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ZEB1 zinc finger E-box binding homeobox 1 [ Homo sapiens (human) ]

Gene ID: 6935, updated on 17-Jun-2018
Official Symbol
ZEB1provided by HGNC
Official Full Name
zinc finger E-box binding homeobox 1provided by HGNC
Primary source
HGNC:HGNC:11642
See related
Ensembl:ENSG00000148516 MIM:189909; Vega:OTTHUMG00000017907
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BZP; TCF8; AREB6; FECD6; NIL2A; PPCD3; ZFHEP; ZFHX1A; DELTAEF1
Summary
This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2010]
Expression
Ubiquitous expression in endometrium (RPKM 12.8), brain (RPKM 12.1) and 23 other tissues See more
Orthologs
See ZEB1 in Genome Data Viewer
Location:
10p11.22
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (31318495..31529814)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (31607825..31818742)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376481 Neighboring gene uncharacterized LOC105376483 Neighboring gene uncharacterized LOC101929352 Neighboring gene RNA, 5S ribosomal pseudogene 309 Neighboring gene ZEB1 antisense RNA 1 Neighboring gene putative UPF0607 protein FLJ37424 Neighboring gene serine palmitoyltransferase long chain base subunit 1 pseudogene 1 Neighboring gene uncharacterized LOC105376484 Neighboring gene glutamate dehydrogenase 1 pseudogene 5 Neighboring gene uncharacterized LOC101929951

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Corneal dystrophy, Fuchs endothelial, 6
MedGen: C2750448 OMIM: 613270 GeneReviews: Not available
Compare labs
Posterior polymorphous corneal dystrophy 3
MedGen: C1836724 OMIM: 609141 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef upregulates the expression of transcription factor 8 in HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC133261

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cartilage development IEA
Inferred from Electronic Annotation
more info
 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
cellular response to amino acid stimulus IEA
Inferred from Electronic Annotation
more info
 
central nervous system development IEA
Inferred from Electronic Annotation
more info
 
cochlea morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
embryonic camera-type eye morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic skeletal system morphogenesis IEA
Inferred from Electronic Annotation
more info
 
immune response TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of endothelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
pattern specification process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of T cell differentiation in thymus IEA
Inferred from Electronic Annotation
more info
 
regulation of mesenchymal cell proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of smooth muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
regulation of transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
semicircular canal morphogenesis IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
zinc finger E-box-binding homeobox 1
Names
delta-crystallin enhancer binding factor 1
negative regulator of IL2
posterior polymorphous corneal dystrophy 3
transcription factor 8 (represses interleukin 2 expression)
zinc finger homeodomain enhancer-binding protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017048.1 RefSeqGene

    Range
    5001..215642
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001128128.2NP_001121600.1  zinc finger E-box-binding homeobox 1 isoform a

