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FHIT fragile histidine triad diadenosine triphosphatase [ Bos taurus (domestic cattle) ]

Gene ID: 692183, updated on 5-Sep-2025
Official Symbol
FHITprovided by VGNC
Official Full Name
fragile histidine triad diadenosine triphosphataseprovided by VGNC
Primary source
VGNC:VGNC:28998
See related
BGD:BT13528; EnsemblRapid:ENSBTAG00070005685
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See FHIT in Genome Data Viewer
Location:
chromosome: 22
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 22 NC_037349.1 (40107030..41631056)

Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132343468 Neighboring gene uncharacterized LOC112443454 Neighboring gene uncharacterized LOC132343538 Neighboring gene uncharacterized LOC132343505 Neighboring gene uncharacterized LOC112443500 Neighboring gene uncharacterized LOC132343506

Genomic Sequence:
NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Effects of eight InDel variants in FHIT on milk traits in Xinjiang brown cattle. Ju X, et al. Anim Biotechnol, 2021 Aug. PMID 32401148
  2. Molecular analysis of the fragile histidine triad (FHIT) tumor suppressor gene in vesical tumors of cattle with chronic enzootic hematuria (CEH). Guidi E, et al. Cytogenet Genome Res, 2008. PMID 18467844
  3. Comparative genomic mapping of the bovine Fragile Histidine Triad (FHIT) tumour suppressor gene: characterization of a 2 Mb BAC contig covering the locus, complete annotation of the gene, analysis of cDNA and of physiological expression profiles. Uboldi C, et al. BMC Genomics, 2006 May 23. PMID 16719907, Free PMC Article
  4. Comparative mapping of the fragile histidine triad (FHIT) gene in cattle, river buffalo, sheep and goat by FISH and assignment to BTA22 by RH-mapping: a comparison with HSA3. Di Meo GP, et al. Anim Genet, 2005 Aug. PMID 16026356
  5. Evidence that bovine forebrain embryonic zinc finger-like gene influences immune response associated with mastitis resistance. Sugimoto M, et al. Proc Natl Acad Sci U S A, 2006 Apr 25. PMID 16611727, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Effects of eight InDel variants in FHIT on milk traits in Xinjiang brown cattle.
    Title: Effects of eight InDel variants in FHIT on milk traits in Xinjiang brown cattle.
  2. the same mRNA isoforms of FHIT were detected in bladder tumors and in healthy tissues, including a novel isoform that was found in this study, suggesting that epigenetic modifications and altered expression profiles are not a hallmark of vesical tumors
    Title: Molecular analysis of the fragile histidine triad (FHIT) tumor suppressor gene in vesical tumors of cattle with chronic enzootic hematuria (CEH).
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables bis(5'-adenosyl)-triphosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in diadenosine triphosphate catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway by p53 class mediator IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in purine nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
bis(5'-adenosyl)-triphosphatase
Names
AP3A hydrolase
AP3Aase
adenosine 5'-monophosphoramidase FHIT
adenylylsulfatase
adenylylsulfate-ammonia adenylyltransferase
diadenosine 5',5'''-P1,P3-triphosphate hydrolase
dinucleosidetriphosphatase
fragile histidine triad protein
NP_001035736.1
XP_024838827.1
XP_024838828.1
XP_024838829.1
XP_024838830.1
XP_024838831.1
XP_059735890.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040646.1 → NP_001035736.1  bis(5'-adenosyl)-triphosphatase

    See identical proteins and their annotated locations for NP_001035736.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ310181
    UniProtKB/Swiss-Prot
    A6QLK1, Q1KZG4, Q1KZS9
    UniProtKB/TrEMBL
    A0AAF6YZY4
    Conserved Domains (1) summary
    cd01275
    Location:5 → 124
    FHIT; FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into ...

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037349.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    40107030..41631056
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024983061.2 → XP_024838829.1  bis(5'-adenosyl)-triphosphatase isoform X1

    UniProtKB/Swiss-Prot
    A6QLK1, Q1KZG4, Q1KZS9
    UniProtKB/TrEMBL
    A0AAF6YZY4
    Conserved Domains (1) summary
    cd01275
    Location:5 → 124
    FHIT; FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into ...

  2. XM_024983062.2 → XP_024838830.1  bis(5'-adenosyl)-triphosphatase isoform X1

    UniProtKB/Swiss-Prot
    A6QLK1, Q1KZG4, Q1KZS9
    UniProtKB/TrEMBL
    A0AAF6YZY4
    Conserved Domains (1) summary
    cd01275
    Location:5 → 124
    FHIT; FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into ...

  3. XM_024983060.2 → XP_024838828.1  bis(5'-adenosyl)-triphosphatase isoform X1

    UniProtKB/Swiss-Prot
    A6QLK1, Q1KZG4, Q1KZS9
    UniProtKB/TrEMBL
    A0AAF6YZY4
    Conserved Domains (1) summary
    cd01275
    Location:5 → 124
    FHIT; FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into ...

  4. XM_024983059.2 → XP_024838827.1  bis(5'-adenosyl)-triphosphatase isoform X1

    UniProtKB/Swiss-Prot
    A6QLK1, Q1KZG4, Q1KZS9
    UniProtKB/TrEMBL
    A0AAF6YZY4
    Conserved Domains (1) summary
    cd01275
    Location:5 → 124
    FHIT; FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into ...

  5. XM_024983063.2 → XP_024838831.1  bis(5'-adenosyl)-triphosphatase isoform X1

    UniProtKB/Swiss-Prot
    A6QLK1, Q1KZG4, Q1KZS9
    UniProtKB/TrEMBL
    A0AAF6YZY4
    Conserved Domains (1) summary
    cd01275
    Location:5 → 124
    FHIT; FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into ...

  6. XM_059879907.1 → XP_059735890.1  bis(5'-adenosyl)-triphosphatase isoform X1

    UniProtKB/Swiss-Prot
    A6QLK1, Q1KZG4, Q1KZS9
    UniProtKB/TrEMBL
    A0AAF6YZY4
    Related
    ENSBTAP00070007462.1, ENSBTAT00070013034.1

RNA

  1. XR_009492299.1 RNA Sequence

  2. XR_009492298.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q1KZG4.1 GenPept UniProtKB/Swiss-Prot:Q1KZG4

Gene LinkOut

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