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Qrich1 glutamine-rich 1 [ Mus musculus (house mouse) ]

Gene ID: 69232, updated on 26-Sep-2022

Summary

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Official Symbol
Qrich1provided by MGI
Official Full Name
glutamine-rich 1provided by MGI
Primary source
MGI:MGI:1916482
See related
Ensembl:ENSMUSG00000006673 AllianceGenome:MGI:1916482
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
b2b2404Clo; 2610028H07Rik
Summary
Predicted to enable DNA binding activity. Involved in response to endoplasmic reticulum stress. Acts upstream of or within kidney development. Predicted to be located in nucleoplasm. Is expressed in female reproductive system and urinary system. Orthologous to human QRICH1 (glutamine rich 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 54.1), ovary adult (RPKM 39.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Qrich1 in Genome Data Viewer
Location:
9; 9 F2
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (108394010..108437366)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108516982..108560167)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 19 Neighboring gene glutaminyl-tRNA synthetase Neighboring gene inosine monophosphate dehydrogenase 2 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. QRICH1 mutations cause a chondrodysplasia with developmental delay. Lui JC, et al. Clin Genet, 2019 Jan. PMID 30281152, Free PMC Article
  2. QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis. You K, et al. Science, 2021 Jan 1. PMID 33384352, Free PMC Article
  3. Genetic link between renal birth defects and congenital heart disease. San Agustin JT, et al. Nat Commun, 2016 Mar 22. PMID 27002738, Free PMC Article
  4. Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Nakahara M, et al. Mamm Genome, 2013 Jun. PMID 23604909
  5. Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Li Y, et al. Nature, 2015 May 28. PMID 25807483, Free PMC Article

See all (32) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis.
    Title: QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Chemically induced (ENU) (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in PERK-mediated unfolded protein response ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum unfolded protein response ISO
Inferred from Sequence Orthology
more info
  
involved_in integrated stress response signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to unfolded protein IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transcriptional regulator QRICH1; glutamine-rich protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114119.1 → NP_001107591.1  transcriptional regulator QRICH1

    See identical proteins and their annotated locations for NP_001107591.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK151491, BB851544, BF658891, CT010508
    Consensus CDS
    CCDS52927.1
    UniProtKB/Swiss-Prot
    Q3UA37
    UniProtKB/TrEMBL
    A0A8C6I0G0, G3X8R5
    Related
    ENSMUSP00000006851.9, ENSMUST00000006851.15
    Conserved Domains (2) summary
    cd01671
    Location:6 → 45
    CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
    pfam12012
    Location:606 → 759
    DUF3504; Domain of unknown function (DUF3504)

  2. NM_175143.5 → NP_780352.2  transcriptional regulator QRICH1

    See identical proteins and their annotated locations for NP_780352.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant lacks an exon in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK151491, BB851544, BC120916, BF658891
    Consensus CDS
    CCDS52927.1
    UniProtKB/Swiss-Prot
    Q3UA37
    UniProtKB/TrEMBL
    A0A8C6I0G0, G3X8R5
    Related
    ENSMUSP00000107782.4, ENSMUST00000112155.9
    Conserved Domains (2) summary
    cd01671
    Location:6 → 45
    CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
    pfam12012
    Location:606 → 759
    DUF3504; Domain of unknown function (DUF3504)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    108394010..108437366
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511809.4 → XP_006511872.1  glutamine-rich protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006511872.1

    UniProtKB/TrEMBL
    A0A8C6I0G0, G3X8R5
    Conserved Domains (2) summary
    cd01671
    Location:6 → 45
    CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
    pfam12012
    Location:606 → 759
    DUF3504; Domain of unknown function (DUF3504)

  2. XM_030244560.2 → XP_030100420.1  glutamine-rich protein 1 isoform X2

    Conserved Domains (1) summary
    pfam12012
    Location:507 → 667
    DUF3504; Domain of unknown function (DUF3504)

  3. XM_006511808.4 → XP_006511871.1  glutamine-rich protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006511871.1

    UniProtKB/TrEMBL
    A0A8C6I0G0, G3X8R5
    Conserved Domains (2) summary
    cd01671
    Location:6 → 45
    CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
    pfam12012
    Location:606 → 759
    DUF3504; Domain of unknown function (DUF3504)

