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TAF2 TATA-box binding protein associated factor 2 [ Homo sapiens (human) ]

Gene ID: 6873, updated on 3-May-2020

Summary

Official Symbol
TAF2provided by HGNC
Official Full Name
TATA-box binding protein associated factor 2provided by HGNC
Primary source
HGNC:HGNC:11536
See related
Ensembl:ENSG00000064313 MIM:604912
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRT40; TAF2B; CIF150; TAFII150
Summary
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 8.1), lymph node (RPKM 6.4) and 25 other tissues See more
Orthologs

Genomic context

See TAF2 in Genome Data Viewer
Location:
8q24.12
Exon count:
30
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (119730773..119832858, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (120743014..120845074, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 2 Neighboring gene uncharacterized LOC105375727 Neighboring gene RN7SK pseudogene 153 Neighboring gene uncharacterized LOC105375728 Neighboring gene DNA replication and sister chromatid cohesion 1 Neighboring gene RNA, 7SL, cytoplasmic 396, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Interaction of TFIID with the HIV-1 LTR, and therefore presumably HIV-1 Tat protein, is primarily dependent on the LTR TATA element and may also be stabilized or regulated by flanking E box motifs and basic helix-loop-helix proteins such as AP-4 and E47 PubMed
tat TATA binding protein (TBP)-associated factors (TAFs) in the TFIID complex are required for activation by transcription factors, but are dispensable for HIV-1 Tat LTR transactivation function PubMed
tat HIV-1 Tat stabilizes the interaction of TFIIA with TFIID, and TFIIA and TFIID are required to reconstitute Tat-specific and TAR-dependent activation of HIV transcription in vitro PubMed
tat HIV-1 Tat binds, through amino acids 36-50, directly to the TBP subunit of the TFIID holoenzyme complex (which includes at least TFIID subunits p250, p125, p70, TBP, and p30), and increases the interaction of TFIID with the HIV-1 LTR promoter PubMed
tat A novel function of LBP-1, restricting HIV-1 transcription at the level of elongation by preventing the binding of TFIID to the promoter, is suppressed by HIV-1 Tat, indicating Tat helps recruit TFIID to the HIV-1 LTR PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
TFIID-class transcription factor complex binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription regulatory region sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm TAS
Traceable Author Statement
more info
 
transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor TFIID complex IDA
Inferred from Direct Assay
more info
PubMed 
NOT transcription factor TFIID complex IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor TFTC complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transcription initiation factor TFIID subunit 2
Names
150 kDa cofactor of initiator function
RNA polymerase II TBP-associated factor subunit B
TAF(II)150
TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
TATA box binding protein (TBP)-associated factor, RNA polymerase II, B, 150kD
TBP-associated factor 150 kDa
cofactor of initiator function, 150kD subunit
transcription initiation factor TFIID 150 kDa subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033911.1 RefSeqGene

    Range
    5001..107061
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003184.4NP_003175.2  transcription initiation factor TFIID subunit 2

    Status: REVIEWED

    Source sequence(s)
    AC021945, AC107960
    Consensus CDS
    CCDS34937.1
    Related
    ENSP00000367406.2, ENST00000378164.7
    Conserved Domains (1) summary
    cd09839
    Location:27541
    M1_TAF2; TATA binding protein (TBP) associated factor 2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    119730773..119832858 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013791.2XP_016869280.1  transcription initiation factor TFIID subunit 2 isoform X10

  2. XM_024447240.1XP_024303008.1  transcription initiation factor TFIID subunit 2 isoform X6

    Conserved Domains (1) summary
    cd09839
    Location:2372
    M1_TAF2; TATA binding protein (TBP) associated factor 2
  3. XM_017013790.2XP_016869279.1  transcription initiation factor TFIID subunit 2 isoform X9

    Conserved Domains (1) summary
    cl14813
    Location:14124
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
  4. XM_017013785.2XP_016869274.1  transcription initiation factor TFIID subunit 2 isoform X6

    UniProtKB/TrEMBL
    A0A024R9E6
    Conserved Domains (1) summary
    cd09839
    Location:2372
    M1_TAF2; TATA binding protein (TBP) associated factor 2
  5. XM_024447241.1XP_024303009.1  transcription initiation factor TFIID subunit 2 isoform X7

    Conserved Domains (1) summary
    cd09839
    Location:2372
    M1_TAF2; TATA binding protein (TBP) associated factor 2
  6. XM_017013779.2XP_016869268.1  transcription initiation factor TFIID subunit 2 isoform X3

  7. XM_011517259.2XP_011515561.1  transcription initiation factor TFIID subunit 2 isoform X2

    Conserved Domains (1) summary
    cd09839
    Location:27541
    M1_TAF2; TATA binding protein (TBP) associated factor 2
  8. XM_006716621.3XP_006716684.1  transcription initiation factor TFIID subunit 2 isoform X1

    Conserved Domains (1) summary
    cd09839
    Location:27541
    M1_TAF2; TATA binding protein (TBP) associated factor 2
  9. XM_024447242.1XP_024303010.1  transcription initiation factor TFIID subunit 2 isoform X8

    Conserved Domains (1) summary
    cl14813
    Location:14124
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
  10. XM_017013783.2XP_016869272.1  transcription initiation factor TFIID subunit 2 isoform X5

    Conserved Domains (2) summary
    pfam13646
    Location:441496
    HEAT_2; HEAT repeats
    cl14813
    Location:1330
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
  11. XM_017013780.1XP_016869269.1  transcription initiation factor TFIID subunit 2 isoform X4

    Conserved Domains (2) summary
    cd09839
    Location:2372
    M1_TAF2; TATA binding protein (TBP) associated factor 2
    pfam13646
    Location:483538
    HEAT_2; HEAT repeats
  12. XM_017013781.1XP_016869270.1  transcription initiation factor TFIID subunit 2 isoform X4

    Conserved Domains (2) summary
    cd09839
    Location:2372
    M1_TAF2; TATA binding protein (TBP) associated factor 2
    pfam13646
    Location:483538
    HEAT_2; HEAT repeats
  13. XM_017013782.1XP_016869271.1  transcription initiation factor TFIID subunit 2 isoform X4

    Conserved Domains (2) summary
    cd09839
    Location:2372
    M1_TAF2; TATA binding protein (TBP) associated factor 2
    pfam13646
    Location:483538
    HEAT_2; HEAT repeats
  14. XM_017013786.2XP_016869275.1  transcription initiation factor TFIID subunit 2 isoform X6

    UniProtKB/TrEMBL
    A0A024R9E6
    Conserved Domains (1) summary
    cd09839
    Location:2372
    M1_TAF2; TATA binding protein (TBP) associated factor 2
  15. XM_024447243.1XP_024303011.1  transcription initiation factor TFIID subunit 2 isoform X9

    Conserved Domains (1) summary
    cl14813
    Location:14124
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
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