    See identical proteins and their annotated locations for NP_001121600.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AI086650, AK311187, AK311557, AK314683, AL831979, BQ003893, BX111519, U12170
    Consensus CDS
    CCDS44370.1
    UniProtKB/Swiss-Prot
    P37275
    UniProtKB/TrEMBL
    B2RBI8
    Related
    ENSP00000391612.2, ENST00000446923.6
    Conserved Domains (5) summary
    smart00389
    Location:577613
    HOX; Homeodomain
    COG5048
    Location:913966
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:890910
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:224246
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:930955
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001174093.1NP_001167564.1  zinc finger E-box-binding homeobox 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This variant also lacks an in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (c) is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AI086650, AL831979, BC112392, BQ003893, BX111519, DB442432, DC299346
    Consensus CDS
    CCDS53506.1
    UniProtKB/Swiss-Prot
    P37275
    Related
    ENSP00000452787.1, OTTHUMP00000248673, ENST00000560721.6, OTTHUMT00000419086
    Conserved Domains (5) summary
    smart00389
    Location:573609
    HOX; Homeodomain
    COG5048
    Location:909962
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:886906
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:220242
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:926951
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001174094.1NP_001167565.1  zinc finger E-box-binding homeobox 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform d), compared to isoform a.
    Source sequence(s)
    AI086650, AK311116, AK311187, AK311557, AK314683, AL831979, BQ003893, BX111519, U12170
    UniProtKB/Swiss-Prot
    P37275
    UniProtKB/TrEMBL
    B2RBI8
    Conserved Domains (5) summary
    smart00389
    Location:576612
    HOX; Homeodomain
    COG5048
    Location:912965
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:889909
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:223245
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:929954
    zf-H2C2_2; Zinc-finger double domain
  4. NM_001174095.1NP_001167566.1  zinc finger E-box-binding homeobox 1 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This variant also lacks an in-frame exon and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (e) is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AI086650, AK300830, AK314683, AL831979, BQ003893, BX111519, DB442432, DC299346, U12170
    Consensus CDS
    CCDS53507.1
    UniProtKB/Swiss-Prot
    P37275
    UniProtKB/TrEMBL
    B2RBI8
    Related
    ENSP00000444891.2, OTTHUMP00000248675, ENST00000542815.7, OTTHUMT00000419088
    Conserved Domains (5) summary
    smart00389
    Location:526562
    HOX; Homeodomain
    COG5048
    Location:862915
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:839859
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:173195
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:879904
    zf-H2C2_2; Zinc-finger double domain
  5. NM_001174096.1NP_001167567.1  zinc finger E-box-binding homeobox 1 isoform f

