foxn3 forkhead box N3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: foxn3provided by ZNC
Official Full Name: forkhead box N3provided by ZNC
Primary source: ZFIN:ZDB-GENE-060512-39
See related: Ensembl:ENSDARG00000012833 AllianceGenome:ZFIN:ZDB-GENE-060512-39
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:136571
Summary: Predicted to enable DNA-binding transcription factor activity and cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in female organism and male organism. Orthologous to human FOXN3 (forkhead box N3). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 17

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	17	NC_133192.1 (17827025..18003819)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (16565185..16741175)

Chromosome 17 - NC_133192.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

liver FOXN3 and glucagon control fasting glucose.
Title: A Hepatocyte FOXN3-α Cell Glucagon Axis Regulates Fasting Glucose.
the rs8004664 risk allele drives excessive expression of FOXN3 during fasting and that FOXN3 regulates fasting blood glucose.
Title: FOXN3 Regulates Hepatic Glucose Utilization.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: forkhead box protein N3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.