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Selenot selenoprotein T [ Mus musculus (house mouse) ]

Gene ID: 69227, updated on 28-Oct-2024

Summary

Official Symbol
Selenotprovided by MGI
Official Full Name
selenoprotein Tprovided by MGI
Primary source
MGI:MGI:1916477
See related
Ensembl:ENSMUSG00000075700 AllianceGenome:MGI:1916477
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Selt; 2810407C02Rik; 5730408P04Rik
Summary
This gene encodes a selenoprotein, containing a selenocysteine (Sec) residue at the active site. Sec is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is localized in the endoplasmic reticulum. It belongs to the SelWTH family that possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif found in several redox active proteins. Studies in mice indicate a crucial role for this gene in the protection of dopaminergic neurons against oxidative stress in Parkinson's disease, and in the control of glucose homeostasis in pancreatic beta-cells. A pseudogene of this locus has been identified on chromosome 8. [provided by RefSeq, Aug 2017]
Expression
Ubiquitous expression in kidney adult (RPKM 32.3), placenta adult (RPKM 31.3) and 28 other tissues See more
Orthologs
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Genomic context

See Selenot in Genome Data Viewer
Location:
3 D; 3 28.61 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (58484057..58500965)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (58576636..58593544)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11710 Neighboring gene TSC22 domain family, member 2 Neighboring gene STARR-seq mESC enhancer starr_07749 Neighboring gene STARR-positive B cell enhancer ABC_E1618 Neighboring gene STARR-positive B cell enhancer ABC_E516 Neighboring gene STARR-positive B cell enhancer ABC_E3433 Neighboring gene stress-associated endoplasmic reticulum protein 1 Neighboring gene eukaryotic translation initiation factor 2A Neighboring gene STARR-seq mESC enhancer starr_07753 Neighboring gene STARR-seq mESC enhancer starr_07754 Neighboring gene STARR-positive B cell enhancer ABC_E9549 Neighboring gene glutamate rich 6 Neighboring gene predicted gene, 46806 Neighboring gene spermine synthase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables thioredoxin-disulfide reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables thioredoxin-disulfide reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
 
enables thioredoxin-disulfide reductase (NADPH) activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
thioredoxin reductase-like selenoprotein T
Names
thioredoxin reductase-like enzyme
NP_001035486.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040396.3NP_001035486.2  thioredoxin reductase-like selenoprotein T precursor

    See identical proteins and their annotated locations for NP_001035486.2

    Status: REVIEWED

    Source sequence(s)
    AA155383, AK013022, AK047958, BF660234, BY123391
    Consensus CDS
    CCDS38437.1
    UniProtKB/Swiss-Prot
    A2RTC6, P62342, Q8CHV4
    Related
    ENSMUSP00000103557.3, ENSMUST00000107924.3
    Conserved Domains (1) summary
    TIGR02174
    Location:41179
    CXXU_selWTH; selT/selW/selH selenoprotein domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    58484057..58500965
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_026997.1: Suppressed sequence

    Description
    NM_026997.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.