Format

Send to:

Choose Destination

TCEA1 transcription elongation factor A1 [ Homo sapiens (human) ]

Gene ID: 6917, updated on 5-Jul-2020

Summary

Official Symbol
TCEA1provided by HGNC
Official Full Name
transcription elongation factor A1provided by HGNC
Primary source
HGNC:HGNC:11612
See related
Ensembl:ENSG00000187735 MIM:601425
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SII; TCEA; TF2S; GTF2S; TFIIS
Expression
Ubiquitous expression in thyroid (RPKM 66.3), lymph node (RPKM 39.6) and 25 other tissues See more
Orthologs

Genomic context

See TCEA1 in Genome Data Viewer
Location:
8q11.23
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (53966556..54022448, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (54879116..54935008, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene regulator of G protein signaling 20 Neighboring gene RNA, U6 small nuclear 1331, pseudogene Neighboring gene Sharpr-MPRA regulatory region 792/14152 Neighboring gene ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) pseudogene Neighboring gene uncharacterized LOC105375839 Neighboring gene lysophospholipase 1 Neighboring gene teratocarcinoma-derived growth factor 1 pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat TFIIS synergizes with HIV-1 Tat during transactivation of the HIV-1 LTR promoter PubMed
tat HIV-1 Tat directly interacts with SII (TFIIS) as demonstrated by Tat-affinity column purification PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
positive regulation of exoribonuclease activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
transcription elongation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
transcription-coupled nucleotide-excision repair TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
transcription factor TFIID complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transcription elongation factor A protein 1
Names
epididymis secretory sperm binding protein
transcription elongation factor A (SII), 1
transcription elongation factor S-II protein 1
transcription elongation factor TFIIS.o
transcription factor IIS

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006756.4NP_006747.1  transcription elongation factor A protein 1 isoform 1

    See identical proteins and their annotated locations for NP_006747.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BQ016366, DA021678, DB091231, X62585
    Consensus CDS
    CCDS47858.1
    UniProtKB/Swiss-Prot
    P23193
    Related
    ENSP00000428426.2, ENST00000521604.7
    Conserved Domains (1) summary
    cl02637
    Location:4301
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
  2. NM_201437.3NP_958845.1  transcription elongation factor A protein 1 isoform 2

    See identical proteins and their annotated locations for NP_958845.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AK297957, BC072460, BQ016366, DA021678, DB091231, X62585
    Consensus CDS
    CCDS47857.1
    UniProtKB/Swiss-Prot
    P23193
    UniProtKB/TrEMBL
    B7Z4W0
    Related
    ENSP00000395483.2, ENST00000396401.7
    Conserved Domains (1) summary
    cl02637
    Location:4280
    TFIIS_M; Transcription factor S-II (TFIIS), central domain

RNA

  1. NR_109901.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC072460, BQ016366, BX538034, DA021678, DB091231, X62585
    Related
    ENST00000521086.6
  2. NR_109902.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks several internal exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AK297729, BQ016366, DA021678, DB091231, X62585

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    53966556..54022448 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006716467.1XP_006716530.1  transcription elongation factor A protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006716530.1

    Conserved Domains (1) summary
    cl02637
    Location:1254
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
  2. XM_011517578.1XP_011515880.1  transcription elongation factor A protein 1 isoform X1

    Conserved Domains (1) summary
    cl02637
    Location:1266
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
Support Center