    See identical proteins and their annotated locations for NP_001167567.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (f) is longer and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AI086650, AL831979, BC112392, BQ003893, BX111519, DB442432, DC299346
    Consensus CDS
    CCDS53505.1
    UniProtKB/Swiss-Prot
    P37275
    Related
    ENSP00000354487.5, ENST00000361642.9
    Conserved Domains (5) summary
    smart00389
    Location:594630
    HOX; Homeodomain
    COG5048
    Location:930983
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:907927
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:241263
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:947972
    zf-H2C2_2; Zinc-finger double domain
  6. NM_001323638.1NP_001310567.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variants 4, 5, and 10-36, encodes isoform g.
    Source sequence(s)
    AL161935, AL355148, BX647794
    Conserved Domains (4) summary
    smart00389
    Location:375411
    HOX; Homeodomain
    sd00017
    Location:688708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2244
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728753
    zf-H2C2_2; Zinc-finger double domain
  7. NM_001323641.1NP_001310570.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 3, 5, and 10-36, encodes isoform g.
    Source sequence(s)
    AK294775, AL117340, AL161935
    UniProtKB/TrEMBL
    B4DGU2
    Conserved Domains (4) summary
    smart00389
    Location:375411
    HOX; Homeodomain
    sd00017
    Location:688708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2244
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728753
    zf-H2C2_2; Zinc-finger double domain
  8. NM_001323642.1NP_001310571.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variants 3, 4, and 10-36, encodes isoform g.
    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    Conserved Domains (4) summary
    smart00389
    Location:375411
    HOX; Homeodomain
    sd00017
    Location:688708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2244
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728753
    zf-H2C2_2; Zinc-finger double domain
  9. NM_001323643.1NP_001310572.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 3-5 and 11-36, encodes isoform g.
    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    Conserved Domains (4) summary
    smart00389
    Location:375411
    HOX; Homeodomain
    sd00017
    Location:688708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2244
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728753
    zf-H2C2_2; Zinc-finger double domain
  10. NM_001323644.1NP_001310573.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variants 3-5, 10, and 12-36, encodes isoform g.
    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    Conserved Domains (4) summary
    smart00389
    Location:375411
    HOX; Homeodomain
    sd00017
    Location:688708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2244
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728753
    zf-H2C2_2; Zinc-finger double domain
  11. NM_001323645.1NP_001310574.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 3-5, 10-11, and 13-36, encodes isoform g.
    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    Conserved Domains (4) summary
    smart00389
    Location:375411
    HOX; Homeodomain
    sd00017
    Location:688708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2244
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728753
    zf-H2C2_2; Zinc-finger double domain
  12. NM_001323646.1NP_001310575.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 3-5, 10-12, and 14-36, encodes isoform g.
    Source sequence(s)
    AK311372, AL117340, AL161935, AL355148
    Conserved Domains (4) summary
    smart00389
    Location:375411
    HOX; Homeodomain
    sd00017
    Location:688708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2244
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728753
    zf-H2C2_2; Zinc-finger double domain
  13. NM_001323647.1NP_001310576.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 3-5, 10-13, and 15-36, encodes isoform g.
    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    Conserved Domains (4) summary
    smart00389
    Location:375411
    HOX; Homeodomain
    sd00017
    Location:688708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2244
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728753
    zf-H2C2_2; Zinc-finger double domain
  14. NM_001323648.1NP_001310577.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variants 3-5, 10-14, and 16-36, encodes isoform g.
    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    Conserved Domains (4) summary
    smart00389
    Location:375411
    HOX; Homeodomain
    sd00017
    Location:688708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2244
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728753
    zf-H2C2_2; Zinc-finger double domain
  15. NM_001323649.1NP_001310578.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variants 3-5, 10-15, and 17-36, encodes isoform g.
    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    Conserved Domains (4) summary
    smart00389
    Location:375411
    HOX; Homeodomain
    sd00017
    Location:688708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2244
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728753
    zf-H2C2_2; Zinc-finger double domain
  16. NM_001323650.1NP_001310579.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variants 3-5, 10-16, and 18-36, encodes isoform g.
    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    Conserved Domains (4) summary
    smart00389
    Location:375411
    HOX; Homeodomain
    sd00017
    Location:688708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2244
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728753
    zf-H2C2_2; Zinc-finger double domain
  17. NM_001323651.1NP_001310580.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variants 3-5, 10-17, and 19-36, encodes isoform g.
    Source sequence(s)
    AK307510, AL117340, AL158080, AL161935
    Conserved Domains (4) summary
    smart00389
    Location:375411
    HOX; Homeodomain
    sd00017
    Location:688708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2244
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728753
    zf-H2C2_2; Zinc-finger double domain
  18. NM_001323652.1NP_001310581.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19), as well as variants 3-5, 10-18, and 20-36, encodes isoform g.
    Source sequence(s)
    AL117340, AL161935, AL355148, DB276952
    Conserved Domains (4) summary
    smart00389
    Location:375411
    HOX; Homeodomain
    sd00017
    Location:688708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2244
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728753
    zf-H2C2_2; Zinc-finger double domain
  19. NM_001323653.1NP_001310582.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20), as well as variants 3-5, 10-19, and 21-36, encodes isoform g.
    Source sequence(s)
    AL117340, AL161935, AL355148, AL831979
    Conserved Domains (4) summary
    smart00389
    Location:375411
    HOX; Homeodomain
    sd00017
    Location:688708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2244
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728753
    zf-H2C2_2; Zinc-finger double domain
  20. NM_001323654.1NP_001310583.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21), as well as variants 3-5, 10-20, and 22-36, encodes isoform g.
    Source sequence(s)
    AK308822, AL117340, AL161935, AL355148
    Conserved Domains (4) summary
    smart00389
    Location:375411
    HOX; Homeodomain
