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Il31ra interleukin 31 receptor A [ Rattus norvegicus (Norway rat) ]

Gene ID: 688622, updated on 11-Apr-2024

Summary

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Official Symbol
Il31raprovided by RGD
Official Full Name
interleukin 31 receptor Aprovided by RGD
Primary source
RGD:1586478
See related
Ensembl:ENSRNOG00000042080 AllianceGenome:RGD:1586478
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cytokine receptor activity and granulocyte colony-stimulating factor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; monocyte differentiation; and positive regulation of tyrosine phosphorylation of STAT protein. Predicted to act upstream of or within acute inflammatory response to antigenic stimulus; defense response to other organism; and glandular epithelial cell differentiation. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in primary localized cutaneous amyloidosis 2. Orthologous to human IL31RA (interleukin 31 receptor A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 33.3), Adrenal (RPKM 19.1) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q14
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (45851073..45922300, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (44118748..44189943, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (44333347..44408005, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100706 Neighboring gene U6 spliceosomal RNA Neighboring gene interleukin 6 cytokine family signal transducer Neighboring gene uncharacterized LOC134485838 Neighboring gene serine/arginine-rich splicing factor 3 pseudogene Neighboring gene DEAD-box helicase 4 Neighboring gene solute carrier family 38, member 9 Neighboring gene heterogeneous nuclear ribonucleoprotein R, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel type I cytokine receptor is expressed on monocytes, signals proliferation, and activates STAT-3 and STAT-5. Ghilardi N, et al. J Biol Chem, 2002 May 10. PMID 11877449
  2. IL-31-IL-31R interactions limit the magnitude of Th2 cytokine-dependent immunity and inflammation following intestinal helminth infection. Perrigoue JG, et al. J Immunol, 2009 May 15. PMID 19414760, Free PMC Article
  3. Diverse functions of reactive cysteines facilitate unique biosynthetic processes of aggregate-prone interleukin-31. Shen M, et al. Exp Cell Res, 2011 Apr 15. PMID 21182835
  4. Rat Mcs1b is concordant to the genome-wide association-identified breast cancer risk locus at human 5q11.2 and MIER3 is a candidate cancer susceptibility gene. denDekker AD, et al. Cancer Res, 2012 Nov 15. PMID 22993404, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytokine binding ISO
Inferred from Sequence Orthology
more info
  
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within acute inflammatory response to antigenic stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cell surface receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
  
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within defense response to other organism ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within glandular epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in monocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
interleukin-31 receptor subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001257278.2 → NP_001244207.1  interleukin-31 receptor subunit alpha precursor

    See identical proteins and their annotated locations for NP_001244207.1

    Status: PROVISIONAL

    Source sequence(s)
    JQ013736
    UniProtKB/TrEMBL
    H9BFG9, M0R4P7
    Related
    ENSRNOP00000046349.6, ENSRNOT00000041452.6
    Conserved Domains (2) summary
    smart00060
    Location:408 → 488
    FN3; Fibronectin type 3 domain
    cd00063
    Location:116 → 205
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    45851073..45922300 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039103156.2 → XP_038959084.1  interleukin-31 receptor subunit alpha isoform X1

    UniProtKB/TrEMBL
    F1LZR4, M0R4P7
    Conserved Domains (2) summary
    smart00060
    Location:408 → 488
    FN3; Fibronectin type 3 domain
    cd00063
    Location:116 → 205
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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