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TADA2A transcriptional adaptor 2A [ Homo sapiens (human) ]

Gene ID: 6871, updated on 19-Sep-2024

Summary

Official Symbol
TADA2Aprovided by HGNC
Official Full Name
transcriptional adaptor 2Aprovided by HGNC
Primary source
HGNC:HGNC:11531
See related
Ensembl:ENSG00000276234 MIM:602276; AllianceGenome:HGNC:11531
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADA2; ADA2A; KL04P; hADA2; TADA2L
Summary
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Oct 2009]
Annotation information
Note: ADA2 is an official symbol GeneID: 51816 and an alias on GeneID: 687. GeneID: 6871 is frequently referred to as ADA2 in the literature, and publications belonging to GeneID:51816 are sometimes mis-associated with GeneID: 6871 [06 Jul 2018]
Expression
Ubiquitous expression in testis (RPKM 5.3), brain (RPKM 4.5) and 25 other tissues See more
Orthologs
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Genomic context

See TADA2A in Genome Data Viewer
Location:
17q12
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (37406886..37479725)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (38397046..38466403)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (35766977..35839830)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene acetyl-CoA carboxylase alpha Neighboring gene small nucleolar RNA, H/ACA box 90 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35712269-35712768 Neighboring gene chromosome 17 open reading frame 78 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:35768105-35768789 Neighboring gene ribosomal protein L24 pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr17:35814497-35815074 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:35815591-35816092 Neighboring gene MPRA-validated peak2830 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35843239-35843740 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:35851097-35851882 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:35867118-35867618 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:35867619-35868119 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:35872759-35873272 Neighboring gene dual specificity phosphatase 14 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:35901785-35902984 Neighboring gene synergin gamma Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35949209-35949710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35949711-35950210

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ12705

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell division IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell division ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of embryonic development ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of tubulin deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of tubulin deacetylation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of ATAC complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of ATAC complex ISO
Inferred from Sequence Orthology
more info
 
part_of SAGA complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of SAGA complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of SAGA-type complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitotic spindle NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
transcriptional adapter 2-alpha
Names
ADA2-like protein
transcriptional adaptor 2 alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166105.3NP_001159577.2  transcriptional adapter 2-alpha isoform a

    See identical proteins and their annotated locations for NP_001159577.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode the same isoform (a).
    Source sequence(s)
    AC243654, AK225918, BC011753, DA244842
    Consensus CDS
    CCDS11319.1
    UniProtKB/TrEMBL
    A0A024R0U3, A0A024R0Y4
    Related
    ENSP00000481091.1, ENST00000615182.5
    Conserved Domains (1) summary
    COG5114
    Location:28440
    COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
  2. NM_001291918.2NP_001278847.1  transcriptional adapter 2-alpha isoform b

    See identical proteins and their annotated locations for NP_001278847.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and represents an alternate transcript termination and polyadenylation site compared to variant 1. This results in a shorter isoform (b) which has a distinct C-terminus compared to isoform a. Variants 2 and 4 both encode the same isoform (b).
    Source sequence(s)
    AC243654, BC001172, DA244842
    Consensus CDS
    CCDS45656.1
    UniProtKB/TrEMBL
    A0A087WWR4
    Related
    ENSP00000480446.1, ENST00000620367.4
    Conserved Domains (1) summary
    COG5114
    Location:28272
    COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
  3. NM_001488.5NP_001479.4  transcriptional adapter 2-alpha isoform a

    See identical proteins and their annotated locations for NP_001479.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the predominant transcript and encodes the longest isoform (a). Variants 1 and 3 both encode the same isoform (a).
    Source sequence(s)
    AC243654, AK022767, BC011753
    Consensus CDS
    CCDS11319.1
    UniProtKB/TrEMBL
    A0A024R0U3, A0A024R0Y4
    Related
    ENSP00000477709.1, ENST00000612272.4
    Conserved Domains (1) summary
    COG5114
    Location:28440
    COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
  4. NM_133439.4NP_597683.3  transcriptional adapter 2-alpha isoform b