    sd00017
    Location:688708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2244
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728753
    zf-H2C2_2; Zinc-finger double domain
  21. NM_001323655.1NP_001310584.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22), as well as variants 3-5, 10-21, and 23-36, encodes isoform g.
    Source sequence(s)
    AL117340, AL161935, AL355148, BX954549
    Conserved Domains (4) summary
    smart00389
    Location:375411
    HOX; Homeodomain
    sd00017
    Location:688708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2244
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728753
    zf-H2C2_2; Zinc-finger double domain
  22. NM_001323656.1NP_001310585.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23), as well as variants 3-5, 10-22, and 24-36, encodes isoform g.
    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    Conserved Domains (4) summary
    smart00389
    Location:375411
    HOX; Homeodomain
    sd00017
    Location:688708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2244
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728753
    zf-H2C2_2; Zinc-finger double domain
  23. NM_001323657.1NP_001310586.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24), as well as variants 3-5, 10-23, and 25-36, encodes isoform g.
    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    Conserved Domains (4) summary
    smart00389
    Location:375411
    HOX; Homeodomain
    sd00017
    Location:688708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2244
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728753
    zf-H2C2_2; Zinc-finger double domain
  24. NM_001323658.1NP_001310587.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25), as well as variants 3-5, 10-24, and 26-36, encodes isoform g.
    Source sequence(s)
    AL161935, AL355148, DC403144
    Conserved Domains (4) summary
    smart00389
    Location:375411
    HOX; Homeodomain
    sd00017
    Location:688708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2244
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728753
    zf-H2C2_2; Zinc-finger double domain
  25. NM_001323659.1NP_001310588.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (26), as well as variants 3-5, 10-25, and 27-36, encodes isoform g.
    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    Conserved Domains (4) summary
    smart00389
    Location:375411
    HOX; Homeodomain
    sd00017
    Location:688708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2244
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728753
    zf-H2C2_2; Zinc-finger double domain
  26. NM_001323660.1NP_001310589.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (27), as well as variants 3-5, 10-26, and 28-36, encodes isoform g.
    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    Conserved Domains (4) summary
    smart00389
    Location:375411
    HOX; Homeodomain
    sd00017
    Location:688708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2244
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728753
    zf-H2C2_2; Zinc-finger double domain
  27. NM_001323661.1NP_001310590.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (28), as well as variants 3-5, 10-27, and 29-36, encodes isoform g.
    Source sequence(s)
    AK309399, AL158080, AL161935, AL355148, DC375708
    Conserved Domains (4) summary
    smart00389
    Location:375411
    HOX; Homeodomain
    sd00017
    Location:688708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2244
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728753
    zf-H2C2_2; Zinc-finger double domain
  28. NM_001323662.1NP_001310591.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (29), as well as variants 3-5, 10-28, and 30-36, encodes isoform g.
    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    Conserved Domains (4) summary
    smart00389
    Location:375411
    HOX; Homeodomain
    sd00017
    Location:688708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2244
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728753
    zf-H2C2_2; Zinc-finger double domain
  29. NM_001323663.1NP_001310592.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (30), as well as variants 3-5, 10-29, and 31-36, encodes isoform g.
    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    Conserved Domains (4) summary
    smart00389
    Location:375411
    HOX; Homeodomain
    sd00017
    Location:688708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2244
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728753
    zf-H2C2_2; Zinc-finger double domain
  30. NM_001323664.1NP_001310593.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (31), as well as variants 3-5, 10-30, and 32-36, encodes isoform g.
    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    Conserved Domains (4) summary
    smart00389
    Location:375411
    HOX; Homeodomain
    sd00017
    Location:688708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2244
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728753
    zf-H2C2_2; Zinc-finger double domain
  31. NM_001323665.1NP_001310594.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (32), as well as variants 3-5, 10-31, and 33-36, encodes isoform g.
    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    Conserved Domains (4) summary
    smart00389
    Location:375411
    HOX; Homeodomain
    sd00017
    Location:688708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2244
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728753
    zf-H2C2_2; Zinc-finger double domain
  32. NM_001323666.1NP_001310595.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (33), as well as variants 3-5, 10-32, and 34-36, encodes isoform g.
    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    Conserved Domains (4) summary
    smart00389
    Location:375411
    HOX; Homeodomain
    sd00017
    Location:688708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2244
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728753
    zf-H2C2_2; Zinc-finger double domain
  33. NM_001323671.1NP_001310600.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (34), as well as variants 3-5, 10-33, 35, and 36, encodes isoform g.
    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    Conserved Domains (4) summary
    smart00389
    Location:375411
    HOX; Homeodomain
    sd00017
    Location:688708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2244
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728753
    zf-H2C2_2; Zinc-finger double domain
  34. NM_001323672.1NP_001310601.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (35), as well as variants 3-5, 10-34, and 36, encodes isoform g.
    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    Conserved Domains (4) summary
    smart00389
    Location:375411
    HOX; Homeodomain
    sd00017
    Location:688708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2244
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728753
    zf-H2C2_2; Zinc-finger double domain
  35. NM_001323673.1NP_001310602.1  zinc finger E-box-binding homeobox 1 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (36), as well as variants 3-5 and 10-35, encodes isoform g.
    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
    Conserved Domains (4) summary
    smart00389
    Location:375411
    HOX; Homeodomain
    sd00017
    Location:688708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2244
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728753
    zf-H2C2_2; Zinc-finger double domain
  36. NM_001323674.1NP_001310603.1  zinc finger E-box-binding homeobox 1 isoform h

