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Pnlip pancreatic lipase [ Mus musculus (house mouse) ]

Gene ID: 69060, updated on 24-Jul-2018

Summary

Official Symbol
Pnlipprovided by MGI
Official Full Name
pancreatic lipaseprovided by MGI
Primary source
MGI:MGI:97722
See related
Ensembl:ENSMUSG00000046008
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PL; PTL; 1810007A24Rik
Expression
Biased expression in small intestine adult (RPKM 823.6), spleen adult (RPKM 764.6) and 2 other tissues See more
Orthologs

Genomic context

See Pnlip in Genome Data Viewer
Location:
19 D2; 19 54.46 cM
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (58670365..58681788)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (58744855..58756278)

Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 172 Neighboring gene RIKEN cDNA 1810007D17 gene Neighboring gene RIKEN cDNA 1810035K13 gene Neighboring gene RIKEN cDNA 1810018F18 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Homology

Clone Names

  • MGC74173

Gene Ontology Provided by MGI

Function Evidence Code Pubs
carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
lipase activity ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
triglyceride lipase activity IDA
Inferred from Direct Assay
more info
PubMed 
triglyceride lipase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
intestinal cholesterol absorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of triglyceride lipase activity ISO
Inferred from Sequence Orthology
more info
 
post-embryonic development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
pancreatic triacylglycerol lipase
Names
pancreatic triglyceride lipase
NP_081201.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026925.4NP_081201.2  pancreatic triacylglycerol lipase precursor

    See identical proteins and their annotated locations for NP_081201.2

    Status: VALIDATED

    Source sequence(s)
    AV049089, BC061061
    Consensus CDS
    CCDS29930.1
    UniProtKB/Swiss-Prot
    Q6P8U6
    Related
    ENSMUSP00000056377.7, ENSMUST00000057270.7
    Conserved Domains (3) summary
    cd00707
    Location:51348
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    cd01759
    Location:355465
    PLAT_PL; PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of ...
    pfam00151
    Location:18352
    Lipase; Lipase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

    Range
    58670365..58681788
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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