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Myh2 myosin heavy chain 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 691644, updated on 13-Aug-2019

Summary

Official Symbol
Myh2provided by RGD
Official Full Name
myosin heavy chain 2provided by RGD
Primary source
RGD:620354
See related
Ensembl:ENSRNOG00000049695
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Myh1; Myh2a; MyHC-2A; MyHC-IIA
Summary
mouse homolog is a heavy chain skeletal muscle myosin [RGD, Feb 2006]
Expression
Restricted expression toward (RPKM 24451.0) See more
Orthologs

Genomic context

See Myh2 in Genome Data Viewer
Location:
10q24
Exon count:
39
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (53711895..53738164)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (53465051..53491320)

Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103693349 Neighboring gene uncharacterized LOC103693350 Neighboring gene uncharacterized LOC102555216 Neighboring gene myosin heavy chain 1 Neighboring gene myosin heavy chain 4

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Tight junction, organism-specific biosystem (from KEGG)
    Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
  • Tight junction, conserved biosystem (from KEGG)
    Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
actin filament binding IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
motor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
actin-mediated cell contraction ISO
Inferred from Sequence Orthology
more info
PubMed 
muscle contraction ISO
Inferred from Sequence Orthology
more info
PubMed 
myosin filament assembly TAS
Traceable Author Statement
more info
PubMed 
plasma membrane repair ISO
Inferred from Sequence Orthology
more info
PubMed 
response to activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
A band ISO
Inferred from Sequence Orthology
more info
PubMed 
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
PubMed 
actomyosin contractile ring ISO
Inferred from Sequence Orthology
more info
PubMed 
cell-cell junction ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular_component ND
No biological Data available
more info
 
myofibril ISO
Inferred from Sequence Orthology
more info
PubMed 
myosin complex IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
myosin heavy chain IIa
Names
2A myosin heavy chain
myosin heavy chain type IIx
myosin, heavy chain 2, skeletal muscle, adult
myosin, heavy polypeptide 2, skeletal muscle, adult

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135157.1NP_001128629.1  myosin heavy chain IIa

    See identical proteins and their annotated locations for NP_001128629.1

    Status: VALIDATED

    Source sequence(s)
    AAHX01064481
    Related
    ENSRNOP00000004236.6, ENSRNOT00000004236.6
    Conserved Domains (7) summary
    cl22853
    Location:100773
    Motor_domain; Myosin and Kinesin motor domain
    pfam00063
    Location:88773
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:8531930
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:3673
    Myosin_N; Myosin N-terminal SH3-like domain
    cl00459
    Location:13021414
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    cl19219
    Location:16731770
    DUF342; Protein of unknown function (DUF342)
    cl23720
    Location:9681101
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

    Range
    53711895..53738164
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000078.1 Alternate Rn_Celera

    Range
    51039592..51066088
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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