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PPAN-P2RY11 PPAN-P2RY11 readthrough [ Homo sapiens (human) ]

Gene ID: 692312, updated on 4-Jul-2021

Summary

Official Symbol
PPAN-P2RY11provided by HGNC
Official Full Name
PPAN-P2RY11 readthroughprovided by HGNC
Primary source
HGNC:HGNC:33526
See related
Ensembl:ENSG00000243207
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PPAN; SSF1; BXDC3; P2Y11; Ssf-1; P2RY11
Summary
This locus represents naturally occurring read-through transcription between the adjacent PPAN and P2RY11 genes. Alternative splicing results in two transcript variants, one of which encodes a fusion protein that shares sequence identity with each individual gene product. This transcript is found to be ubiquitously expressed and is up-regulated by agents inducing granulocytic differentiation. However, its functional significance in vivo remains unclear. [provided by RefSeq, Nov 2010]
Expression
Ubiquitous expression in spleen (RPKM 8.0), lymph node (RPKM 6.7) and 25 other tissues See more
Orthologs
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Genomic context

See PPAN-P2RY11 in Genome Data Viewer
Location:
19p13.2
Exon count:
13
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (10106362..10115372)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10217038..10226048)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene complement component 3 precursor pseudogene Neighboring gene angiopoietin like 6 Neighboring gene shiftless antiviral inhibitor of ribosomal frameshifting Neighboring gene Sharpr-MPRA regulatory region 3609 Neighboring gene small nucleolar RNA, C/D box 105 Neighboring gene small nucleolar RNA, C/D box 105B Neighboring gene peter pan homolog Neighboring gene purinergic receptor P2Y11 Neighboring gene eukaryotic translation initiation factor 3 subunit G Neighboring gene DNA methyltransferase 1 Neighboring gene origin of replication in DNMT1 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 10 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic.
GeneReviews: Not available
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, PPAN-P2RY11 read through, is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with PPAN-P2RY11 is increased by RRE PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
PPAN-P2RY11 protein
Names
Brix domain-containing protein 3
P2Y purinoceptor 11
PPAN-P2RY11 readthrough transcript
Peter Pan homolog
SSF1/P2Y11 protein
Suppressor of SWI4 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040664.3NP_001035754.1  PPAN-P2RY11 protein isoform 1

    See identical proteins and their annotated locations for NP_001035754.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1), which is a fusion of the PPAN and P2RY11 products.
    Source sequence(s)
    AC020931, AJ300588
    UniProtKB/Swiss-Prot
    Q9NQ55
    UniProtKB/TrEMBL
    A0A0B4J1V8
    Related
    ENSP00000377385.4, ENST00000393796.4
    Conserved Domains (3) summary
    pfam00001
    Location:466741
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam04427
    Location:36285
    Brix; Brix domain
    cl00935
    Location:270341
    Brix; Brix domain
  2. NM_001198690.2NP_001185619.1  PPAN-P2RY11 protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The resulting isoform (2) represents a fusion of the PPAN product to a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AC020931, BC171852
    UniProtKB/TrEMBL
    A0A0A6YYI3
    Related
    ENSP00000411918.1, ENST00000428358.5
    Conserved Domains (2) summary
    pfam04427
    Location:36285
    Brix; Brix domain
    cl00935
    Location:270341
    Brix; Brix domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    10106362..10115372
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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