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TBP TATA-box binding protein [ Homo sapiens (human) ]

Gene ID: 6908, updated on 12-Aug-2018

Summary

Official Symbol
TBPprovided by HGNC
Official Full Name
TATA-box binding proteinprovided by HGNC
Primary source
HGNC:HGNC:11588
See related
Ensembl:ENSG00000112592 MIM:600075; Vega:OTTHUMG00000016084
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HDL4; GTF2D; SCA17; TFIID; GTF2D1
Summary
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 25-42, and expansion of the number of repeats to 45-66 increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2016]
Expression
Broad expression in testis (RPKM 21.7), lymph node (RPKM 7.6) and 24 other tissues See more
Orthologs

Genomic context

See TBP in Genome Data Viewer
Location:
6q27
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (170554333..170572870)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (170863384..170881958)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378157 Neighboring gene proteasome subunit beta 1 Neighboring gene TATA-box binding protein repeat instability region Neighboring gene programmed cell death 2 Neighboring gene putative hydro-lyase KRH_21160

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The transcription factors and kinases c-Jun, JNK, MEK, p38 MAPK, STAT-3, JAK-1, TFII D, TFII F, eIF-4E, and RNA polymerase II are induced by HIV-1 gp120 PubMed
Tat tat Recruitment of TBP to the HIV-1 LTR promoter is a limiting step for HIV-1 Tat transactivation, however interaction of Tat with TBP/TFIID occurs after this recruitment PubMed
tat TBP is required for HIV-1 Tat-mediated transactivation of the HIV-1 LTR promoter PubMed
tat TBP interacts with HIV-1 Tat as part of the HIV-1 transcription preinitiation complex (PIC) and is necessary for Tat association with the PIC PubMed
tat Inhibition of HIV-1 Tat by p53 is mediated through the Sp1 and TATA box of the HIV-1 LTR, suggesting p53 interferes with the interaction between Tat and TBP during LTR transactivation PubMed
tat Interaction of TBP/TFIID with the HIV-1 LTR, and therefore presumably HIV-1 Tat, is primarily dependent on the LTR TATA element and may also be stabilized or regulated by flanking E box motifs and basic helix-loop-helix proteins such as AP-4 and E47 PubMed
tat HIV-1 Tat competes for Dr1 interaction with TBP PubMed
tat Binding of HIV-1 Tat to the TBP subunit of TFIID stabilizes the interaction of TFIID with TFIIA PubMed
tat HIV-1 Tat interacts with the RNA polymerase II holoenzyme complex that supports Tat-mediated transactivation of the HIV-1 LTR in vitro upon addition of TBP and TFIIB PubMed
tat TBP synergizes with HIV-1 Tat during Tat-mediated transactivation of the HIV-1 LTR promoter PubMed
tat Binding of HIV-1 Tat to TBP has been mapped to the cysteine rich and core domains (amino acids 20-50) of Tat and the H1 alpha helical and S2 domains (amino acids 163-220) of TBP PubMed
tat HIV-1 Tat directly interacts with TBP as demonstrated by Tat-affinity column purification PubMed
tat HIV-1 Tat binds directly to the basal transcription factor TFIID through the TBP subunit of TFIID PubMed
tat Binding of HIV-1 Tat to p300 induces a conformational change in the CBP/p300 complex such that it can acquire and bind better to basal transcription factors such as TBP, indicating Tat helps CBP/p300 recruit new partners to the transcription machinery PubMed
Vpr vpr HIV-1 Vpr (amino acids 1-35) binds to TFIID, an interaction that is associated with the ability of Vpr to stimulate transcription through the glucocorticoid receptor pathway PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117320, MGC126054, MGC126055

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
RNA polymerase II core promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II general transcription initiation factor activity IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II repressing transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase III general transcription initiation factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
RNA polymerase III regulatory region DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
TFIIB-class transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
aryl hydrocarbon receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
core promoter binding IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
repressing transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
RNA polymerase II transcriptional preinitiation complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase III transcriptional preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of gene expression, epigenetic TAS
Traceable Author Statement
more info
 
positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase III IEA
Inferred from Electronic Annotation
more info
 
snRNA transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
termination of RNA polymerase I transcription TAS
Traceable Author Statement
more info
 
transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription by RNA polymerase II IC
Inferred by Curator
more info
PubMed 
transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
transcription by RNA polymerase III IDA
Inferred from Direct Assay
more info
PubMed 
transcription by RNA polymerase III IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription initiation from RNA polymerase I promoter TAS
Traceable Author Statement
more info
 
transcription initiation from RNA polymerase II promoter IC
Inferred by Curator
more info
PubMed 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
female pronucleus IEA
Inferred from Electronic Annotation
more info
 
male pronucleus IEA
Inferred from Electronic Annotation
more info
 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear euchromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription factor TFIIA complex IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor TFIID complex IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor TFIIIB complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcriptional preinitiation complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
TATA-box-binding protein
Names
TATA sequence-binding protein
TATA-box binding protein N-terminal domain
TATA-box factor
transcription initiation factor TFIID TBP subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008165.1 RefSeqGene

    Range
    4951..23488
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001172085.1NP_001165556.1  TATA-box-binding protein isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK304648, AL031259, BM720195, CA422572
    Consensus CDS
    CCDS55077.1
    UniProtKB/Swiss-Prot
    P20226
    Related
    ENSP00000442132.1, ENST00000540980.5
    Conserved Domains (2) summary
    PLN00062
    Location:142318
    PLN00062; TATA-box-binding protein; Provisional
    cd04516
    Location:142315
    TBP_eukaryotes; eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation ...
  2. NM_003194.4NP_003185.1  TATA-box-binding protein isoform 1

    See identical proteins and their annotated locations for NP_003185.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL031259, BC109053, BM720195, CA422572
    Consensus CDS
    CCDS5315.1
    UniProtKB/Swiss-Prot
    P20226
    UniProtKB/TrEMBL
    Q32MN7
    Related
    ENSP00000375942.2, ENST00000392092.6
    Conserved Domains (2) summary
    PLN00062
    Location:162338
    PLN00062; TATA-box-binding protein; Provisional
    cd04516
    Location:162335
    TBP_eukaryotes; eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    170554333..170572870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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