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Tmco1 transmembrane and coiled-coil domains 1 [ Mus musculus (house mouse) ]

Gene ID: 68944, updated on 12-May-2024

Summary

Official Symbol
Tmco1provided by MGI
Official Full Name
transmembrane and coiled-coil domains 1provided by MGI
Primary source
MGI:MGI:1921173
See related
Ensembl:ENSMUSG00000052428 AllianceGenome:MGI:1921173
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ESTM39; 1190006A08Rik; 4930403O06Rik
Summary
Predicted to enable calcium channel activity and ribosome binding activity. Involved in calcium ion transmembrane transport and endoplasmic reticulum calcium ion homeostasis. Predicted to be integral component of endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Is expressed in clavicle; mandible; maxilla; and rib. Orthologous to human TMCO1 (transmembrane and coiled-coil domains 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 17.2), kidney adult (RPKM 12.2) and 28 other tissues See more
Orthologs
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Genomic context

See Tmco1 in Genome Data Viewer
Location:
1 H2.3; 1 74.69 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (167136239..167161547)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (167308670..167333978)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 2453 Neighboring gene microRNA 6347 Neighboring gene STARR-positive B cell enhancer ABC_E9494 Neighboring gene STARR-positive B cell enhancer ABC_E9495 Neighboring gene STARR-positive B cell enhancer ABC_E10054 Neighboring gene STARR-positive B cell enhancer ABC_E8779 Neighboring gene STARR-positive B cell enhancer ABC_E2583 Neighboring gene predicted gene, 24182 Neighboring gene aldehyde dehydrogenase 9, subfamily A1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables ribosome binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of multi-pass translocon complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
calcium load-activated calcium channel
Names
CLAC channel
GEL complex subunit TMCO1
transmembrane and coiled-coil domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039483.1NP_001034572.1  calcium load-activated calcium channel

    See identical proteins and their annotated locations for NP_001034572.1

    Status: VALIDATED

    Source sequence(s)
    AC113970, AK004504, AK037709
    Consensus CDS
    CCDS15456.1
    UniProtKB/Swiss-Prot
    Q3TS11, Q921L3
    UniProtKB/TrEMBL
    A0A0A6YVS2, Q3V4A0
    Related
    ENSMUSP00000142042.2, ENSMUST00000195015.6
    Conserved Domains (1) summary
    pfam01956
    Location:8165
    DUF106; Integral membrane protein DUF106

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    167136239..167161547
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_026881.2: Suppressed sequence

    Description
    NM_026881.2: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.