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Ifitm1 interferon induced transmembrane protein 1 [ Mus musculus (house mouse) ]

Gene ID: 68713, updated on 12-May-2024

Summary

Official Symbol
Ifitm1provided by MGI
Official Full Name
interferon induced transmembrane protein 1provided by MGI
Primary source
MGI:MGI:1915963
See related
Ensembl:ENSMUSG00000025491 AllianceGenome:MGI:1915963
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mil2; Mil-2; DSPA2a; 1110036C17Rik
Summary
Involved in response to virus. Acts upstream of or within defense response to virus; negative regulation of viral entry into host cell; and somitogenesis. Predicted to be located in early endosome and lysosomal membrane. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in adenosquamous gallbladder carcinoma and gallbladder adenocarcinoma. Orthologous to human IFITM1 (interferon induced transmembrane protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 198.5), subcutaneous fat pad adult (RPKM 122.3) and 15 other tissues See more
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Genomic context

See Ifitm1 in Genome Data Viewer
Location:
7 F5; 7 86.2 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140547342..140549740)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (140967429..140969827)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene interferon induced transmembrane protein 5 Neighboring gene STARR-seq mESC enhancer starr_20461 Neighboring gene interferon induced transmembrane protein 2 Neighboring gene STARR-seq mESC enhancer starr_20462 Neighboring gene predicted gene 7514 Neighboring gene predicted gene, 33504

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (3)  1 citation

General gene information

Markers

Clone Names

  • MGC107121

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of viral entry into host cell IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of viral entry into host cell IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of viral entry into host cell IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of viral entry into host cell ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of viral genome replication IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ossification IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to interferon-alpha IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to interferon-alpha ISO
Inferred from Sequence Orthology
more info
 
involved_in response to interferon-beta IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to interferon-beta ISO
Inferred from Sequence Orthology
more info
 
involved_in response to type II interferon IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to type II interferon ISO
Inferred from Sequence Orthology
more info
 
involved_in response to virus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within somitogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in type I interferon-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in early endosome ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
interferon-induced transmembrane protein 1
Names
dispanin subfamily A member 2a
fragilis protein 2
fragilis2
ifitm-like protein 2
interferon induced transmembrane protein 2 like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001112715.1NP_001106186.1  interferon-induced transmembrane protein 1 isoform a

    See identical proteins and their annotated locations for NP_001106186.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AV136334, BC090972, BY198144
    Consensus CDS
    CCDS21995.1
    UniProtKB/Swiss-Prot
    Q8R2S7, Q9D103
    Related
    ENSMUSP00000026564.9, ENSMUST00000026564.9
    Conserved Domains (1) summary
    pfam04505
    Location:3399
    CD225; Interferon-induced transmembrane protein
  2. NM_001360727.1NP_001347656.1  interferon-induced transmembrane protein 1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 2. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AC162287
    Consensus CDS
    CCDS21995.1
    UniProtKB/Swiss-Prot
    Q8R2S7, Q9D103
    Related
    ENSMUSP00000101655.2, ENSMUST00000106040.8
    Conserved Domains (1) summary
    pfam04505
    Location:3399
    CD225; Interferon-induced transmembrane protein
  3. NM_001360728.1NP_001347657.1  interferon-induced transmembrane protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction in the 3' end compared to variant 2, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC162287
    Conserved Domains (1) summary
    pfam04505
    Location:3361
    CD225; Interferon-induced transmembrane protein
  4. NM_026820.3NP_081096.3  interferon-induced transmembrane protein 1 isoform a

    See identical proteins and their annotated locations for NP_081096.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AC162287, AV136334, BC090972, CR519995
    Consensus CDS
    CCDS21995.1
    UniProtKB/Swiss-Prot
    Q8R2S7, Q9D103
    Related
    ENSMUSP00000101657.3, ENSMUST00000106042.9
    Conserved Domains (1) summary
    pfam04505
    Location:3399
    CD225; Interferon-induced transmembrane protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    140547342..140549740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)