Pih1d1 PIH1 domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pih1d1provided by MGI
Official Full Name: PIH1 domain containing 1provided by MGI
Primary source: MGI:MGI:1916095
See related: Ensembl:ENSMUSG00000003423 AllianceGenome:MGI:1916095
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nop17; 1110061L23Rik; 4933413A04Rik
Summary: Predicted to enable several functions, including RNA polymerase I core promoter sequence-specific DNA binding activity; enzyme binding activity; and phosphoprotein binding activity. Predicted to be involved in several processes, including box C/D snoRNP assembly; positive regulation of signal transduction; and regulation of cellular protein metabolic process. Located in nucleus. Orthologous to human PIH1D1 (PIH1 domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 78.1), CNS E11.5 (RPKM 23.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 29.16 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (44800036..44809489)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (45150613..45160065)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables histone reader activity	ISO Inferred from Sequence Orthology more info
enables phosphoprotein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in TORC1 complex assembly	ISO Inferred from Sequence Orthology more info
involved_in box C/D snoRNP assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in box C/D snoRNP assembly	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glucose mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	ISO Inferred from Sequence Orthology more info
involved_in rRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in snoRNA localization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of R2TP complex	IBA Inferred from Biological aspect of Ancestor more info
part_of R2TP complex	ISO Inferred from Sequence Orthology more info
part_of RPAP3/R2TP/prefoldin-like complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of pre-snoRNP complex	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: PIH1 domain-containing protein 1

Names: nucleolar protein 17 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001278207.1 → NP_001265136.1 PIH1 domain-containing protein 1

See identical proteins and their annotated locations for NP_001265136.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.

Source sequence(s)

AK004341

Consensus CDS

CCDS21232.1

UniProtKB/Swiss-Prot

Q6NV90, Q9CQJ2

Related

ENSMUSP00000148186.2, ENSMUST00000210139.2

Conserved Domains (2) summary

pfam18201
Location:215 → 286

PIH1_CS; PIH1 CS-like domain

cl00175
Location:33 → 180

alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.
NM_001285904.2 → NP_001272833.1 PIH1 domain-containing protein 1

See identical proteins and their annotated locations for NP_001272833.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.

Source sequence(s)

AC149868, BC068254

Consensus CDS

CCDS21232.1

UniProtKB/Swiss-Prot

Q6NV90, Q9CQJ2

Related

ENSMUSP00000103441.2, ENSMUST00000107811.4

Conserved Domains (2) summary

pfam18201
Location:215 → 286

PIH1_CS; PIH1 CS-like domain

cl00175
Location:33 → 180

alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.
NM_029406.4 → NP_083682.1 PIH1 domain-containing protein 1

See identical proteins and their annotated locations for NP_083682.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.

Source sequence(s)

AK004341, AK146039

Consensus CDS

CCDS21232.1

UniProtKB/Swiss-Prot

Q6NV90, Q9CQJ2

Related

ENSMUSP00000082490.6, ENSMUST00000085375.13

Conserved Domains (2) summary

pfam18201
Location:215 → 286

PIH1_CS; PIH1 CS-like domain

cl00175
Location:33 → 180

alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

44800036..44809489

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006541156.2 → XP_006541219.1 PIH1 domain-containing protein 1 isoform X1

See identical proteins and their annotated locations for XP_006541219.1

UniProtKB/Swiss-Prot

Q6NV90, Q9CQJ2

Conserved Domains (2) summary

pfam18201
Location:215 → 286

PIH1_CS; PIH1 CS-like domain

cl00175
Location:33 → 180

alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.
XM_036153406.1 → XP_036009299.1 PIH1 domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

Q6NV90, Q9CQJ2

Conserved Domains (2) summary

pfam18201
Location:215 → 286

PIH1_CS; PIH1 CS-like domain

cl00175
Location:33 → 180

alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.