    Status: REVIEWED

    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
  37. NM_001323675.1NP_001310604.1  zinc finger E-box-binding homeobox 1 isoform i

    Status: REVIEWED

    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
  38. NM_001323676.1NP_001310605.1  zinc finger E-box-binding homeobox 1 isoform j

    Status: REVIEWED

    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
  39. NM_001323677.1NP_001310606.1  zinc finger E-box-binding homeobox 1 isoform k

    Status: REVIEWED

    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
  40. NM_001323678.1NP_001310607.1  zinc finger E-box-binding homeobox 1 isoform l

    Status: REVIEWED

    Source sequence(s)
    AL117340, AL158080, AL161935, AL355148
  41. NM_030751.5NP_110378.3  zinc finger E-box-binding homeobox 1 isoform b

    See identical proteins and their annotated locations for NP_110378.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as Zfhx1a-1) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This variant also uses an alternate in-frame splice site in the 5' coding region, compared to variant 1.The encoded isoform (b) is longer and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AI086650, AK314683, AL831979, BQ003893, BX111519, DB442432, DC299346, U12170
    Consensus CDS
    CCDS7169.1
    UniProtKB/Swiss-Prot
    P37275
    UniProtKB/TrEMBL
    B2RBI8
    Related
    ENSP00000319248.9, OTTHUMP00000248671, ENST00000320985.14, OTTHUMT00000419083
    Conserved Domains (5) summary
    smart00389
    Location:593629
    HOX; Homeodomain
    COG5048
    Location:929982
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:906926
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:240262
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:946971
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    31318495..31529814
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717498.2XP_006717561.1  zinc finger E-box-binding homeobox 1 isoform X1

    See identical proteins and their annotated locations for XP_006717561.1

    Conserved Domains (4) summary
    smart00389
    Location:375411
    HOX; Homeodomain
    sd00017
    Location:688708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2244
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728753
    zf-H2C2_2; Zinc-finger double domain
  2. XM_017016597.1XP_016872086.1  zinc finger E-box-binding homeobox 1 isoform X1

    Conserved Domains (4) summary
    smart00389
    Location:375411
    HOX; Homeodomain
    sd00017
    Location:688708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2244
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728753
    zf-H2C2_2; Zinc-finger double domain
  3. XM_011519643.2XP_011517945.1  zinc finger E-box-binding homeobox 1 isoform X1

    See identical proteins and their annotated locations for XP_011517945.1

    Conserved Domains (4) summary
    smart00389
    Location:375411
    HOX; Homeodomain
    sd00017
    Location:688708
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2244
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728753
    zf-H2C2_2; Zinc-finger double domain
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