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Pkd1l2 polycystin 1 like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 691069, updated on 4-Jan-2025

Summary

Official Symbol
Pkd1l2provided by RGD
Official Full Name
polycystin 1 like 2provided by RGD
Primary source
RGD:1588631
See related
EnsemblRapid:ENSRNOG00000045626 AllianceGenome:RGD:1588631
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable calcium channel activity. Predicted to be involved in detection of mechanical stimulus. Predicted to be active in membrane. Orthologous to human PKD1L2 (polycystin 1 like 2 (gene/pseudogene)). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Testes (RPKM 6.4), Liver (RPKM 2.8) and 3 other tissues See more
Orthologs
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Genomic context

See Pkd1l2 in Genome Data Viewer
Location:
19q12
Exon count:
43
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (61958351..62045324, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (45049713..45136503, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (49535122..49624291, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 16 open reading frame 46 Neighboring gene glycine cleavage system protein H Neighboring gene uncharacterized LOC134483653 Neighboring gene beta-carotene oxygenase 1 Neighboring gene small ribosomal subunit protein eS24-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in detection of mechanical stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
polycystin-1-like protein 2
Names
polycystic kidney disease 1-like 2
polycystic kidney disease protein 1-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    61958351..62045324 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039098121.2XP_038954049.1  polycystin-1-like protein 2

    UniProtKB/TrEMBL
    M0R5G5
    Related
    ENSRNOP00000064630.3, ENSRNOT00000071130.4
    Conserved Domains (6) summary
    cd00037
    Location:70186
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cd01752
    Location:14181537
    PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...
    pfam02010
    Location:697894
    REJ; REJ domain
    pfam01825
    Location:13081347
    GPS; GPCR proteolysis site, GPS, motif
    pfam02140
    Location:201283
    Gal_Lectin; Galactose binding lectin domain
    pfam08016
    Location:20132433
    PKD_channel; Polycystin cation channel