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Glrx2 glutaredoxin 2 [ Mus musculus (house mouse) ]

Gene ID: 69367, updated on 19-Jun-2024

Summary

Official Symbol
Glrx2provided by MGI
Official Full Name
glutaredoxin 2provided by MGI
Primary source
MGI:MGI:1916617
See related
Ensembl:ENSMUSG00000018196 AllianceGenome:MGI:1916617
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Grx2; 1700010P22Rik
Summary
Enables protein-disulfide reductase activity. Predicted to be involved in response to hydrogen peroxide and response to organic substance. Located in mitochondrion. Is expressed in several structures, including adrenal gland; alimentary system; genitourinary system; nervous system; and respiratory system. Orthologous to human GLRX2 (glutaredoxin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 6.6), frontal lobe adult (RPKM 6.2) and 28 other tissues See more
Orthologs
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Genomic context

See Glrx2 in Genome Data Viewer
Location:
1 F; 1 62.53 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (143614787..143625416)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (143739224..143749678)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene cell division cycle 73, Paf1/RNA polymerase II complex component Neighboring gene STARR-positive B cell enhancer ABC_E7755 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_02529 Neighboring gene predicted gene, 38658 Neighboring gene predicted gene, 46161 Neighboring gene Ro60, Y RNA binding protein Neighboring gene STARR-positive B cell enhancer ABC_E1564 Neighboring gene STARR-positive B cell enhancer ABC_E2564 Neighboring gene predicted gene, 25663 Neighboring gene ubiquitin carboxyl-terminal esterase L5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein-disulfide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-disulfide reductase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glutaredoxin-2, mitochondrial
Names
thioltransferase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038592.1NP_001033681.1  glutaredoxin-2, mitochondrial isoform a

    See identical proteins and their annotated locations for NP_001033681.1

    Status: VALIDATED

    Source sequence(s)
    AK005853, AL592403, BY226480
    Consensus CDS
    CCDS15343.1
    UniProtKB/Swiss-Prot
    Q923X4, Q9DAG8, Q9JHY6
    UniProtKB/TrEMBL
    A2A5W4
    Related
    ENSMUSP00000141022.2, ENSMUST00000185362.7
    Conserved Domains (1) summary
    cd03419
    Location:61142
    GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...
  2. NM_001038593.1NP_001033682.1  glutaredoxin-2, mitochondrial isoform b

    See identical proteins and their annotated locations for NP_001033682.1

    Status: VALIDATED

    Source sequence(s)
    AK005853, AL592403
    Consensus CDS
    CCDS15344.1
    UniProtKB/TrEMBL
    Q3UQ95
    Related
    ENSMUSP00000121665.2, ENSMUST00000145969.8
    Conserved Domains (1) summary
    cd03419
    Location:28109
    GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...
  3. NM_001038594.1NP_001033683.1  glutaredoxin-2, mitochondrial isoform b

    See identical proteins and their annotated locations for NP_001033683.1

    Status: VALIDATED

    Source sequence(s)
    AK005853, AK142654, AL592403
    Consensus CDS
    CCDS15344.1
    UniProtKB/TrEMBL
    Q3UQ95
    Related
    ENSMUSP00000121010.2, ENSMUST00000129653.3
    Conserved Domains (1) summary
    cd03419
    Location:28109
    GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...
  4. NM_023505.2NP_075994.2  glutaredoxin-2, mitochondrial isoform b

    See identical proteins and their annotated locations for NP_075994.2

    Status: VALIDATED

    Source sequence(s)
    AK005853, AL592403
    Consensus CDS
    CCDS15344.1
    UniProtKB/TrEMBL
    Q3UQ95
    Related
    ENSMUSP00000107588.4, ENSMUST00000111957.10
    Conserved Domains (1) summary
    cd03419
    Location:28109
    GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    143614787..143625416
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529856.3XP_006529919.1  glutaredoxin-2, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006529919.1

    UniProtKB/TrEMBL
    Q3UQ95
    Conserved Domains (1) summary
    cd03419
    Location:28109
    GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...
  2. XM_006529855.5XP_006529918.2  glutaredoxin-2, mitochondrial isoform X1

  3. XM_011248068.3XP_011246370.1  glutaredoxin-2, mitochondrial isoform X3

    Conserved Domains (1) summary
    cd03419
    Location:19100
    GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...