Acss1 acyl-CoA synthetase short-chain family member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Acss1provided by MGI
Official Full Name: acyl-CoA synthetase short-chain family member 1provided by MGI
Primary source: MGI:MGI:1915988
See related: Ensembl:ENSMUSG00000027452 AllianceGenome:MGI:1915988
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Acas2; Acas2l; AceCS2; 1110032O15Rik
Summary: Enables acetate-CoA ligase activity and propionate-CoA ligase activity. Acts upstream of or within acetyl-CoA biosynthetic process. Located in mitochondrial matrix. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human ACSS1 (acyl-CoA synthetase short chain family member 1). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Broad expression in kidney adult (RPKM 106.8), heart adult (RPKM 84.4) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 G3; 2 74.74 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (150460031..150510160, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (150618111..150668240, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered metabolism, cell senescence, and nonalcoholic fatty liver disease.
Title: Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered metabolism, cell senescence, and nonalcoholic fatty liver disease.
Identifying Acss1, Mtfp1 and Oxct1 as key regulators and promising biomarkers of sarcopenia in various models.
Title: Identifying Acss1, Mtfp1 and Oxct1 as key regulators and promising biomarkers of sarcopenia in various models.
Activation of acetyl-CoA synthetase 2 mediates kidney injury in diabetic nephropathy.
Title: Activation of acetyl-CoA synthetase 2 mediates kidney injury in diabetic nephropathy.
acetylation of AceCS1 is cyclic and that its rhythmicity requires a functional circadian clock and the NAD(+)-dependent deacetylase SIRT1.
Title: Circadian control of fatty acid elongation by SIRT1 protein-mediated deacetylation of acetyl-coenzyme A synthetase 1.
Findings demonstrate that activation of acetate by AceCS2 plays a pivotal role in thermogenesis, especially under low-glucose or ketogenic conditions, and is crucially required for survival.
Title: Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2.
together with the trans-activation of the AceCS2 promoter, it is suggested that fasting-induced AceCS2 expression is largely contributed by KLF15
Title: A Kruppel-like factor KLF15 contributes fasting-induced transcriptional activation of mitochondrial acetyl-CoA synthetase gene AceCS2.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234552

Acss1 (e-PCR), detects polymorphism
- UniSTS:506708

AI788978 (e-PCR)
- UniSTS:165217

D2Dcr105 (e-PCR), detects polymorphism
- UniSTS:507583

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables AMP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables acetate-CoA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetate-CoA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetate-CoA ligase activity	IEA Inferred from Electronic Annotation more info
enables acetate-CoA ligase activity	ISO Inferred from Sequence Orthology more info
enables acetate-CoA ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables propionate-CoA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables propionate-CoA ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acetate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in acetate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in acetyl-CoA biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within acetyl-CoA biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in acetyl-CoA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in acetyl-CoA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in acetyl-CoA biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in acetyl-CoA biosynthetic process from acetate	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in propionate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in propionate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in small molecule metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: acetyl-coenzyme A synthetase 2-like, mitochondrial

Names: acetate--CoA ligase 2; acetyl-CoA synthetase 2; propionate--CoA ligase

NP_542142.1

EC 6.2.1.1

EC 6.2.1.17

XP_036018418.1

EC 6.2.1.1

EC 6.2.1.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080575.2 → NP_542142.1 acetyl-coenzyme A synthetase 2-like, mitochondrial precursor

See identical proteins and their annotated locations for NP_542142.1

Status: VALIDATED

Source sequence(s)

AK146568, AK173275

Consensus CDS

CCDS16859.1

UniProtKB/Swiss-Prot

Q8K0M6, Q99NB1

UniProtKB/TrEMBL

Q3TZ45, Q3UJ89, Q69Z91

Related

ENSMUSP00000028944.4, ENSMUST00000028944.4

Conserved Domains (1) summary

TIGR02188
Location:45 → 670

Ac_CoA_lig_AcsA; acetate--CoA ligase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

150460031..150510160 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162525.1 → XP_036018418.1 acetyl-coenzyme A synthetase 2-like, mitochondrial isoform X1

Conserved Domains (1) summary

cl17068
Location:46 → 355

AFD_class_I; Adenylate forming domain, Class I superfamily