding region compared to variant 1. This results in a shorter isoform (c) with a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AC016525, AC090532, AU120213, BC051769
    Consensus CDS
    CCDS42042.1
    UniProtKB/TrEMBL
    B4DH96
    Related
    ENSP00000342459.3, ENST00000343827.7
    Conserved Domains (1) summary
    smart00353
    Location:413 → 466
    HLH; helix loop helix domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    56918090..57291310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521960.4 → XP_011520262.1  transcription factor 12 isoform X1

    See identical proteins and their annotated locations for XP_011520262.1

    UniProtKB/TrEMBL
    B4DGI9
    Conserved Domains (2) summary
    smart00353
    Location:619 → 672
    HLH; helix loop helix domain
    pfam09786
    Location:287 → 460
    CytochromB561_N; Cytochrome B561, N terminal

  2. XM_047432971.1 → XP_047288927.1  transcription factor 12 isoform X3

    UniProtKB/TrEMBL
    B4DGI9

  3. XM_047432972.1 → XP_047288928.1  transcription factor 12 isoform X4

    UniProtKB/TrEMBL
    B4DGI9

  4. XM_047432973.1 → XP_047288929.1  transcription factor 12 isoform X5

    UniProtKB/TrEMBL
    B4DGI9
    Related
    ENSP00000558390.1, ENST00000888331.1

  5. XM_011521959.4 → XP_011520261.1  transcription factor 12 isoform X1

    See identical proteins and their annotated locations for XP_011520261.1

    UniProtKB/TrEMBL
    B4DGI9
    Conserved Domains (2) summary
    smart00353
    Location:619 → 672
    HLH; helix loop helix domain
    pfam09786
    Location:287 → 460
    CytochromB561_N; Cytochrome B561, N terminal

  6. XM_011521961.4 → XP_011520263.1  transcription factor 12 isoform X2

    UniProtKB/TrEMBL
    B4DGI9
    Conserved Domains (2) summary
    smart00353
    Location:618 → 671
    HLH; helix loop helix domain
    pfam09786
    Location:287 → 460
    CytochromB561_N; Cytochrome B561, N terminal

  7. XM_011521962.4 → XP_011520264.1  transcription factor 12 isoform X3

    UniProtKB/TrEMBL
    B4DGI9
    Conserved Domains (1) summary
    smart00353
    Location:595 → 648
    HLH; helix loop helix domain

  8. XM_011521963.4 → XP_011520265.1  transcription factor 12 isoform X4

    UniProtKB/TrEMBL
    B4DGI9
    Conserved Domains (1) summary
    smart00353
    Location:594 → 647
    HLH; helix loop helix domain

  9. XM_017022520.3 → XP_016878009.1  transcription factor 12 isoform X5

    UniProtKB/TrEMBL
    B4DGI9
    Related
    ENSP00000558380.1, ENST00000888321.1

  10. XM_047432977.1 → XP_047288933.1  transcription factor 12 isoform X9

    UniProtKB/TrEMBL
    B4DH96

  11. XM_047432978.1 → XP_047288934.1  transcription factor 12 isoform X11

  12. XM_047432975.1 → XP_047288931.1  transcription factor 12 isoform X7

    UniProtKB/TrEMBL
    B4DH96

  13. XM_047432976.1 → XP_047288932.1  transcription factor 12 isoform X8

    UniProtKB/TrEMBL
    B4DH96

  14. XM_047432974.1 → XP_047288930.1  transcription factor 12 isoform X6

    UniProtKB/TrEMBL
    B4DH96

  15. XM_011521969.2 → XP_011520271.1  transcription factor 12 isoform X8

    UniProtKB/TrEMBL
    B4DH96
    Conserved Domains (1) summary
    smart00353
    Location:412 → 465
    HLH; helix loop helix domain

  16. XM_011521966.3 → XP_011520268.1  transcription factor 12 isoform X10

    UniProtKB/TrEMBL
    B4DH96
    Conserved Domains (2) summary
    smart00353
    Location:371 → 424
    HLH; helix loop helix domain
    pfam09786
    Location:67 → 212
    CytochromB561_N; Cytochrome B561, N terminal

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    54721353..55094637
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054378670.1 → XP_054234645.1  transcription factor 12 isoform X1

    UniProtKB/TrEMBL
    B4DGI9

  2. XM_054378673.1 → XP_054234648.1  transcription factor 12 isoform X3

    UniProtKB/TrEMBL
    B4DGI9

  3. XM_054378675.1 → XP_054234650.1  transcription factor 12 isoform X4

    UniProtKB/TrEMBL
    B4DGI9

  4. XM_054378677.1 → XP_054234652.1  transcription factor 12 isoform X5

    UniProtKB/TrEMBL
    B4DGI9

  5. XM_054378669.1 → XP_054234644.1  transcription factor 12 isoform X1

    UniProtKB/TrEMBL
    B4DGI9

  6. XM_054378671.1 → XP_054234646.1  transcription factor 12 isoform X2

    UniProtKB/TrEMBL
    B4DGI9

  7. XM_054378672.1 → XP_054234647.1  transcription factor 12 isoform X3

    UniProtKB/TrEMBL
    B4DGI9

  8. XM_054378674.1 → XP_054234649.1  transcription factor 12 isoform X4

    UniProtKB/TrEMBL
    B4DGI9

  9. XM_054378676.1 → XP_054234651.1  transcription factor 12 isoform X5

    UniProtKB/TrEMBL
    B4DGI9

  10. XM_054378682.1 → XP_054234657.1  transcription factor 12 isoform X9

    UniProtKB/TrEMBL
    B4DH96

  11. XM_054378684.1 → XP_054234659.1  transcription factor 12 isoform X11

  12. XM_054378679.1 → XP_054234654.1  transcription factor 12 isoform X7

    UniProtKB/TrEMBL
    B4DH96

  13. XM_054378681.1 → XP_054234656.1  transcription factor 12 isoform X8

    UniProtKB/TrEMBL
    B4DH96

  14. XM_054378678.1 → XP_054234653.1  transcription factor 12 isoform X6

    UniProtKB/TrEMBL
    B4DH96

  15. XM_054378680.1 → XP_054234655.1  transcription factor 12 isoform X8

    UniProtKB/TrEMBL
    B4DH96

  16. XM_054378683.1 → XP_054234658.1  transcription factor 12 isoform X10

    UniProtKB/TrEMBL
    B4DH96
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99081.1 GenPept UniProtKB/Swiss-Prot:Q99081

Gene LinkOut

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