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ELOA elongin A [ Homo sapiens (human) ]

Gene ID: 6924, updated on 6-Sep-2021

Summary

Official Symbol
ELOAprovided by HGNC
Official Full Name
elongin Aprovided by HGNC
Primary source
HGNC:HGNC:11620
See related
Ensembl:ENSG00000011007 MIM:600786
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIII; TCEB3; TCEB3A; SIII p110
Summary
This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lung (RPKM 15.9), thyroid (RPKM 14.1) and 25 other tissues See more
Orthologs
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Genomic context

See ELOA in Genome Data Viewer
Location:
1p36.11
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (23743471..23762059)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (24069856..24088549)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene elongation factor 1-alpha-like Neighboring gene ribosomal protein L11 Neighboring gene ELOA antisense RNA 1 Neighboring gene PITH domain containing 1 Neighboring gene uncharacterized LOC105376860 Neighboring gene lysophospholipase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of transcription elongation factor B (SIII), polypeptide 3 (TCEB3) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed
Knockdown of transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A; TCEB3) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef expression in HeLa cells upregulates transcription elongation factor B (SIII; elongin A) expression PubMed
Tat tat The C-terminal 34 residues (1329-1362) of BRD4 are crucial for interaction with P-TEFb. Overexpression of the BRD4 P-TEFb-interacting domain disrupts the interaction between HIV-1 Tat and P-TEFb PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38760, FLJ42849

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of elongin complex IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in site of DNA damage ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
elongin-A
Names
RNA polymerase II transcription factor SIII subunit A1
elongin 110 kDa subunit
transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)
transcription elongation factor B alpha subunit
transcription elongation factor B polypeptide 3
transcription elongation factor B subunit 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003198.3NP_003189.3  elongin-A

    Status: REVIEWED

    Source sequence(s)
    AL031295
    Consensus CDS
    CCDS239.2
    Related
    ENSP00000484196.1, ENST00000613537.4
    Conserved Domains (3) summary
    cd00183
    Location:3776
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
    TIGR01385
    Location:37127
    TFSII; transcription elongation factor S-II
    pfam06881
    Location:566664
    Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    23743471..23762059
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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