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TAF9 TATA-box binding protein associated factor 9 [ Homo sapiens (human) ]

Gene ID: 6880, updated on 18-Nov-2018

Summary

Official Symbol
TAF9provided by HGNC
Official Full Name
TATA-box binding protein associated factor 9provided by HGNC
Primary source
HGNC:HGNC:11542
See related
Ensembl:ENSG00000273841 MIM:600822; Vega:OTTHUMG00000099359
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TAF2G; TAFII31; TAFII32; MGC:5067; TAFII-31; TAFII-32; TAFIID32; STAF31/32
Summary
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds to the basal transcription factor GTF2B as well as to several transcriptional activators such as p53 and VP16. In human, TAF9 and AK6 (GeneID: 102157402) are two distinct genes that share 5' exons. A similar but distinct gene (TAF9L) has been found on the X chromosome and a pseudogene has been identified on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Expression
Broad expression in testis (RPKM 60.1), bone marrow (RPKM 34.1) and 25 other tissues See more
Orthologs

Genomic context

See TAF9 in Genome Data Viewer
Location:
5q13.2
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (69364743..69370013, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (68647551..68665840, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 2 Neighboring gene NADH:ubiquinone oxidoreductase subunit B9 pseudogene Neighboring gene adenylate kinase 6 Neighboring gene RAD17 checkpoint clamp loader component Neighboring gene MARVEL domain containing 2 Neighboring gene ribosomal protein S27 pseudogene 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Interaction of TFIID with the HIV-1 LTR, and therefore presumably HIV-1 Tat protein, is primarily dependent on the LTR TATA element and may also be stabilized or regulated by flanking E box motifs and basic helix-loop-helix proteins such as AP-4 and E47 PubMed
tat TATA binding protein (TBP)-associated factors (TAFs) in the TFIID complex are required for activation by transcription factors, but are dispensable for HIV-1 Tat LTR transactivation function PubMed
tat A novel function of LBP-1, restricting HIV-1 transcription at the level of elongation by preventing the binding of TFIID to the promoter, is suppressed by HIV-1 Tat, indicating Tat helps recruit TFIID to the HIV-1 LTR PubMed
tat HIV-1 Tat stabilizes the interaction of TFIIA with TFIID, and TFIIA and TFIID are required to reconstitute Tat-specific and TAR-dependent activation of HIV transcription in vitro PubMed
tat HIV-1 Tat binds, through amino acids 36-50, directly to the TBP subunit of the TFIID holoenzyme complex (which includes at least TFIID subunits p250, p125, p70, TBP, and p30), and increases the interaction of TFIID with the HIV-1 LTR promoter PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC1603, MGC3647, MGC5067

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
C2H2 zinc finger domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to RNA polymerase II general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activating transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to histone acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
p53 binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription regulatory region DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
box C/D snoRNP assembly IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to DNA damage stimulus IC
Inferred by Curator
more info
PubMed 
histone H3 acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone H3 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IC
Inferred by Curator
more info
PubMed 
negative regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of response to cytokine stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
protein stabilization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
response to interleukin-1 IMP
Inferred from Mutant Phenotype
more info
PubMed 
snRNA transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
MLL1 complex IDA
Inferred from Direct Assay
more info
PubMed 
PCAF complex IDA
Inferred from Direct Assay
more info
PubMed 
SAGA complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
STAGA complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
pre-snoRNP complex IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor TFIID complex IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor TFTC complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transcription initiation factor TFIID subunit 9
Names
RNA polymerase II TBP-associated factor subunit G
TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
transcription initiation factor TFIID 31 kD subunit
transcription initiation factor TFIID 31 kDa subunit
transcription initiation factor TFIID 32 kDa subunit
NP_001015892.1
NP_003178.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001015892.1NP_001015892.1  transcription initiation factor TFIID subunit 9

    See identical proteins and their annotated locations for NP_001015892.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longer transcript. Both variants 4 and 1 encode the same protein.
    Source sequence(s)
    AC145132, BC003400, CX784292
    Consensus CDS
    CCDS4002.1
    UniProtKB/Swiss-Prot
    Q16594
    Related
    ENSP00000370193.1, ENST00000328663.8
    Conserved Domains (1) summary
    pfam02291
    Location:9129
    TFIID-31kDa; Transcription initiation factor IID, 31kD subunit
  2. NM_003187.4NP_003178.1  transcription initiation factor TFIID subunit 9

    See identical proteins and their annotated locations for NP_003178.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 4. Both variants 4 and 1 encode the same protein.
    Source sequence(s)
    AC145132, BC003400, BG490028, BG720149
    Consensus CDS
    CCDS4002.1
    UniProtKB/Swiss-Prot
    Q16594
    Related
    ENSP00000217893.7, OTTHUMP00000278158, ENST00000217893.9, OTTHUMT00000479681
    Conserved Domains (1) summary
    pfam02291
    Location:9129
    TFIID-31kDa; Transcription initiation factor IID, 31kD subunit

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    69364743..69370013 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NW_003315917.2 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    147938..153209 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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