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Stimate STIM activating enhancer [ Mus musculus (house mouse) ]

Gene ID: 69179, updated on 30-Apr-2024

Summary

Official Symbol
Stimateprovided by MGI
Official Full Name
STIM activating enhancerprovided by MGI
Primary source
MGI:MGI:1921500
See related
Ensembl:ENSMUSG00000006526 AllianceGenome:MGI:1921500
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmem110; 1810038N08Rik; 2310014H19Rik
Summary
Predicted to enable calcium channel regulator activity. Predicted to be involved in activation of store-operated calcium channel activity and calcium-mediated signaling using intracellular calcium source. Predicted to be located in endoplasmic reticulum membrane and endoplasmic reticulum-plasma membrane contact site. Predicted to be active in cortical endoplasmic reticulum and membrane. Is expressed in lung; spleen; stomach; and testis. Orthologous to several human genes including STIMATE (STIM activating enhancer). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 15.9), ovary adult (RPKM 12.4) and 28 other tissues See more
Orthologs
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Genomic context

See Stimate in Genome Data Viewer
Location:
14 B; 14 19.09 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (30547533..30599167)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (30825575..30877210)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene Scm-like with four mbt domains 1 Neighboring gene RIKEN cDNA 1700087M22 gene Neighboring gene transformer 2 beta homolog pseudogene Neighboring gene musculoskeletal, embryonic nuclear protein 1 Neighboring gene inter alpha-trypsin inhibitor, heavy chain 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in activation of store-operated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cortical endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cortical endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum-plasma membrane contact site ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
store-operated calcium entry regulator STIMATE
Names
STIM-activating enhancer encoded by TMEM110
transmembrane protein 110

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028839.4NP_083115.3  store-operated calcium entry regulator STIMATE

    See identical proteins and their annotated locations for NP_083115.3

    Status: VALIDATED

    Source sequence(s)
    AK009341, BE944885, CJ180452, CT025528
    Consensus CDS
    CCDS26899.1
    UniProtKB/Swiss-Prot
    Q3U2J0, Q3UF25, Q8C691, Q8R3U0, Q9D7D4, Q9D8S1
    Related
    ENSMUSP00000006701.6, ENSMUST00000006701.8
    Conserved Domains (1) summary
    pfam12400
    Location:100219
    STIMATE; STIMATE family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    30547533..30599167
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247992.2XP_030103852.1  store-operated calcium entry regulator STIMATE isoform X1

    Conserved Domains (1) summary
    pfam12400
    Location:58177
    STIMATE; STIMATE family
  2. XM_036158839.1XP_036014732.1  store-operated calcium entry regulator STIMATE isoform X2

    Conserved Domains (1) summary
    pfam12400
    Location:685
    STIMATE; STIMATE family