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Zfp580 zinc finger protein 580 [ Mus musculus (house mouse) ]

Gene ID: 68992, updated on 26-Sep-2022

Summary

Official Symbol
Zfp580provided by MGI
Official Full Name
zinc finger protein 580provided by MGI
Primary source
MGI:MGI:1916242
See related
Ensembl:ENSMUSG00000055633 AllianceGenome:MGI:1916242
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf580; 1500015O20Rik
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including cellular response to hydrogen peroxide; positive regulation of cell migration; and regulation of gene expression. Predicted to act upstream of or within chemotaxis and inflammatory response. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including aorta; endocrine gland; genitourinary system; nervous system; and trachea. Orthologous to human ZNF580 (zinc finger protein 580). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 28.1), adrenal adult (RPKM 21.3) and 23 other tissues See more
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Genomic context

See Zfp580 in Genome Data Viewer
Location:
7; 7 A1
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (5041682..5056722)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (5038519..5053723)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 865 Neighboring gene zinc finger protein 784 Neighboring gene predicted gene 15510 Neighboring gene coiled-coil domain containing 106 Neighboring gene U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026900.1NP_081176.1  zinc finger protein 580

    See identical proteins and their annotated locations for NP_081176.1

    Status: VALIDATED

    Source sequence(s)
    AC162893, BC066001
    Consensus CDS
    CCDS51982.1
    UniProtKB/Swiss-Prot
    Q9DB38
    UniProtKB/TrEMBL
    A0A6P5Q6Z0
    Related
    ENSMUSP00000065861.6, ENSMUST00000069324.7
    Conserved Domains (2) summary
    sd00017
    Location:94114
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:120142
    zf-C2H2; Zinc finger, C2H2 type

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    5041682..5056722
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242962.2XP_030098822.1  zinc finger protein 580 isoform X2

  2. XM_030242961.2XP_030098821.1  zinc finger protein 580 isoform X1

  3. XM_036153412.1XP_036009305.1  zinc finger protein 580 isoform X2