Format

Send to:

Choose Destination

TCEA3 transcription elongation factor A3 [ Homo sapiens (human) ]

Gene ID: 6920, updated on 13-Mar-2020

Summary

Official Symbol
TCEA3provided by HGNC
Official Full Name
transcription elongation factor A3provided by HGNC
Primary source
HGNC:HGNC:11615
See related
Ensembl:ENSG00000204219 MIM:604128
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TFIIS; TFIIS.H
Expression
Ubiquitous expression in colon (RPKM 19.3), ovary (RPKM 18.5) and 23 other tissues See more
Orthologs

Genomic context

See TCEA3 in Genome Data Viewer
Location:
1p36.12
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (23380909..23424776, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (23707555..23751269, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene MIR1 retrotransposon enhancer-blocking element Neighboring gene zinc finger protein 436 Neighboring gene ZNF436 antisense RNA 1 Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 Neighboring gene uncharacterized LOC101928163 Neighboring gene E2F transcription factor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat TFIIS synergizes with HIV-1 Tat during transactivation of the HIV-1 LTR promoter PubMed
tat HIV-1 Tat directly interacts with SII (TFIIS) as demonstrated by Tat-affinity column purification PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transcription elongation factor A protein 3
Names
rhabdomyosarcoma antigen MU-RMS-40.22
transcription elongation factor A (SII), 3
transcription elongation factor S-II protein 3
transcription elongation factor TFIIS.h

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003196.3NP_003187.1  transcription elongation factor A protein 3

    See identical proteins and their annotated locations for NP_003187.1

    Status: VALIDATED

    Source sequence(s)
    AA873235, AK290272, AK300707, AL109936, BE880226, BI835458, BQ003897, CU449151, HY070786
    Consensus CDS
    CCDS44086.1
    UniProtKB/Swiss-Prot
    O75764
    UniProtKB/TrEMBL
    B4DUM4
    Related
    ENSP00000406293.2, ENST00000450454.7
    Conserved Domains (1) summary
    cl02637
    Location:5348
    TFIIS_M; Transcription factor S-II (TFIIS), central domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    23380909..23424776 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449399.1XP_024305167.1  transcription elongation factor A protein 3 isoform X8

    Conserved Domains (1) summary
    cl02637
    Location:1311
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
  2. XM_011542053.3XP_011540355.1  transcription elongation factor A protein 3 isoform X4

    Conserved Domains (1) summary
    cl02637
    Location:5346
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
  3. XM_017002204.2XP_016857693.1  transcription elongation factor A protein 3 isoform X7

  4. XM_017002201.1XP_016857690.1  transcription elongation factor A protein 3 isoform X2

  5. XM_017002203.1XP_016857692.1  transcription elongation factor A protein 3 isoform X5

  6. XM_006710864.2XP_006710927.1  transcription elongation factor A protein 3 isoform X6

    Related
    ENSP00000474530.2, ENST00000476978.2
    Conserved Domains (4) summary
    cd00183
    Location:480
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
    cd13749
    Location:301346
    Zn-ribbon_TFIIS; domain III/zinc ribbon domain of Transcription Factor IIS
    TIGR01385
    Location:5346
    TFSII; transcription elongation factor S-II
    pfam07500
    Location:185292
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
  7. XM_017002200.2XP_016857689.1  transcription elongation factor A protein 3 isoform X1

  8. XM_017002202.2XP_016857691.1  transcription elongation factor A protein 3 isoform X3

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_014040926.1 Reference GRCh38.p13 PATCHES

    Range
    150888..194727 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center