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Oxct1 3-oxoacid CoA transferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 690163, updated on 10-Jul-2024

Summary

Symbol
Oxct1provided by RGD
Full Name
3-oxoacid CoA transferase 1provided by RGD
Primary source
RGD:1584008
See related
EnsemblRapid:ENSRNOG00000043094 AllianceGenome:RGD:1584008
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
SCOT
Summary
Enables 3-oxoacid CoA-transferase activity and identical protein binding activity. Involved in several processes, including animal organ development; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and response to ethanol. Located in mitochondrion. Biomarker of obesity and type 2 diabetes mellitus. Orthologous to human OXCT1 (3-oxoacid CoA-transferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 3677.2), Kidney (RPKM 1613.1) and 6 other tissues See more
Orthologs
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Genomic context

See Oxct1 in Genome Data Viewer
Location:
2q16
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (54963964..55112303)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (53236370..53384715)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (53859738..54007733)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene F-box protein 4 Neighboring gene RAB7A interacting MON1-CCZ1 complex subunit 1 Neighboring gene eukaryotic translation elongation factor 1 alpha 1, pseudogene 13 Neighboring gene phosphatidylinositol-specific phospholipase C, X domain containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC187935

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables CoA-transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables succinyl-CoA:3-oxo-acid CoA-transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables succinyl-CoA:3-oxo-acid CoA-transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables succinyl-CoA:3-oxo-acid CoA-transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables succinyl-CoA:3-oxo-acid CoA-transferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in adipose tissue development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular ketone body metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular ketone body metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within cellular ketone body metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular ketone body metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in heart development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in ketone body catabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within ketone body catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in ketone catabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within ketone catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hormone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nutrient IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to starvation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
Names
scot-S
somatic-type succinyl-CoA:3-oxoacid CoA-transferase
succinyl-CoA:3-ketoacid CoA transferase
succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial-like
succinyl-CoA:3-oxoacid CoA transferase
NP_001121052.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127580.1NP_001121052.1  succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001121052.1

    Status: PROVISIONAL

    Source sequence(s)
    BC166478
    UniProtKB/Swiss-Prot
    B2GV06
    UniProtKB/TrEMBL
    A0A8L2UNL5
    Related
    ENSRNOP00000090363.2, ENSRNOT00000107045.2
    Conserved Domains (3) summary
    COG1788
    Location:41274
    AtoD; Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid transport and metabolism]
    COG4670
    Location:48517
    YdiF; Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid transport and metabolism]
    cl00339
    Location:300508
    SugarP_isomerase; SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    54963964..55112303
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)