Atp2c2 ATPase, Ca++ transporting, type 2C, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Atp2c2provided by MGI
Official Full Name: ATPase, Ca++ transporting, type 2C, member 2provided by MGI
Primary source: MGI:MGI:1916297
See related: Ensembl:ENSMUSG00000034112 AllianceGenome:MGI:1916297
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Spca2; mKIAA0703; 1810010G06Rik
Summary: Predicted to enable P-type calcium transporter activity and P-type manganese transporter activity. Acts upstream of or within mammary gland epithelium development; positive regulation of calcium ion import; and protein localization to plasma membrane. Located in several cellular components, including cytoplasmic side of plasma membrane; perinuclear region of cytoplasm; and trans-Golgi network membrane. Orthologous to human ATP2C2 (ATPase secretory pathway Ca2+ transporting 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in colon adult (RPKM 32.1), large intestine adult (RPKM 4.2) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8; 8 E1

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (120426748..120484457)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (119700009..119757718)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The goal of this study was to delineate the gene structure and regulation of a novel pancreas-specific isoform for Secretory Pathway Ca(2+) ATPase 2 (termed SPCA2C), which is encoded from the Atp2c2 gene.
Title: Atp2c2 Is Transcribed From a Unique Transcriptional Start Site in Mouse Pancreatic Acinar Cells.
SPCA2 and Orai1 function together to regulate store-independent calcium entry.
Title: SPCA2 regulates Orai1 trafficking and store independent Ca2+ entry in a model of lactation.
Atp2c2 transcription is regulated by MIST1
Title: MIST1 regulates the pancreatic acinar cell expression of Atp2c2, the gene encoding secretory pathway calcium ATPase 2.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Homology

Homologs of the Atp2c2 gene: The Atp2c2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and frog.
Orthologs from Annotation Pipeline: 346 organisms have orthologs with human gene Atp2c2
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables P-type calcium transporter activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables P-type calcium transporter activity	ISO Inferred from Sequence Orthology more info
enables P-type manganese transporter activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within mammary gland epithelium development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in manganese ion transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of calcium ion import	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in trans-Golgi network membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: calcium-transporting ATPase type 2C member 2

Names: ATPase 2C2; Ca(2+)/Mn(2+)-ATPase 2C2; Secretory pathway Ca(2+)-ATPase 2; secretory pathway Ca(2+)-transporting ATPase type 2; secretory pathway Ca2+-ATPase

NP_081198.1

EC 7.2.2.10

XP_006531407.1

EC 7.2.2.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026922.1 → NP_081198.1 calcium-transporting ATPase type 2C member 2

See identical proteins and their annotated locations for NP_081198.1

Status: VALIDATED

Source sequence(s)

AC104882, AC161435

Consensus CDS

CCDS52684.1

UniProtKB/Swiss-Prot

A7L9Z8, Q5DU19

Related

ENSMUSP00000092794.4, ENSMUST00000095171.5

Conserved Domains (6) summary

TIGR01522
Location:54 → 929

ATPase-IIA2_Ca; golgi membrane calcium-translocating P-type ATPase

COG4087
Location:584 → 707

COG4087; Soluble P-type ATPase [General function prediction only]

pfam00122
Location:135 → 366

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:754 → 927

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam00690
Location:61 → 123

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

pfam13246
Location:439 → 521

Cation_ATPase; Cation transport ATPase (P-type)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

120426748..120484457

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006531344.2 → XP_006531407.1 calcium-transporting ATPase type 2C member 2 isoform X1

Conserved Domains (1) summary

cl21460
Location:1 → 747

HAD_like; Haloacid Dehalogenase-like Hydrolases