  4. XM_017313561.3 → XP_017169050.1  glutamine-rich protein 1 isoform X4

    Conserved Domains (2) summary
    pfam12012
    Location:256 → 416
    DUF3504; Domain of unknown function (DUF3504)
    cl14633
    Location:6 → 45
    DD; Death Domain Superfamily of protein-protein interaction domains

  5. XM_006511813.4 → XP_006511876.1  glutamine-rich protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006511876.1

    UniProtKB/TrEMBL
    A0A8C6I0G0, G3X8R5
    Conserved Domains (2) summary
    cd01671
    Location:6 → 45
    CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
    pfam12012
    Location:606 → 759
    DUF3504; Domain of unknown function (DUF3504)

  6. XM_006511812.3 → XP_006511875.1  glutamine-rich protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006511875.1

    UniProtKB/TrEMBL
    A0A8C6I0G0, G3X8R5
    Conserved Domains (2) summary
    cd01671
    Location:6 → 45
    CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
    pfam12012
    Location:606 → 759
    DUF3504; Domain of unknown function (DUF3504)

  7. XM_006511811.5 → XP_006511874.1  glutamine-rich protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006511874.1

    UniProtKB/TrEMBL
    A0A8C6I0G0, G3X8R5
    Conserved Domains (2) summary
    cd01671
    Location:6 → 45
    CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
    pfam12012
    Location:606 → 759
    DUF3504; Domain of unknown function (DUF3504)

  8. XM_006511814.3 → XP_006511877.1  glutamine-rich protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006511877.1

    UniProtKB/TrEMBL
    A0A8C6I0G0, G3X8R5
    Conserved Domains (2) summary
    cd01671
    Location:6 → 45
    CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
    pfam12012
    Location:606 → 759
    DUF3504; Domain of unknown function (DUF3504)

  9. XM_006511818.2 → XP_006511881.1  glutamine-rich protein 1 isoform X4

    See identical proteins and their annotated locations for XP_006511881.1

    Conserved Domains (2) summary
    pfam12012
    Location:256 → 416
    DUF3504; Domain of unknown function (DUF3504)
    cl14633
    Location:6 → 45
    DD; Death Domain Superfamily of protein-protein interaction domains

  10. XM_036155242.1 → XP_036011135.1  glutamine-rich protein 1 isoform X2

    Conserved Domains (1) summary
    pfam12012
    Location:507 → 667
    DUF3504; Domain of unknown function (DUF3504)

  11. XM_006511810.4 → XP_006511873.1  glutamine-rich protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006511873.1

    UniProtKB/TrEMBL
    A0A8C6I0G0, G3X8R5
    Conserved Domains (2) summary
    cd01671
    Location:6 → 45
    CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
    pfam12012
    Location:606 → 759
    DUF3504; Domain of unknown function (DUF3504)

  12. XM_036155244.1 → XP_036011137.1  glutamine-rich protein 1 isoform X4

    Conserved Domains (2) summary
    pfam12012
    Location:256 → 416
    DUF3504; Domain of unknown function (DUF3504)
    cl14633
    Location:6 → 45
    DD; Death Domain Superfamily of protein-protein interaction domains

  13. XM_017313560.3 → XP_017169049.1  glutamine-rich protein 1 isoform X2

    Conserved Domains (1) summary
    pfam12012
    Location:507 → 667
    DUF3504; Domain of unknown function (DUF3504)

  14. XM_030244561.2 → XP_030100421.1  glutamine-rich protein 1 isoform X4

    Conserved Domains (2) summary
    pfam12012
    Location:256 → 416
    DUF3504; Domain of unknown function (DUF3504)
    cl14633
    Location:6 → 45
    DD; Death Domain Superfamily of protein-protein interaction domains

  15. XM_036155243.1 → XP_036011136.1  glutamine-rich protein 1 isoform X3

    Related
    ENSMUSP00000141267.2, ENSMUST00000193258.6
    Conserved Domains (1) summary
    cd01671
    Location:6 → 45
    CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UA37.1 GenPept UniProtKB/Swiss-Prot:Q3UA37

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