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Clec2dl1 C-type lectin domain family 2 member D-like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 689790, updated on 8-Apr-2026
Official Symbol
Clec2dl1provided by RGD
Official Full Name
C-type lectin domain family 2 member D-like 1provided by RGD
Primary source
RGD:1588698
See related
Ensembl:ENSRNOG00000072423 AllianceGenome:RGD:1588698
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Clec2d6
Summary
Predicted to enable natural killer cell lectin-like receptor binding activity. Predicted to be active in external side of plasma membrane. Orthologous to human CLEC2D (C-type lectin domain family 2 member D). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Liver (RPKM 18.1), Thymus (RPKM 8.7) and 7 other tissues See more
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Try the new Transcripts and proteins table
See Clec2dl1 in Genome Data Viewer
Location:
4q42
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (163949688..163960935)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (162263635..162274882)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (162391309..162402569)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene C-type lectin domain family 2 member D2 like 2 Neighboring gene C-type lectin domain family 2, member D Neighboring gene protein phosphatase 2, regulatory subunit B', alpha like 1 Neighboring gene uncharacterized LOC102549299 Neighboring gene C-type lectin domain family 2, member G like 1 Neighboring gene chromobox 3 like 3 Neighboring gene uncharacterized LOC120102406

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Cytomegalovirus evasion of innate immunity by subversion of the NKR-P1B:Clr-b missing-self axis. Voigt S, et al. Immunity, 2007 May. PMID 17462921
  2. Two major groups of rat NKR-P1 receptors can be distinguished based on chromosomal localization, phylogenetic analysis and Clr ligand binding. Kveberg L, et al. Eur J Immunol, 2009 Feb. PMID 19130483
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables natural killer cell lectin-like receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables receptor ligand activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in NK T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
C-type lectin domain family 2 member D6

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085404.2 → NP_001078873.1  C-type lectin domain family 2 member D6

    See identical proteins and their annotated locations for NP_001078873.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    A4KWA8
    UniProtKB/TrEMBL
    B7TXW3
    Related
    ENSRNOP00000048461.2, ENSRNOT00000047790.4
    Conserved Domains (1) summary
    cd03593
    Location:112 → 224
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    163949688..163960935
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008763333.4 → XP_008761555.1  C-type lectin domain family 2 member D6 isoform X1

    UniProtKB/TrEMBL
    A0ABK0LCM5
    Related
    ENSRNOP00000103094.1, ENSRNOT00000159982.1
    Conserved Domains (1) summary
    cd03593
    Location:56 → 168
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4KWA8.1 GenPept UniProtKB/Swiss-Prot:A4KWA8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.