    See identical proteins and their annotated locations for NP_597683.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents an alternate transcript termination and polyadenylation site compared to variant 1. This results in a shorter isoform (b) which has a distinct C-terminus compared to isoform a. Variants 2 and 4 both encode the same isoform (b).
    Source sequence(s)
    AC243654, AK022767, BC001172
    Consensus CDS
    CCDS45656.1
    UniProtKB/TrEMBL
    A0A087WWR4
    Conserved Domains (1) summary
    COG5114
    Location:28272
    COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    37406886..37479725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024982.1XP_016880471.1  transcriptional adapter 2-alpha isoform X3

    Conserved Domains (1) summary
    COG5114
    Location:28386
    COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
  2. XM_017024981.2XP_016880470.1  transcriptional adapter 2-alpha isoform X2

    Conserved Domains (1) summary
    COG5114
    Location:28420
    COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
  3. XM_047436612.1XP_047292568.1  transcriptional adapter 2-alpha isoform X3

    Conserved Domains (1) summary
    COG5114
    Location:28386
    COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
  4. XM_047436610.1XP_047292566.1  transcriptional adapter 2-alpha isoform X2

  5. XM_011525154.3XP_011523456.1  transcriptional adapter 2-alpha isoform X4

    See identical proteins and their annotated locations for XP_011523456.1

    Conserved Domains (1) summary
    COG5114
    Location:2377
    COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
  6. XM_047436613.1XP_047292569.1  transcriptional adapter 2-alpha isoform X5

    UniProtKB/TrEMBL
    B3KU13
  7. XM_047436609.1XP_047292565.1  transcriptional adapter 2-alpha isoform X1

    UniProtKB/TrEMBL
    A0A024R0U3, A0A024R0Y4
  8. XM_017024985.2XP_016880474.1  transcriptional adapter 2-alpha isoform X5

    UniProtKB/TrEMBL
    B3KU13
    Conserved Domains (2) summary
    COG5114
    Location:3339
    COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
    pfam04433
    Location:273339
    SWIRM; SWIRM domain
  9. XM_017024983.2XP_016880472.1  transcriptional adapter 2-alpha isoform X5

    UniProtKB/TrEMBL
    B3KU13
    Conserved Domains (2) summary
    COG5114
    Location:3339
    COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
    pfam04433
    Location:273339
    SWIRM; SWIRM domain

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    1646042..1718895
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329314.1XP_054185289.1  transcriptional adapter 2-alpha isoform X3

  2. XM_054329313.1XP_054185288.1  transcriptional adapter 2-alpha isoform X2

  3. XM_054329317.1XP_054185292.1  transcriptional adapter 2-alpha isoform X5

    UniProtKB/TrEMBL
    B3KU13
  4. XM_054329315.1XP_054185290.1  transcriptional adapter 2-alpha isoform X5

    UniProtKB/TrEMBL
    B3KU13
  5. XM_054329316.1XP_054185291.1  transcriptional adapter 2-alpha isoform X5

    UniProtKB/TrEMBL
    B3KU13

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    38397046..38466403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054317020.1XP_054172995.1  transcriptional adapter 2-alpha isoform X3

  2. XM_054317018.1XP_054172993.1  transcriptional adapter 2-alpha isoform X2

  3. XM_054317016.1XP_054172991.1  transcriptional adapter 2-alpha isoform X1

    UniProtKB/Swiss-Prot
    A8MVD0, B3KMU9, O75478, Q9BVJ0, Q9UCW2, Q9UP49
    UniProtKB/TrEMBL
    A0A0S2Z4G1
  4. XM_054317019.1XP_054172994.1  transcriptional adapter 2-alpha isoform X3

  5. XM_054317017.1XP_054172992.1  transcriptional adapter 2-alpha isoform X2

  6. XM_054317021.1XP_054172996.1  transcriptional adapter 2-alpha isoform X4

  7. XM_054317024.1XP_054172999.1  transcriptional adapter 2-alpha isoform X5

    UniProtKB/TrEMBL
    B3KU13
  8. XM_054317022.1XP_054172997.1  transcriptional adapter 2-alpha isoform X5

    UniProtKB/TrEMBL
    B3KU13
  9. XM_054317023.1XP_054172998.1  transcriptional adapter 2-alpha isoform X5

    UniProtKB/TrEMBL
    B3KU13