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TADA2A transcriptional adaptor 2A [ Homo sapiens (human) ]

Gene ID: 6871, updated on 9-Dec-2018

Summary

Official Symbol
TADA2Aprovided by HGNC
Official Full Name
transcriptional adaptor 2Aprovided by HGNC
Primary source
HGNC:HGNC:11531
See related
Ensembl:ENSG00000276234 MIM:602276
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADA2; ADA2A; KL04P; hADA2; TADA2L
Summary
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Oct 2009]
Annotation information
Note: ADA2 is an official symbol GeneID: 51816 and an alias on GeneID: 687. GeneID: 6871 is frequently referred to as ADA2 in the literature, and publications belonging to GeneID:51816 are sometimes mis-associated with GeneID: 6871 [06 Jul 2018]
Expression
Ubiquitous expression in testis (RPKM 5.3), brain (RPKM 4.5) and 25 other tissues See more
Orthologs

Genomic context

See TADA2A in Genome Data Viewer
Location:
17q12
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (37406877..37479725)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (35766977..35839830)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene acetyl-CoA carboxylase alpha Neighboring gene small nucleolar RNA, H/ACA box 90 Neighboring gene chromosome 17 open reading frame 78 Neighboring gene ribosomal protein L24 pseudogene Neighboring gene dual specificity phosphatase 14 Neighboring gene synergin gamma

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
NHGRI GWA Catalog

Pathways from BioSystems

  • Chromatin modifying enzymes, organism-specific biosystem (from REACTOME)
    Chromatin modifying enzymes, organism-specific biosystemEukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect i...
  • Chromatin organization, organism-specific biosystem (from REACTOME)
    Chromatin organization, organism-specific biosystemChromatin organization refers to the composition and conformation of complexes between DNA, protein and RNA. It is determined by processes that result in the specification, formation or maintenance o...
  • HATs acetylate histones, organism-specific biosystem (from REACTOME)
    HATs acetylate histones, organism-specific biosystemHistone acetyltransferases (HATs) involved in histone modifications are referred to as A-type or nuclear HATs. They can be grouped into at least four families based on sequence conservation within th...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12705

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to histone acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone H3 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of histone acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of nucleic acid-templated transcription IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
PCAF complex IDA
Inferred from Direct Assay
more info
PubMed 
SAGA-type complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromosome IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transcriptional adapter 2-alpha
Names
ADA2-like protein
transcriptional adaptor 2 alpha

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166105.3NP_001159577.2  transcriptional adapter 2-alpha isoform a

    See identical proteins and their annotated locations for NP_001159577.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode the same isoform (a).
    Source sequence(s)
    AC243654, AK225918, BC011753, DA244842
    Consensus CDS
    CCDS11319.1
    UniProtKB/Swiss-Prot
    O75478
    UniProtKB/TrEMBL
    A0A024R0Y4
    Related
    ENSP00000481091.1, ENST00000615182.4
    Conserved Domains (1) summary
    COG5114
    Location:28440
    COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
  2. NM_001291918.1NP_001278847.1  transcriptional adapter 2-alpha isoform b

    See identical proteins and their annotated locations for NP_001278847.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and represents an alternate transcript termination and polyadenylation site compared to variant 1. This results in a shorter isoform (b) which has a distinct C-terminus compared to isoform a. Variants 2 and 4 both encode the same isoform (b).
    Source sequence(s)
    AC243654, BC001172, DA244842
    Consensus CDS
    CCDS45656.1
    UniProtKB/Swiss-Prot
    O75478
    UniProtKB/TrEMBL
    A0A087WWR4
    Related
    ENSP00000480446.1, ENST00000620367.4
    Conserved Domains (1) summary
    COG5114
    Location:28272
    COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
  3. NM_001488.4NP_001479.4  transcriptional adapter 2-alpha isoform a

