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Pot1b protection of telomeres 1B [ Rattus norvegicus (Norway rat) ]

Gene ID: 690237, updated on 30-May-2026
Official Symbol
Pot1bprovided by RGD
Official Full Name
protection of telomeres 1Bprovided by RGD
Primary source
RGD:1582873
See related
Ensembl:ENSRNOG00000047439 AllianceGenome:RGD:1582873
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable G-rich strand telomeric DNA binding activity and telomerase inhibitor activity. Predicted to be involved in regulation of telomere maintenance via telomerase and telomere capping. Predicted to be part of nuclear telomere cap complex. Human ortholog(s) of this gene implicated in colorectal cancer; familial melanoma; hepatocellular carcinoma; lung cancer; and ovarian cancer. Orthologous to human POT1 (protection of telomeres 1). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Thymus (RPKM 63.9), Spleen (RPKM 44.3) and 9 other tissues See more
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Try the new Transcripts and proteins table
See Pot1b in Genome Data Viewer
Location:
9q12
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (9997508..10055752, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (9670355..9728624, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (7845697..7902270, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene SIK family kinase 3, pseudogene 1 Neighboring gene vomeronasal 2 receptor, 77 Neighboring gene U6 spliceosomal RNA Neighboring gene Nedd4 binding protein 1, pseudogene 2 Neighboring gene 60S ribosomal protein L7 pseudogene Neighboring gene adhesion G protein-coupled receptor E4 Neighboring gene vomeronasal 2 receptor, pseudogene 138

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G-rich strand telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables telomerase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of telomere maintenance via telomerase IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in telomere capping IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of nuclear telomere cap complex IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
protection of telomeres protein 1-like

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    9997508..10055752 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063267869.1 → XP_063123939.1  protection of telomeres protein 1-like isoform X6

    UniProtKB/TrEMBL
    A0ABK0L0J0, M0R4T5
    Related
    ENSRNOP00000064381.4, ENSRNOT00000072684.4

  2. XM_039084415.2 → XP_038940343.1  protection of telomeres protein 1-like isoform X2

    UniProtKB/TrEMBL
    A0ABK0L0J0
    Conserved Domains (3) summary
    smart00976
    Location:11 → 141
    Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
    cd20374
    Location:345 → 650
    Pot1C; Protection Of Telomeres Protein 1 (POT1) C-terminal region
    pfam16686
    Location:153 → 299
    POT1PC; ssDNA-binding domain of telomere protection protein

  3. XM_006244268.4 → XP_006244330.1  protection of telomeres protein 1-like isoform X4

    See identical proteins and their annotated locations for XP_006244330.1

    UniProtKB/TrEMBL
    A0A0G2JY35, A0ABK0L0J0
    Related
    ENSRNOP00000070503.3, ENSRNOT00000080575.3
    Conserved Domains (2) summary
    smart00976
    Location:11 → 141
    Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
    cd04498
    Location:161 → 279
    hPOT1_OB2; hPOT1_OB2: A subfamily of OB folds similar to the second OB fold (OB2) of human protection of telomeres 1 protein (hPOT1). POT1 proteins bind to the single-stranded (ss) 3-prime ends of the telomere. hPOT1 binds specifically to ss telomeric DNA repeats ...

  4. XM_063267870.1 → XP_063123940.1  protection of telomeres protein 1-like isoform X6

    UniProtKB/TrEMBL
    A0ABK0L0J0, M0R4T5

  5. XM_063267866.1 → XP_063123936.1  protection of telomeres protein 1-like isoform X4

    UniProtKB/TrEMBL
    A0A0G2JY35, A0ABK0L0J0
    Related
    ENSRNOP00000101595.1, ENSRNOT00000149606.1

  6. XM_039084421.2 → XP_038940349.1  protection of telomeres protein 1-like isoform X2

    UniProtKB/TrEMBL
    A0ABK0L0J0
    Conserved Domains (3) summary
    smart00976
    Location:11 → 141
    Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
    cd20374
    Location:345 → 650
    Pot1C; Protection Of Telomeres Protein 1 (POT1) C-terminal region
    pfam16686
    Location:153 → 299
    POT1PC; ssDNA-binding domain of telomere protection protein

