Izumo3 IZUMO family member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Izumo3provided by MGI
Official Full Name: IZUMO family member 3provided by MGI
Primary source: MGI:MGI:1916564
See related: Ensembl:ENSMUSG00000028533 AllianceGenome:MGI:1916564
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1700011H22Rik
Summary: Enables protein homodimerization activity. Involved in acrosome assembly. Located in inner acrosomal membrane. Orthologous to human IZUMO3 (IZUMO family member 3). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Restricted expression toward testis adult (RPKM 9.1) See more
Orthologs: human all
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Genomic context

Location:: 4 C5; 4 43.16 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (92032555..92035462, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (92144318..92147225, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IZUMO family member 3, IZUMO3, is involved in male fertility through the acrosome formation.
Title: IZUMO family member 3, IZUMO3, is involved in male fertility through the acrosome formation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in acrosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in inner acrosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: izumo sperm-egg fusion protein 3

Names: transmembrane protein C9orf134

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027034.1 → NP_081310.1 izumo sperm-egg fusion protein 3 precursor

See identical proteins and their annotated locations for NP_081310.1

Status: VALIDATED

Source sequence(s)

AL807382

Consensus CDS

CCDS51231.1

UniProtKB/Swiss-Prot

A6PWV3, Q9DAG1

Related

ENSMUSP00000102725.2, ENSMUST00000107108.8

Conserved Domains (1) summary

pfam15005
Location:23 → 164

IZUMO; Izumo sperm-egg fusion, Ig domain-associated

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

92032555..92035462 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017320383.2 → XP_017175872.1 izumo sperm-egg fusion protein 3 isoform X1

Conserved Domains (1) summary

pfam15005
Location:23 → 164

IZUMO; Izumo sperm-egg fusion, Ig domain-associated