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MIR581 microRNA 581 [ Homo sapiens (human) ]

Gene ID: 693166, updated on 17-Jun-2024


Official Symbol
MIR581provided by HGNC
Official Full Name
microRNA 581provided by HGNC
Primary source
See related
Ensembl:ENSG00000207627 miRBase:MI0003588; AllianceGenome:HGNC:32837
Gene type
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIRN581; hsa-mir-581
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

See MIR581 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (53951504..53951599, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (54779032..54779127, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (53247334..53247429, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr5:53157616-53157824 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:53178032-53179231 Neighboring gene argininosuccinate synthetase 1 pseudogene 9 Neighboring gene RNA, U6 small nuclear 272, pseudogene Neighboring gene ADP ribosylation factor like GTPase 15 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:53313399-53314173 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:53314174-53314947 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:53315686-53316592 Neighboring gene RNA, 7SL, cytoplasmic 801, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr5:53476360-53476866 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:53592529-53593029 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:53600502-53601165 Neighboring gene CRISPRi-validated cis-regulatory element chr5.1314 Neighboring gene GATA motif-containing MPRA enhancer 36 Neighboring gene long intergenic non-protein coding RNA 1033 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22548 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22549 Neighboring gene ribosomal protein L37 pseudogene 25

Genomic regions, transcripts, and products


Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in miRNA-mediated post-transcriptional gene silencing IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
part_of RISC complex IEA
Inferred from Electronic Annotation
more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.


  1. NR_030307.1 RNA Sequence


    Source sequence(s)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    53951504..53951599 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0


  1. NC_060929.1 Alternate T2T-CHM13v2.0

    54779032..54779127 complement
    GenBank, FASTA, Sequence Viewer (Graphics)