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TACR3 tachykinin receptor 3 [ Homo sapiens (human) ]

Gene ID: 6870, updated on 1-Jun-2020

Summary

Official Symbol
TACR3provided by HGNC
Official Full Name
tachykinin receptor 3provided by HGNC
Primary source
HGNC:HGNC:11528
See related
Ensembl:ENSG00000169836 MIM:162332
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NK3; NKR; HH11; NK3R; NK-3R; TAC3R; TAC3RL
Summary
This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See TACR3 in Genome Data Viewer
Location:
4q24
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (103586031..103719985, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (104510625..104640973, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2428 Neighboring gene DEAD-box helicase 3 pseudogene 3 Neighboring gene RNA, U6 small nuclear 635, pseudogene Neighboring gene long intergenic non-protein coding RNA 2503

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC148060, MGC148061

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
tachykinin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
aging IEA
Inferred from Electronic Annotation
more info
 
hyperosmotic salinity response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
positive regulation of flagellated sperm motility IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of heart rate IEA
Inferred from Electronic Annotation
more info
 
positive regulation of uterine smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
regulation of dopamine metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of feeding behavior IEA
Inferred from Electronic Annotation
more info
 
response to cocaine IEA
Inferred from Electronic Annotation
more info
 
response to estradiol IEA
Inferred from Electronic Annotation
more info
 
response to morphine IEA
Inferred from Electronic Annotation
more info
 
tachykinin receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
dendrite membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
neuronal cell body membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
sperm midpiece IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sperm midpiece IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
neuromedin-K receptor
Names
NK-3 receptor
NK3 receptor
neurokinin B receptor
neurokinin beta receptor
NP_001050.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023344.1 RefSeqGene

    Range
    5001..135349
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001059.3NP_001050.1  neuromedin-K receptor

    See identical proteins and their annotated locations for NP_001050.1

    Status: REVIEWED

    Source sequence(s)
    AC004065, AC105460, M89473
    Consensus CDS
    CCDS3664.1
    UniProtKB/Swiss-Prot
    P29371
    Related
    ENSP00000303325.2, ENST00000304883.3
    Conserved Domains (1) summary
    cd16003
    Location:86367
    7tmA_NKR_NK3R; neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    103586031..103719985 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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