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Anln anillin, actin binding protein [ Mus musculus (house mouse) ]

Gene ID: 68743, updated on 18-Sep-2024

Summary

Official Symbol
Anlnprovided by MGI
Official Full Name
anillin, actin binding proteinprovided by MGI
Primary source
MGI:MGI:1920174
See related
Ensembl:ENSMUSG00000036777 AllianceGenome:MGI:1920174
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Scraps; 1110037A17Rik; 2900037I21Rik
Summary
Predicted to enable actin binding activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in several cellular components, including bleb; midbody; and nucleoplasm. Predicted to be active in actomyosin contractile ring. Is expressed in several structures, including brain and otocyst. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 8. Orthologous to human ANLN (anillin actin binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 8.2), CNS E11.5 (RPKM 7.1) and 18 other tissues See more
Orthologs
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Genomic context

See Anln in Genome Data Viewer
Location:
9 A3; 9 8.93 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (22243305..22302132, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (22331214..22389211, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23543 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene Neighboring gene 40S ribosomal protein S20 pseudogene Neighboring gene STARR-seq mESC enhancer starr_23549 Neighboring gene STARR-positive B cell enhancer ABC_E2286 Neighboring gene microtubule associated tyrosine carboxypeptidase 2 Neighboring gene STARR-seq mESC enhancer starr_23553 Neighboring gene STARR-seq mESC enhancer starr_23554 Neighboring gene STARR-positive B cell enhancer ABC_E5056 Neighboring gene retinitis pigmentosa 9 (human) Neighboring gene ribosomal protein L7A pseudogene Neighboring gene Bardet-Biedl syndrome 9

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (2)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in actomyosin contractile ring assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
 
involved_in podocyte cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in podocyte cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of bleb assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of bleb assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in septin ring organization IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
is_active_in actomyosin contractile ring IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in actomyosin contractile ring ISO
Inferred from Sequence Orthology
more info
 
located_in bleb ISO
Inferred from Sequence Orthology
more info
 
located_in bleb ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
 
located_in cell cortex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in midbody IEA
Inferred from Electronic Annotation
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
anillin
Names
actin-binding protein anillin
anillin, actin binding protein (scraps homolog, Drosophila)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001404933.1NP_001391862.1  anillin isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC093926, AC159308
  2. NM_028390.4NP_082666.2  anillin isoform 2

    See identical proteins and their annotated locations for NP_082666.2

    Status: VALIDATED

    Source sequence(s)
    AC093926, AC159308
    Consensus CDS
    CCDS22927.1
    UniProtKB/Swiss-Prot
    Q8BL79, Q8BLB3, Q8K298, Q8K2N0, Q9CUY0
    Related
    ENSMUSP00000045873.8, ENSMUST00000040912.9
    Conserved Domains (4) summary
    cd01263
    Location:9811107
    PH_anillin; Anillin Pleckstrin homology (PH) domain
    pfam00169
    Location:9841103
    PH; PH domain
    pfam08174
    Location:797950
    Anillin; Cell division protein anillin
    pfam16018
    Location:141227
    Anillin_N; Anillin N-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    22243305..22302132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242594.2XP_011240896.1  anillin isoform X3

    Conserved Domains (2) summary
    cd01263
    Location:504630
    PH_anillin; Anillin Pleckstrin homology (PH) domain
    pfam08174
    Location:302455
    Anillin; Cell division protein anillin
  2. XM_006510582.5XP_006510645.1  anillin isoform X2

    Conserved Domains (3) summary
    PHA03307
    Location:24206
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam08174
    Location:797950
    Anillin; Cell division protein anillin
    pfam16018
    Location:141227
    Anillin_N; Anillin N-terminus