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Chac1 ChaC, cation transport regulator 1 [ Mus musculus (house mouse) ]

Gene ID: 69065, updated on 26-Mar-2023

Summary

Official Symbol
Chac1provided by MGI
Official Full Name
ChaC, cation transport regulator 1provided by MGI
Primary source
MGI:MGI:1916315
See related
Ensembl:ENSMUSG00000027313 AllianceGenome:MGI:1916315
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810008K03Rik
Summary
Enables Notch binding activity. Involved in neurogenesis. Located in trans-Golgi network. Is expressed in embryo. Orthologous to human CHAC1 (ChaC glutathione specific gamma-glutamylcyclotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in stomach adult (RPKM 8.7), mammary gland adult (RPKM 8.4) and 23 other tissues See more
Orthologs
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Genomic context

See Chac1 in Genome Data Viewer
Location:
2; 2 E5
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (119181723..119184807)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (119351242..119354326)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 52558 Neighboring gene predicted gene 14207 Neighboring gene delta like canonical Notch ligand 4 Neighboring gene INO80 complex subunit Neighboring gene predicted gene, 33412 Neighboring gene cyclin-dependent kinase 12 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Notch binding IDA
Inferred from Direct Assay
more info
PubMed 
enables gamma-glutamylcyclotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glutathione specific gamma-glutamylcyclotransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
glutathione-specific gamma-glutamylcyclotransferase 1
Names
ChaC, cation transport regulator-like 1
blocks Notch protein
botch
cation transport regulator-like protein 1
gamma-GCG 1
NP_081205.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026929.4NP_081205.1  glutathione-specific gamma-glutamylcyclotransferase 1

    See identical proteins and their annotated locations for NP_081205.1

    Status: VALIDATED

    Source sequence(s)
    AK007378, BI872476, BM899230
    Consensus CDS
    CCDS16601.1
    UniProtKB/Swiss-Prot
    Q8R3J5, Q9D944
    UniProtKB/TrEMBL
    A0A6P5P7K6
    Related
    ENSMUSP00000028780.4, ENSMUST00000028780.4
    Conserved Domains (1) summary
    pfam04752
    Location:34209
    ChaC; ChaC-like protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    119181723..119184807
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)