    See identical proteins and their annotated locations for NP_001479.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the predominant transcript and encodes the longest isoform (a). Variants 1 and 3 both encode the same isoform (a).
    Source sequence(s)
    AC243654, AK022767, BC011753
    Consensus CDS
    CCDS11319.1
    UniProtKB/Swiss-Prot
    O75478
    UniProtKB/TrEMBL
    A0A024R0Y4
    Related
    ENSP00000477709.1, ENST00000612272.4
    Conserved Domains (1) summary
    COG5114
    Location:28440
    COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
  4. NM_133439.3NP_597683.3  transcriptional adapter 2-alpha isoform b

    See identical proteins and their annotated locations for NP_597683.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents an alternate transcript termination and polyadenylation site compared to variant 1. This results in a shorter isoform (b) which has a distinct C-terminus compared to isoform a. Variants 2 and 4 both encode the same isoform (b).
    Source sequence(s)
    AC243654, AK022767, BC001172
    Consensus CDS
    CCDS45656.1
    UniProtKB/Swiss-Prot
    O75478
    UniProtKB/TrEMBL
    A0A087WWR4
    Conserved Domains (1) summary
    COG5114
    Location:28272
    COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    37406877..37479725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024984.1XP_016880473.1  transcriptional adapter 2-alpha isoform X4

    UniProtKB/TrEMBL
    B3KU13
    Conserved Domains (2) summary
    COG5114
    Location:3339
    COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
    pfam04433
    Location:273339
    SWIRM; SWIRM domain
  2. XM_017024985.1XP_016880474.1  transcriptional adapter 2-alpha isoform X4

    UniProtKB/TrEMBL
    B3KU13
    Conserved Domains (2) summary
    COG5114
    Location:3339
    COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
    pfam04433
    Location:273339
    SWIRM; SWIRM domain
  3. XM_011525153.2XP_011523455.1  transcriptional adapter 2-alpha isoform X3

    See identical proteins and their annotated locations for XP_011523455.1

    Conserved Domains (1) summary
    COG5114
    Location:2377
    COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
  4. XM_011525155.2XP_011523457.1  transcriptional adapter 2-alpha isoform X4

    See identical proteins and their annotated locations for XP_011523457.1

    UniProtKB/TrEMBL
    B3KU13
    Conserved Domains (2) summary
    COG5114
    Location:3339
    COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
    pfam04433
    Location:273339
    SWIRM; SWIRM domain
  5. XM_006722044.3XP_006722107.1  transcriptional adapter 2-alpha isoform X4

    See identical proteins and their annotated locations for XP_006722107.1

    UniProtKB/TrEMBL
    B3KU13
    Conserved Domains (2) summary
    COG5114
    Location:3339
    COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
    pfam04433
    Location:273339
    SWIRM; SWIRM domain
  6. XM_017024983.1XP_016880472.1  transcriptional adapter 2-alpha isoform X4

    UniProtKB/TrEMBL
    B3KU13
    Conserved Domains (2) summary
    COG5114
    Location:3339
    COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
    pfam04433
    Location:273339
    SWIRM; SWIRM domain
  7. XM_017024986.1XP_016880475.1  transcriptional adapter 2-alpha isoform X5

    Conserved Domains (2) summary
    COG5114
    Location:2236
    COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
    pfam04433
    Location:170236
    SWIRM; SWIRM domain
  8. XM_017024982.1XP_016880471.1  transcriptional adapter 2-alpha isoform X2

    Conserved Domains (4) summary
    COG5114
    Location:28386
    COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
    cd00167
    Location:74118
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    cd02335
    Location:1564
    ZZ_ADA2; Zinc finger, ZZ type. Zinc finger present in ADA2, a putative transcriptional adaptor, and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam04433
    Location:320386
    SWIRM; SWIRM domain
  9. XM_017024981.1XP_016880470.1  transcriptional adapter 2-alpha isoform X1

    Conserved Domains (4) summary
    COG5114
    Location:28420
    COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
    cd00167
    Location:5498
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam04433
    Location:354420
    SWIRM; SWIRM domain
    cl00295
    Location:1544
    ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
  10. XM_011525154.2XP_011523456.1  transcriptional adapter 2-alpha isoform X3

    See identical proteins and their annotated locations for XP_011523456.1

    Conserved Domains (1) summary
    COG5114
    Location:2377
    COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    1646042..1716291
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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