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Srrm4 serine/arginine repetitive matrix 4 [ Mus musculus (house mouse) ]

Gene ID: 68955, updated on 9-May-2024

Summary

Official Symbol
Srrm4provided by MGI
Official Full Name
serine/arginine repetitive matrix 4provided by MGI
Primary source
MGI:MGI:1916205
See related
Ensembl:ENSMUSG00000063919 AllianceGenome:MGI:1916205
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
bv; nSR100; mKIAA1853; 1500001A10Rik; B230202K19Rik
Summary
Enables mRNA binding activity. Involved in several processes, including mRNA processing; nervous system development; and regulation of alternative mRNA splicing, via spliceosome. Acts upstream of or within sensory perception of sound. Located in nucleus. Is expressed in central nervous system and inner ear. Orthologous to human SRRM4 (serine/arginine repetitive matrix 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E14 (RPKM 8.0), whole brain E14.5 (RPKM 7.4) and 6 other tissues See more
Orthologs
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Genomic context

See Srrm4 in Genome Data Viewer
Location:
5 F; 5 56.45 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (116577331..116729882, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (116439268..116592562, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14153 Neighboring gene predicted gene, 36841 Neighboring gene heat shock protein 8 Neighboring gene predicted gene, 42009 Neighboring gene serine/arginine repetitive matrix 4, opposite strand Neighboring gene STARR-seq mESC enhancer starr_14160 Neighboring gene glutathione S-transferase mu 2 (muscle), pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_14161 Neighboring gene STARR-seq mESC enhancer starr_14162 Neighboring gene predicted gene, 29843

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Bronx waltzer
GeneReviews: Not available
flopsy
GeneReviews: Not available

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Spontaneous (1) 
  • Targeted (3)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/arginine repetitive matrix protein 4
Names
neural-specific SR-related protein of 100 kDa
neural-specific serine/arginine repetitive splicing factor of 100 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403397.1NP_001390326.1  serine/arginine repetitive matrix protein 4 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC115972, AC156994
    UniProtKB/Swiss-Prot
    Q8BKA3, Q8R1S5, Q9CW37
    UniProtKB/TrEMBL
    J9QHX6
  2. NM_001428966.1NP_001415895.1  serine/arginine repetitive matrix protein 4 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC115972, AC156994
  3. NM_026886.4NP_081162.1  serine/arginine repetitive matrix protein 4 isoform a

    See identical proteins and their annotated locations for NP_081162.1

    Status: VALIDATED

    Source sequence(s)
    AC115972, AC156994
    Consensus CDS
    CCDS19601.1
    UniProtKB/Swiss-Prot
    Q8BKA3, Q8R1S5, Q9CW37
    UniProtKB/TrEMBL
    J9QHX6
    Related
    ENSMUSP00000075488.6, ENSMUST00000076124.7
    Conserved Domains (1) summary
    pfam15230
    Location:463515
    SRRM_C; Serine/arginine repetitive matrix protein C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    116577331..116729882 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)