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Mitd1 MIT, microtubule interacting and transport, domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 69028, updated on 5-Mar-2024

Summary

Official Symbol
Mitd1provided by MGI
Official Full Name
MIT, microtubule interacting and transport, domain containing 1provided by MGI
Primary source
MGI:MGI:1916278
See related
Ensembl:ENSMUSG00000026088 AllianceGenome:MGI:1916278
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1500032H18Rik
Summary
Predicted to enable identical protein binding activity; phosphatidylinositol binding activity; and protein domain specific binding activity. Predicted to be involved in midbody abscission and negative regulation of protein binding activity. Predicted to act upstream of or within cell division. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be extrinsic component of membrane. Predicted to colocalize with midbody. Orthologous to human MITD1 (microtubule interacting and trafficking domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 6.1), liver E14 (RPKM 4.6) and 28 other tissues See more
Orthologs
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Genomic context

See Mitd1 in Genome Data Viewer
Location:
1 B; 1 16.13 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (37913882..37929530, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (37874801..37890449, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene capping protein inhibiting regulator of actin like Neighboring gene predicted gene, 39628 Neighboring gene testis specific 10 Neighboring gene STARR-seq mESC enhancer starr_00684 Neighboring gene STARR-positive B cell enhancer mm9_chr1:37921599-37921900 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:37922129-37922238 Neighboring gene lipoyltransferase 1 Neighboring gene mitochondrial ribosomal protein L30 Neighboring gene lysozyme G-like 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in midbody abscission IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in midbody abscission ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with midbody IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with midbody ISO
Inferred from Sequence Orthology
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
MIT domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356262.1NP_001343191.1  MIT domain-containing protein 1

    Status: VALIDATED

    Source sequence(s)
    AC119189
    Consensus CDS
    CCDS35542.1
    UniProtKB/Swiss-Prot
    Q8VDV8, Q9DB13
    Related
    ENSMUSP00000123009.2, ENSMUST00000139725.8
    Conserved Domains (2) summary
    cd02683
    Location:1086
    MIT_1; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with unknown function, co-occuring with an as yet undescribed domain. The molecular function of the MIT domain is unclear.
    pfam16565
    Location:100242
    MIT_C; Phospholipase D-like domain at C-terminus of MIT
  2. NM_026913.3NP_081189.1  MIT domain-containing protein 1

    See identical proteins and their annotated locations for NP_081189.1

    Status: VALIDATED

    Source sequence(s)
    AC119189
    Consensus CDS
    CCDS35542.1
    UniProtKB/Swiss-Prot
    Q8VDV8, Q9DB13
    Related
    ENSMUSP00000027257.9, ENSMUST00000027257.10
    Conserved Domains (2) summary
    cd02683
    Location:1086
    MIT_1; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with unknown function, co-occuring with an as yet undescribed domain. The molecular function of the MIT domain is unclear.
    pfam16565
    Location:100242
    MIT_C; Phospholipase D-like domain at C-terminus of MIT

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    37913882..37929530 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017322349.2XP_017177838.1  MIT domain-containing protein 1 isoform X2

    Conserved Domains (1) summary
    pfam16565
    Location:68181
    MIT_C; Phospholipase D-like domain at C-terminus of MIT
  2. XM_036153403.1XP_036009296.1  MIT domain-containing protein 1 isoform X1

    Conserved Domains (2) summary
    cd02683
    Location:1086
    MIT_1; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with unknown function, co-occuring with an as yet undescribed domain. The molecular function of the MIT domain is unclear.
    cl02780
    Location:100198
    MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and Trafficking molecules) domains, as well as in some bacterial proteins. The function of this domain is unknown.

RNA

  1. XR_003946501.1 RNA Sequence