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TACR3 tachykinin receptor 3 [ Homo sapiens (human) ]

Gene ID: 6870, updated on 7-Sep-2023

Summary

Official Symbol
TACR3provided by HGNC
Official Full Name
tachykinin receptor 3provided by HGNC
Primary source
HGNC:HGNC:11528
See related
Ensembl:ENSG00000169836 MIM:162332; AllianceGenome:HGNC:11528
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NK3; NKR; HH11; NK3R; NK-3R; TAC3R; TAC3RL
Summary
This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See TACR3 in Genome Data Viewer
Location:
4q24
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (103586031..103719985, complement)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (106897954..107031922, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (104507188..104641142, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene NANOG hESC enhancer GRCh37_chr4:104345927-104346428 Neighboring gene long intergenic non-protein coding RNA 2428 Neighboring gene DEAD-box helicase 3 pseudogene 3 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:104867518-104868402 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:104868403-104869285 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:104869315-104869938 Neighboring gene RNA, U6 small nuclear 635, pseudogene Neighboring gene Sharpr-MPRA regulatory region 10992 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:105169645-105170166 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:105170167-105170687 Neighboring gene uncharacterized LOC105377350

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC148060, MGC148061

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tachykinin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in dendrite membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in sperm midpiece IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in sperm midpiece IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
neuromedin-K receptor
Names
NK-3 receptor
NK3 receptor
neurokinin B receptor
neurokinin beta receptor
NP_001050.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023344.1 RefSeqGene

    Range
    5001..135349
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001059.3NP_001050.1  neuromedin-K receptor

    See identical proteins and their annotated locations for NP_001050.1

    Status: REVIEWED

    Source sequence(s)
    AC004065, AC105460, M89473
    Consensus CDS
    CCDS3664.1
    UniProtKB/Swiss-Prot
    P29371, Q0P510
    UniProtKB/TrEMBL
    A0A1B0RPQ1
    Related
    ENSP00000303325.2, ENST00000304883.3
    Conserved Domains (1) summary
    cd16003
    Location:86367
    7tmA_NKR_NK3R; neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    103586031..103719985 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    106897954..107031922 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)