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MIR33B microRNA 33b [ Homo sapiens (human) ]

Gene ID: 693120, updated on 22-Mar-2021

Summary

Official Symbol
MIR33Bprovided by HGNC
Official Full Name
microRNA 33bprovided by HGNC
Primary source
HGNC:HGNC:32791
See related
Ensembl:ENSG00000207839 MIM:613486; miRBase:MI0003646
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIRN33B; mir-33b; hsa-mir-33b
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

See MIR33B in Genome Data Viewer
Location:
17p11.2
Exon count:
1
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (17813836..17813931, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (17717150..17717245, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene retinoic acid induced 1 Neighboring gene Smith-Magenis syndrome chromosome region, candidate 5 Neighboring gene microRNA 6777 Neighboring gene sterol regulatory element binding transcription factor 1 Neighboring gene target of myb1 like 2 membrane trafficking protein Neighboring gene uncharacterized LOC107984989 Neighboring gene brain protein I3 pseudogene 3 Neighboring gene dynein regulatory complex subunit 3

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cholesterol homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
gene silencing by miRNA IEA
Inferred from Electronic Annotation
more info
 
gene silencing by miRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cholesterol efflux IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of high-density lipoprotein particle clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_030361.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AC122129
    Related
    ENST00000385104.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    17813836..17813931 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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