Nupr1l nuclear protein transcriptional regulator 1 like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nupr1lprovided by MGI
Official Full Name: nuclear protein transcriptional regulator 1 likeprovided by MGI
Primary source: MGI:MGI:1923099
See related: Ensembl:ENSMUSG00000095789 AllianceGenome:MGI:1923099
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nupr2; 1810010E01Rik; 4930579G22Rik
Summary: Predicted to be involved in several processes, including cellular response to starvation; negative regulation of cell population proliferation; and negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human NUPR2 (nuclear protein 2, transcriptional regulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 183.7) and genital fat pad adult (RPKM 7.7) See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 5 G1.3; 5

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (129937381..129942629)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (129908540..129913788)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

NoName (e-PCR)
- UniSTS:493046

Homology

Homologs of the Nupr1l gene: The Nupr1l gene is conserved in human, chimpanzee, Rhesus monkey, and rat.
Orthologs from Annotation Pipeline: 204 organisms have orthologs with human gene Nupr1l
Orthologs

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cellular response to starvation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: nuclear protein 2

Names: nuclear transcriptional regulator 1-like protein; nuclear transcriptional regulator protein 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359308.1 → NP_001346237.1 nuclear protein 2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AC164071, AK016320

Consensus CDS

CCDS51654.1

UniProtKB/Swiss-Prot

Q9D923

Related

ENSMUSP00000142125.2, ENSMUST00000194521.2

Conserved Domains (1) summary

pfam10195
Location:31 → 84

Phospho_p8; DNA-binding nuclear phosphoprotein p8
NM_026916.3 → NP_081192.2 nuclear protein 2

See identical proteins and their annotated locations for NP_081192.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.

Source sequence(s)

BC100444, CJ051706, EL963130

Consensus CDS

CCDS51654.1

UniProtKB/Swiss-Prot

Q497P3, Q9D923

Related

ENSMUSP00000141660.2, ENSMUST00000195766.6

Conserved Domains (1) summary

pfam10195
Location:31 → 84

Phospho_p8; DNA-binding nuclear phosphoprotein p8