Ifitm1 interferon induced transmembrane protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ifitm1provided by MGI
Official Full Name: interferon induced transmembrane protein 1provided by MGI
Primary source: MGI:MGI:1915963
See related: Ensembl:ENSMUSG00000025491 AllianceGenome:MGI:1915963
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mil2; Mil-2; DSPA2a; 1110036C17Rik
Summary: Involved in response to virus. Acts upstream of or within defense response to virus; negative regulation of viral entry into host cell; and somitogenesis. Predicted to be located in early endosome and lysosomal membrane. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in adenosquamous gallbladder carcinoma and gallbladder adenocarcinoma. Orthologous to human IFITM1 (interferon induced transmembrane protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in ovary adult (RPKM 198.5), subcutaneous fat pad adult (RPKM 122.3) and 15 other tissues See more
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Genomic context

Location:: 7; 7 F5

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (140547342..140549740)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (140967429..140969827)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The double face of miR-320: cardiomyocytes-derived miR-320 deteriorated while fibroblasts-derived miR-320 protected against heart failure induced by transverse aortic constriction.
Title: The double face of miR-320: cardiomyocytes-derived miR-320 deteriorated while fibroblasts-derived miR-320 protected against heart failure induced by transverse aortic constriction.
Age-related onset of obesity corresponds with metabolic dysregulation and altered microglia morphology in mice deficient for Ifitm proteins.
Title: Age-related onset of obesity corresponds with metabolic dysregulation and altered microglia morphology in mice deficient for Ifitm proteins.
the importance of the C-terminal region of IFITM1 in modulating the antiviral function through controlling protein subcellular localization.
Title: The C-terminal sequence of IFITM1 regulates its anti-HIV-1 activity.
Palmitoylation of IFITM1 regulates protein stability by preventing proteasomal degradation, and modification of the nonconserved cysteine at the IFITM1 C terminus supports an intramembrane topology with implications for anti-influenza A virus activity.
Title: Palmitoylation on conserved and nonconserved cysteines of murine IFITM1 regulates its stability and anti-influenza A virus activity.
the fact that IFITM1 can function as a negative regulator of cell proliferation, and because the gene maps to chromosome band 11p15.5, previously associated with NSCLC, it is likely that IFITM1 in man has a key role in tumor formation
Title: In vivo functional requirement of the mouse Ifitm1 gene for germ cell development, interferon mediated immune response and somitogenesis.
Fragilis2 regulates epithelialization of the somites and paraxial mesoderm formation.
Title: Dissecting Wnt/beta-catenin signaling during gastrulation using RNA interference in mouse embryos.
The antiproliferative action of IFN-gamma requires the induction of IFITM1.
Title: IFITM1 plays an essential role in the antiproliferative action of interferon-gamma.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (3) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

Mil2-pending (e-PCR), detects polymorphism
- UniSTS:257229

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior/posterior pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within defense response to virus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral entry into host cell	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within negative regulation of viral entry into host cell	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of viral entry into host cell	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of viral entry into host cell	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral genome replication	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ossification	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in response to interferon-alpha	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in response to interferon-alpha	ISO Inferred from Sequence Orthology more info
involved_in response to interferon-beta	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in response to interferon-beta	ISO Inferred from Sequence Orthology more info
involved_in response to type II interferon	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in response to type II interferon	ISO Inferred from Sequence Orthology more info
involved_in response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in type I interferon-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
located_in early endosome	ISO Inferred from Sequence Orthology more info	PubMed
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: interferon-induced transmembrane protein 1

Names: dispanin subfamily A member 2a; fragilis protein 2; fragilis2; ifitm-like protein 2; interferon induced transmembrane protein 2 like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001112715.1 → NP_001106186.1 interferon-induced transmembrane protein 1 isoform a

See identical proteins and their annotated locations for NP_001106186.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).

Source sequence(s)

AV136334, BC090972, BY198144

Consensus CDS

CCDS21995.1

UniProtKB/Swiss-Prot

Q8R2S7, Q9D103

Related

ENSMUSP00000026564.9, ENSMUST00000026564.9

Conserved Domains (1) summary

pfam04505
Location:33 → 99

CD225; Interferon-induced transmembrane protein
NM_001360727.1 → NP_001347656.1 interferon-induced transmembrane protein 1 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 2. Variants 1, 2, and 3 all encode the same isoform (a).

Source sequence(s)

AC162287

Consensus CDS

CCDS21995.1

UniProtKB/Swiss-Prot

Q8R2S7

Related

ENSMUSP00000101655.2, ENSMUST00000106040.8

Conserved Domains (1) summary

pfam04505
Location:33 → 99

CD225; Interferon-induced transmembrane protein
NM_001360728.1 → NP_001347657.1 interferon-induced transmembrane protein 1 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate splice junction in the 3' end compared to variant 2, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.

Source sequence(s)

AC162287

Conserved Domains (1) summary

pfam04505
Location:33 → 61

CD225; Interferon-induced transmembrane protein
NM_026820.3 → NP_081096.3 interferon-induced transmembrane protein 1 isoform a

See identical proteins and their annotated locations for NP_081096.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1, 2, and 3 all encode the same isoform (a).

Source sequence(s)

AC162287, AV136334, BC090972, CR519995

Consensus CDS

CCDS21995.1

UniProtKB/Swiss-Prot

Q8R2S7, Q9D103

Related

ENSMUSP00000101657.3, ENSMUST00000106042.9

Conserved Domains (1) summary

pfam04505
Location:33 → 99

CD225; Interferon-induced transmembrane protein