  7. XM_063267871.1 → XP_063123941.1  protection of telomeres protein 1-like isoform X7

  8. XM_039084417.2 → XP_038940345.1  protection of telomeres protein 1-like isoform X2

    UniProtKB/TrEMBL
    A0ABK0L0J0
    Conserved Domains (3) summary
    smart00976
    Location:11 → 141
    Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
    cd20374
    Location:345 → 650
    Pot1C; Protection Of Telomeres Protein 1 (POT1) C-terminal region
    pfam16686
    Location:153 → 299
    POT1PC; ssDNA-binding domain of telomere protection protein

  9. XM_039084416.2 → XP_038940344.1  protection of telomeres protein 1-like isoform X2

    UniProtKB/TrEMBL
    A0ABK0L0J0
    Conserved Domains (3) summary
    smart00976
    Location:11 → 141
    Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
    cd20374
    Location:345 → 650
    Pot1C; Protection Of Telomeres Protein 1 (POT1) C-terminal region
    pfam16686
    Location:153 → 299
    POT1PC; ssDNA-binding domain of telomere protection protein

  10. XM_063267867.1 → XP_063123937.1  protection of telomeres protein 1-like isoform X4

    UniProtKB/TrEMBL
    A0A0G2JY35, A0ABK0L0J0

  11. XM_039084419.2 → XP_038940347.1  protection of telomeres protein 1-like isoform X2

    UniProtKB/TrEMBL
    A0ABK0L0J0
    Conserved Domains (3) summary
    smart00976
    Location:11 → 141
    Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
    cd20374
    Location:345 → 650
    Pot1C; Protection Of Telomeres Protein 1 (POT1) C-terminal region
    pfam16686
    Location:153 → 299
    POT1PC; ssDNA-binding domain of telomere protection protein

  12. XM_039084422.2 → XP_038940350.1  protection of telomeres protein 1-like isoform X2

    UniProtKB/TrEMBL
    A0ABK0L0J0
    Conserved Domains (3) summary
    smart00976
    Location:11 → 141
    Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
    cd20374
    Location:345 → 650
    Pot1C; Protection Of Telomeres Protein 1 (POT1) C-terminal region
    pfam16686
    Location:153 → 299
    POT1PC; ssDNA-binding domain of telomere protection protein

  13. XM_063267865.1 → XP_063123935.1  protection of telomeres protein 1-like isoform X4

    UniProtKB/TrEMBL
    A0A0G2JY35, A0ABK0L0J0

  14. XM_039084418.1 → XP_038940346.1  protection of telomeres protein 1-like isoform X2

    UniProtKB/TrEMBL
    A0ABK0L0J0
    Conserved Domains (3) summary
    smart00976
    Location:11 → 141
    Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
    cd20374
    Location:345 → 650
    Pot1C; Protection Of Telomeres Protein 1 (POT1) C-terminal region
    pfam16686
    Location:153 → 299
    POT1PC; ssDNA-binding domain of telomere protection protein

  15. XM_063267868.1 → XP_063123938.1  protection of telomeres protein 1-like isoform X5

    UniProtKB/TrEMBL
    A0ABK0L0J0

  16. XM_063267864.1 → XP_063123934.1  protection of telomeres protein 1-like isoform X3

    UniProtKB/TrEMBL
    A0ABK0L0J0

  17. XM_063267863.1 → XP_063123933.1  protection of telomeres protein 1-like isoform X1

    UniProtKB/TrEMBL
    A0ABK0L0J0

  18. XM_039084426.2 → XP_038940354.1  protection of telomeres protein 1-like isoform X9

    Conserved Domains (1) summary
    cd20374
    Location:18 → 323
    Pot1C; Protection Of Telomeres Protein 1 (POT1) C-terminal region

  19. XM_063267872.1 → XP_063123942.1  protection of telomeres protein 1-like isoform X8

    UniProtKB/TrEMBL
    A0ABK0L0J0

RNA

  1. XR_010054687.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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