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TACR3 tachykinin receptor 3 [ Homo sapiens (human) ]

Gene ID: 6870, updated on 7-Sep-2023

Summary

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Official Symbol
TACR3provided by HGNC
Official Full Name
tachykinin receptor 3provided by HGNC
Primary source
HGNC:HGNC:11528
See related
Ensembl:ENSG00000169836 MIM:162332; AllianceGenome:HGNC:11528
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NK3; NKR; HH11; NK3R; NK-3R; TAC3R; TAC3RL
Summary
This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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See TACR3 in Genome Data Viewer
Location:
4q24
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (103586031..103719985, complement)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (106897954..107031922, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (104507188..104641142, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene NANOG hESC enhancer GRCh37_chr4:104345927-104346428 Neighboring gene long intergenic non-protein coding RNA 2428 Neighboring gene DEAD-box helicase 3 pseudogene 3 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:104867518-104868402 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:104868403-104869285 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:104869315-104869938 Neighboring gene RNA, U6 small nuclear 635, pseudogene Neighboring gene Sharpr-MPRA regulatory region 10992 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:105169645-105170166 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:105170167-105170687 Neighboring gene uncharacterized LOC105377350

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel stopgain mutation c.G992A (p.W331X) in TACR3 gene was identified in nonobstructive azoospermia by targeted next-generation sequencing. Geng D, et al. J Clin Lab Anal, 2019 Mar. PMID 30390321, Free PMC Article
  2. Role of Neurokinin 3 Receptor Signaling in Oral Squamous Cell Carcinoma. Obata K, et al. Anticancer Res, 2017 Nov. PMID 29061792
  3. Association of genetic variation in the tachykinin receptor 3 locus with hot flashes and night sweats in the Women's Health Initiative Study. Crandall CJ, et al. Menopause, 2017 Mar. PMID 28231077, Free PMC Article
  4. Tachykinin Receptor 3 Distribution in Human Oral Squamous Cell Carcinoma. Obata K, et al. Anticancer Res, 2016 Dec. PMID 27919954
  5. TACR3 mutations disrupt NK3R function through distinct mechanisms in GnRH-deficient patients. Noel SD, et al. FASEB J, 2014 Apr. PMID 24376026, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The overexpression of neurokinin B-neurokinin 3 receptor system exerts direct effects on the ovary under PCOS-like conditions to interfere with mitochondrial function.
    Title: The overexpression of neurokinin B-neurokinin 3 receptor system exerts direct effects on the ovary under PCOS-like conditions to interfere with mitochondrial function.
  2. Neurokinin receptors in drug and alcohol addiction.
    Title: Neurokinin receptors in drug and alcohol addiction.
  3. Identified a newly discovered stopgain mutation in tachykinin receptor 3 (TACR3) in nonobstructive azoospermia paitents.
    Title: A novel stopgain mutation c.G992A (p.W331X) in TACR3 gene was identified in nonobstructive azoospermia by targeted next-generation sequencing.
  4. Three Single-nucleotide polymorphisms (on chromosomes 3 and 11) were associated with vasomotor menopause symptoms in the African American group. However, 14 Single-nucleotide polymorphisms, all located on chromosome 4 in the tachykinin receptor 3 (TACR3) locus, had similar effect sizes across studies/participants' ancestry. Genetic variation in TACR3 may contribute to the risk of vasomotor menopause symptoms.
    Title: Association of genetic variation in the tachykinin receptor 3 locus with hot flashes and night sweats in the Women's Health Initiative Study.
  5. observations of interspecies variation in the neurokinin 3 receptor brain localization with more extensive distribution in guinea pig than in primate brain; in the human brain, specific binding to the neurokinin 3 receptor was highest in the amygdala and in the hypothalamus and very low in other regions examined
    Title: Neurokinin-3 Receptor Binding in Guinea Pig, Monkey, and Human Brain: In Vitro and in Vivo Imaging Using the Novel Radioligand, [18F]Lu AF10628.
  6. High NK-3R expression is associated with Oral Squamous Cell Carcinoma.
    Title: Role of Neurokinin 3 Receptor Signaling in Oral Squamous Cell Carcinoma.
  7. reduced to an almost undetectable level in polycystic ovary syndrome granulosa cells
    Title: Neurokinin B Exerts Direct Effects on the Ovary to Stimulate Estradiol Production.
  8. Neuropeptide derivatives to regulate the reproductive axis: Kisspeptin receptor (KISS1R) ligands and neurokinin-3 receptor (NK3R) ligands.
    Title: Neuropeptide derivatives to regulate the reproductive axis: Kisspeptin receptor (KISS1R) ligands and neurokinin-3 receptor (NK3R) ligands.
  9. results suggest that peripheral sensory nerve-derived TAC3 may affect gingival oral squamous cell carcinoma cells through TACR3 in the bone matrix
    Title: Tachykinin Receptor 3 Distribution in Human Oral Squamous Cell Carcinoma.
  10. mutations in TAC and TACR3 are not a common cause for ICPP.
    Title: Mutational analysis of TAC and TACR3 in idiopathic central precocious puberty.
Submit: New GeneRIF Correction See all GeneRIFs (34)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC148060, MGC148061

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tachykinin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of flagellated sperm motility IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in positive regulation of flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of heart rate IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of uterine smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of dopamine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of feeding behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in response to cocaine IEA
Inferred from Electronic Annotation
more info
  
involved_in response to estradiol IEA
Inferred from Electronic Annotation
more info
  
involved_in tachykinin receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in dendrite membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
is_active_in sperm midpiece IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in sperm midpiece IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
neuromedin-K receptor
Names
NK-3 receptor
NK3 receptor
neurokinin B receptor
neurokinin beta receptor
NP_001050.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023344.1 RefSeqGene

    Range
    5001..135349
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001059.3 → NP_001050.1  neuromedin-K receptor

    See identical proteins and their annotated locations for NP_001050.1

    Status: REVIEWED

    Source sequence(s)
    AC004065, AC105460, M89473
    Consensus CDS
    CCDS3664.1
    UniProtKB/Swiss-Prot
    P29371, Q0P510
    UniProtKB/TrEMBL
    A0A1B0RPQ1
    Related
    ENSP00000303325.2, ENST00000304883.3
    Conserved Domains (1) summary
    cd16003
    Location:86 → 367
    7tmA_NKR_NK3R; neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    103586031..103719985 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    106897954..107031922 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P29371.1 GenPept UniProtKB/Swiss-Prot:P29371

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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