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Dgki diacylglycerol kinase, iota [ Rattus norvegicus (Norway rat) ]

Gene ID: 688705, updated on 12-Jan-2022

Summary

Official Symbol
Dgkiprovided by RGD
Official Full Name
diacylglycerol kinase, iotaprovided by RGD
Primary source
RGD:735049
See related
Ensembl:ENSRNOG00000026705
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
rDGKi-3
Summary
Enables diacylglycerol kinase activity. Involved in diacylglycerol metabolic process; lipid phosphorylation; and phosphatidic acid biosynthetic process. Located in several cellular components, including excitatory synapse; neuronal cell body; and postsynaptic density. Is active in glutamatergic synapse and synaptic vesicle. Is extrinsic component of postsynaptic density membrane and extrinsic component of presynaptic active zone membrane. Orthologous to human DGKI (diacylglycerol kinase iota). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Brain (RPKM 114.6), Uterus (RPKM 32.4) and 3 other tissues See more
Orthologs
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Genomic context

See Dgki in Genome Data Viewer
Location:
4q22
Exon count:
35
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (65410878..65872733, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (64365115..64831473, complement)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene cholinergic receptor, muscarinic 2 Neighboring gene microRNA 490 Neighboring gene pleiotrophin Neighboring gene cAMP responsive element binding protein 3-like 2 Neighboring gene aldo-keto reductase family 1, member D1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD+ kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables diacylglycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables diacylglycerol kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables diacylglycerol kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables diacylglycerol kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in diacylglycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in diacylglycerol metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
involved_in glycerolipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within habituation ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lipid phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipid phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neurotransmitter secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidic acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of long-term synaptic depression ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
 
located_in axon terminus IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in excitatory synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extrinsic component of postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extrinsic component of postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extrinsic component of presynaptic active zone membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extrinsic component of presynaptic active zone membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
part_of guanyl-nucleotide exchange factor complex ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynaptic active zone IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
diacylglycerol kinase iota
Names
DAG kinase iota
DGK-iota
diacylglycerol kinase iota-3
diglyceride kinase iota
NP_942077.2
XP_006236395.1
XP_017448383.1
XP_038964295.1
XP_038964296.1
XP_038964297.1
XP_038964298.1
XP_038964299.1
XP_038964300.1
XP_038964302.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198782.2NP_942077.2  diacylglycerol kinase iota

    Status: VALIDATED

    Source sequence(s)
    AB058962, AW526027, CN544764, JACYVU010000141
    UniProtKB/TrEMBL
    F1MAB7, Q810C5
    Related
    ENSRNOP00000034571.3, ENSRNOT00000033268.5
    Conserved Domains (7) summary
    smart00045
    Location:521678
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:373494
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG0666
    Location:8481047
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:945976
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:9151010
    Ank_2; Ankyrin repeats (3 copies)
    cd20850
    Location:163235
    C1_DGKiota_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase iota (DAG kinase iota) and similar proteins
    cd20896
    Location:244318
    C1_DGKiota_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase iota (DAG kinase iota) and similar proteins

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    65410878..65872733 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108371.1XP_038964299.1  diacylglycerol kinase iota isoform X7

    Conserved Domains (7) summary
    smart00045
    Location:457614
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:309430
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG0666
    Location:8051004
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:902933
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:872967
    Ank_2; Ankyrin repeats (3 copies)
    cd20850
    Location:163235
    C1_DGKiota_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase iota (DAG kinase iota) and similar proteins
    cl00040
    Location:246264
    C1; protein kinase C conserved region 1 (C1 domain) superfamily
  2. XM_039108370.1XP_038964298.1  diacylglycerol kinase iota isoform X6

    Conserved Domains (7) summary
    smart00045
    Location:458615
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:310431
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG0666
    Location:8061005
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:903934
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:873968
    Ank_2; Ankyrin repeats (3 copies)
    cd20850
    Location:163235
    C1_DGKiota_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase iota (DAG kinase iota) and similar proteins
    cl00040
    Location:246264
    C1; protein kinase C conserved region 1 (C1 domain) superfamily
  3. XM_039108368.1XP_038964296.1  diacylglycerol kinase iota isoform X2

    Conserved Domains (7) summary
    smart00045
    Location:561718
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:413534
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG0666
    Location:9091108
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:10061037
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:9761071
    Ank_2; Ankyrin repeats (3 copies)
    cd20850
    Location:163235
    C1_DGKiota_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase iota (DAG kinase iota) and similar proteins
    cd20896
    Location:244318
    C1_DGKiota_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase iota (DAG kinase iota) and similar proteins
  4. XM_039108367.1XP_038964295.1  diacylglycerol kinase iota isoform X1

    Conserved Domains (7) summary
    smart00045
    Location:562719
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:414535
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG0666
    Location:9101109
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:10071038
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:9771072
    Ank_2; Ankyrin repeats (3 copies)
    cd20850
    Location:163235
    C1_DGKiota_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase iota (DAG kinase iota) and similar proteins
    cd20896
    Location:244318
    C1_DGKiota_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase iota (DAG kinase iota) and similar proteins
  5. XM_017592894.2XP_017448383.1  diacylglycerol kinase iota isoform X5

  6. XM_006236333.4XP_006236395.1  diacylglycerol kinase iota isoform X4

    Related
    ENSRNOP00000079887.1, ENSRNOT00000120235.1
    Conserved Domains (7) summary
    smart00045
    Location:521678
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:373494
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:369688
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    cd00204
    Location:9391053
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00130
    Location:246305
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam12796
    Location:9361031
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:966997
    ANK; ANK repeat [structural motif]
  7. XM_039108369.1XP_038964297.1  diacylglycerol kinase iota isoform X3

    Conserved Domains (7) summary
    smart00045
    Location:562719
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:414535
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG0666
    Location:8891088
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:9861017
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:9561051
    Ank_2; Ankyrin repeats (3 copies)
    cd20850
    Location:163235
    C1_DGKiota_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase iota (DAG kinase iota) and similar proteins
    cd20896
    Location:244318
    C1_DGKiota_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase iota (DAG kinase iota) and similar proteins
  8. XM_039108372.1XP_038964300.1  diacylglycerol kinase iota isoform X8

    Conserved Domains (4) summary
    smart00046
    Location:414535
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd20850
    Location:163235
    C1_DGKiota_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase iota (DAG kinase iota) and similar proteins
    cd20896
    Location:244318
    C1_DGKiota_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase iota (DAG kinase iota) and similar proteins
    cl02440
    Location:562624
    DAGK_acc; Diacylglycerol kinase accessory domain
  9. XM_039108374.1XP_038964302.1  diacylglycerol kinase iota isoform X9

    Related
    ENSRNOP00000072665.2, ENSRNOT00000079285.2
    Conserved Domains (4) summary
    smart00046
    Location:373494
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd20850
    Location:163235
    C1_DGKiota_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase iota (DAG kinase iota) and similar proteins
    cd20896
    Location:244318
    C1_DGKiota_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase iota (DAG kinase iota) and similar proteins
    cl02440
    Location:521583
    DAGK_acc; Diacylglycerol kinase accessory domain
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