Format

Send to:

Choose Destination

TCEA2 transcription elongation factor A2 [ Homo sapiens (human) ]

Gene ID: 6919, updated on 6-Jan-2019

Summary

Official Symbol
TCEA2provided by HGNC
Official Full Name
transcription elongation factor A2provided by HGNC
Primary source
HGNC:HGNC:11614
See related
Ensembl:ENSG00000171703 MIM:604784
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TFIIS
Summary
The protein encoded by this gene is found in the nucleus, where it functions as an SII class transcription elongation factor. Elongation factors in this class are responsible for releasing RNA polymerase II ternary complexes from transcriptional arrest at template-encoded arresting sites. The encoded protein has been shown to interact with general transcription factor IIB, a basal transcription factor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 9.5), brain (RPKM 6.6) and 25 other tissues See more
Orthologs

Genomic context

See TCEA2 in Genome Data Viewer
Location:
20q13.33
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (64042350..64072347)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (62688439..62703700)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene pre-mRNA processing factor 6 Neighboring gene chromosome 20 open reading frame 204 Neighboring gene SOX18 promoter region Neighboring gene SRY-box 18 Neighboring gene regulator of G protein signaling 19 Neighboring gene microRNA 6813 Neighboring gene LKAAEAR motif containing 1 Neighboring gene opioid related nociceptin receptor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic Variants Associated with Serum Thyroid Stimulating Hormone (TSH) Levels in European Americans and African Americans from the eMERGE Network.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat TFIIS synergizes with HIV-1 Tat during transactivation of the HIV-1 LTR promoter PubMed
tat HIV-1 Tat directly interacts with SII (TFIIS) as demonstrated by Tat-affinity column purification PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA-templated transcription, elongation NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of DNA-templated transcription, elongation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
transcription elongation factor complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
transcription elongation factor A protein 2
Names
testis-specific S-II
transcription elongation factor A (SII), 2
transcription elongation factor S-II protein 2
transcription elongation factor TFIIS.1
transcription elongation factor TFIIS.l

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003195.6NP_003186.1  transcription elongation factor A protein 2 isoform a

    See identical proteins and their annotated locations for NP_003186.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    BC018896, CA440059, DB482075
    Consensus CDS
    CCDS13553.1
    UniProtKB/Swiss-Prot
    Q15560
    UniProtKB/TrEMBL
    Q6IB64
    Related
    ENSP00000343515.5, ENST00000343484.9
    Conserved Domains (1) summary
    cl02637
    Location:6299
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
  2. NM_198723.2NP_942016.1  transcription elongation factor A protein 2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    BC018896, BI756937, CA440059, CB961240
    Consensus CDS
    CCDS13554.1
    UniProtKB/Swiss-Prot
    Q15560
    Related
    ENSP00000354552.2, ENST00000361317.6
    Conserved Domains (1) summary
    cl02637
    Location:1272
    TFIIS_M; Transcription factor S-II (TFIIS), central domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

    Range
    64042350..64072347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529022.1XP_011527324.1  transcription elongation factor A protein 2 isoform X2

    See identical proteins and their annotated locations for XP_011527324.1

    Conserved Domains (1) summary
    cl02637
    Location:1270
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
  2. XM_024451978.1XP_024307746.1  transcription elongation factor A protein 2 isoform X2

    Conserved Domains (1) summary
    cl02637
    Location:1270
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
  3. XM_024451984.1XP_024307752.1  transcription elongation factor A protein 2 isoform X2

    Conserved Domains (1) summary
    cl02637
    Location:1270
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
  4. XM_024451975.1XP_024307743.1  transcription elongation factor A protein 2 isoform X2

    Conserved Domains (1) summary
    cl02637
    Location:1270
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
  5. XM_024451987.1XP_024307755.1  transcription elongation factor A protein 2 isoform X3

    Conserved Domains (1) summary
    cl02637
    Location:1272
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
  6. XM_024451976.1XP_024307744.1  transcription elongation factor A protein 2 isoform X2

    Conserved Domains (1) summary
    cl02637
    Location:1270
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
  7. XM_024451979.1XP_024307747.1  transcription elongation factor A protein 2 isoform X2

    Conserved Domains (1) summary
    cl02637
    Location:1270
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
  8. XM_024451981.1XP_024307749.1  transcription elongation factor A protein 2 isoform X2

    Conserved Domains (1) summary
    cl02637
    Location:1270
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
  9. XM_024451977.1XP_024307745.1  transcription elongation factor A protein 2 isoform X2

    Conserved Domains (1) summary
    cl02637
    Location:1270
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
  10. XM_024451980.1XP_024307748.1  transcription elongation factor A protein 2 isoform X2

    Conserved Domains (1) summary
    cl02637
    Location:1270
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
  11. XM_024451982.1XP_024307750.1  transcription elongation factor A protein 2 isoform X2

    Conserved Domains (1) summary
    cl02637
    Location:1270
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
  12. XM_024451983.1XP_024307751.1  transcription elongation factor A protein 2 isoform X2

    Conserved Domains (1) summary
    cl02637
    Location:1270
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
  13. XM_005260229.4XP_005260286.1  transcription elongation factor A protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005260286.1

    Conserved Domains (4) summary
    cd00183
    Location:581
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
    cd13749
    Location:252297
    Zn-ribbon_TFIIS; domain III/zinc ribbon domain of Transcription Factor IIS
    TIGR01385
    Location:6297
    TFSII; transcription elongation factor S-II
    pfam07500
    Location:136243
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
  14. XM_024451988.1XP_024307756.1  transcription elongation factor A protein 2 isoform X3

    Related
    ENSP00000339432.4, ENST00000339217.8
    Conserved Domains (1) summary
    cl02637
    Location:1272
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
  15. XM_024451985.1XP_024307753.1  transcription elongation factor A protein 2 isoform X2

    Related
    ENSP00000407085.1, ENST00000440819.5
    Conserved Domains (1) summary
    cl02637
    Location:1270
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
  16. XM_024451986.1XP_024307754.1  transcription elongation factor A protein 2 isoform X2

    Related
    ENSP00000416026.1, ENST00000458442.1
    Conserved Domains (1) summary
    cl02637
    Location:1270
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
  17. XM_024451989.1XP_024307757.1  transcription elongation factor A protein 2 isoform X3

    Conserved Domains (1) summary
    cl02637
    Location:1272
    TFIIS_M; Transcription factor S-II (TFIIS), central domain

RNA

  1. XR_002958521.1 RNA Sequence

Support Center