Vps26b VPS26 retromer complex component B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vps26bprovided by MGI
Official Full Name: VPS26 retromer complex component Bprovided by MGI
Primary source: MGI:MGI:1917656
See related: Ensembl:ENSMUSG00000031988 AllianceGenome:MGI:1917656
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1810012I05Rik; 2310075A12Rik
Summary: Involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane and retrograde transport, endosome to Golgi. Acts upstream of or within cellular response to type II interferon. Located in early endosome; late endosome; and phagocytic vesicle. Part of retromer complex. Is active in glutamatergic synapse; postsynaptic early endosome; and postsynaptic recycling endosome. Is expressed in several structures, including central nervous system; dorsal root ganglion; male reproductive system; sensory organ; and urinary system. Orthologous to human VPS26B (VPS26 retromer complex component B). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Ubiquitous expression in CNS E18 (RPKM 18.6), ovary adult (RPKM 18.4) and 28 other tissues See more
Orthologs: all
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Genomic context

Location:: 9 A4; 9 12.07 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (26915798..26941390, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (27004502..27030094, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that mouse Vps26b-Vps29-Vps35 retromer complex is implicated in the transport of sortilin from endosomes to the trans-Golgi network.
Title: Implication of mouse Vps26b-Vps29-Vps35 retromer complex in sortilin trafficking.
both Vps26A and Vps26B are incorporated into retromer complexes through binding of Vps35 to a highly conserved surface patch within the C-terminal subdomain
Title: Structure of Vps26B and mapping of its interaction with the retromer protein complex.
Vps26B was found in the cytoplasm with low levels at the plasma membrane, while Vps26A was predominantly associated with endosomal membranes
Title: A novel mammalian retromer component, Vps26B.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retrograde transport, endosome to Golgi	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde transport, endosome to Golgi	IEA Inferred from Electronic Annotation more info
involved_in retrograde transport, endosome to Golgi	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	EXP Inferred from Experiment more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	IEA Inferred from Electronic Annotation more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome	IEA Inferred from Electronic Annotation more info
located_in membrane	EXP Inferred from Experiment more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in phagocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic early endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic early endosome	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in postsynaptic recycling endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic recycling endosome	IMP Inferred from Mutant Phenotype more info	PubMed
part_of retromer complex	IDA Inferred from Direct Assay more info	PubMed
part_of retromer complex	IEA Inferred from Electronic Annotation more info
part_of retromer, cargo-selective complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: vacuolar protein sorting-associated protein 26B

Names: vacuolar protein sorting 26 homolog B; vesicle protein sorting 26B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.