Scai suppressor of cancer cell invasion [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Scaiprovided by RGD
Official Full Name: suppressor of cancer cell invasionprovided by RGD
Primary source: RGD:1594720
See related: Ensembl:ENSRNOG00000025278 AllianceGenome:RGD:1594720
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of Rho protein signal transduction and negative regulation of cell migration. Predicted to be located in cytoplasm; nuclear membrane; and nucleoplasm. Predicted to be active in nucleus. Orthologous to human SCAI (suppressor of cancer cell invasion). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Brain (RPKM 164.7), Thymus (RPKM 130.7) and 9 other tissues See more
Orthologs: all
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Genomic context

Location:: 3q12

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (43222983..43335056, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (22813283..22925337, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (23357586..23474218, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Differential localization and roles of splice variants of rat suppressor of cancer cell invasion (SCAI) in neuronal cells.
Title: Differential localization and roles of splice variants of rat suppressor of cancer cell invasion (SCAI) in neuronal cells.
SCAI is a novel transcriptional cofactor that regulates epithelial-to-mesenchymal transition and renal fibrosis.
Title: Characterization and role of SCAI during renal fibrosis and epithelial-to-mesenchymal transition.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D3Rat276 (e-PCR), detects polymorphism
- UniSTS:227661

MARC_10305-10306:998934185:1 (e-PCR)
- UniSTS:267106

Scai (e-PCR), detects polymorphism
- UniSTS:527534

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Rho protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein SCAI

Names: rCG37693-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.